| 异谷树碱的抗炎作用 |
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| 引用本文： | 林志共,蔡文,唐希灿.异谷树碱的抗炎作用[J].中国药理学通报,1987(4). |
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| 作者姓名： | 林志共 蔡文 唐希灿 |
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| 作者单位： | 中国药品生物制品检定所
(林志共)，浙江嘉兴卫生学校
(蔡文)，中国科学院上海药物研究所(唐希灿) |
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| 摘 要： | 异谷树碱400mg/kg灌胃给药,可显著抑制毛细血管通透性增加,二甲苯、角叉菜胶、鸡蛋清和甲醛等致炎剂产生的水肿,白细胞游走和棉球肉芽肿增生。异谷树碱对酵母发热大鼠有明显解热作用。结果表明,异谷树碱具有抗炎效应。
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| 关 键 词： | 异谷树碱 阿司匹林 氢化可的松 抗炎 解热 |
ANTI-INFLAMMATORY EFFECT OF d-ISOCHONDRODENDRINE |
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| Lin Zhigong,Cai Wen & Tang Xican.ANTI-INFLAMMATORY EFFECT OF d-ISOCHONDRODENDRINE[J].Chinese Pharmacological Bulletin,1987(4). |
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| Authors: | Lin Zhigong Cai Wen & Tang Xican |
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| Abstract: | d-Isochondordendrine isolated from Cyclea barbate Miers, 400-800 rng/kg ig inhibited the increased vascular permeability induced by ip 0.7% acetic acid in mice or histamine ic 0.05ug/0.05ml in rats. It markedly inhibited the swelling of mouse ear induced by xylene and the edema produced by injection of 1 % carrageenin , fresh egg white or 2.5% formaldehyde 0.lml beneath the plantar surface of hind paw in intact or adrenalectomized rats. It was effective in the cotton-pellet grahuloma inhibition test in rats after daily medica- tion for 6 d. d-lsochondrodendrine could significantly rnduce the leukocyte removal caused by 1 % carrageenin and the fever induced by sc 7% yeast suspension 3 ml/kg in rats |
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| Keywords: | d-Isochondrodendrine Aspirin Hhydrocorti sone Anti- inflammatory Antipyretir |
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