一氧化氮治疗先天性心脏病体外循环术后肺动脉高压的临床评价

目的评估吸入一氧化氮治疗先天性心脏病体外循环术后肺动脉高压的效果。方法 20例先天性心脏病术后有肺动脉高压或肺高压危象临床表现患者,用吸入一氧化氮法治疗,比较治疗前后中心静脉压和血氧分压的变化。结果 20例患者在其他治疗不变的前提下,经过吸入一氧化氮治疗后,中心静脉压比治疗前明显下降,血氧分压比治疗前明显增高,差异有统计学意义[(58.2±16.8)kPavs.(46.0±13.9)kPa,P0.05;(13.2±4.70)mmHgvs.(24.3±4.4)mmHg,P0.05](1mmHg=0.133kPa)。结论吸入一氧化氮治疗先天性心脏病体外循环术后肺动脉高压有良好的临床效果。

Clinical evaluation of inhaling nitrogen monoxidum pulmonary hypertension after by-pass congenital heart diseases

Objectives To evaluate the effect of inhaling nitrogen monoxidum （NO）on treating pulmonary hypertension after by-pass of congenital heart diseases. Methods All 20 patients enrolled who had clinical presentations of the pulmonary hypertension or puhnonary hypertension crisis after by-pass of congenital heart diseases, and were treated with inhaling NO. Central venous pressure （CVP） and partial pressure of oxygen（PaO2） were compared before and after treatment. Results After treated with inhaling NO, CVP of patients signifisantly decresed and PaO2 siginificantly increased [ （58.2 ±16.8）kPa vs. （46.0±13.9）kPa, P〈0.05 ; （ 13.2±4.70）mm Hg vs. （24.3±4.4）mm Hg, P〈0.05 ]. Conclusions diseases.