全文获取类型
收费全文 | 6816篇 |
免费 | 366篇 |
国内免费 | 271篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 97篇 |
妇产科学 | 188篇 |
基础医学 | 594篇 |
口腔科学 | 229篇 |
临床医学 | 714篇 |
内科学 | 1915篇 |
皮肤病学 | 83篇 |
神经病学 | 516篇 |
特种医学 | 76篇 |
外国民族医学 | 11篇 |
外科学 | 729篇 |
综合类 | 616篇 |
现状与发展 | 5篇 |
预防医学 | 577篇 |
眼科学 | 81篇 |
药学 | 434篇 |
3篇 | |
中国医学 | 145篇 |
肿瘤学 | 417篇 |
出版年
2024年 | 51篇 |
2023年 | 420篇 |
2022年 | 603篇 |
2021年 | 1296篇 |
2020年 | 716篇 |
2019年 | 433篇 |
2018年 | 311篇 |
2017年 | 300篇 |
2016年 | 265篇 |
2015年 | 287篇 |
2014年 | 492篇 |
2013年 | 525篇 |
2012年 | 206篇 |
2011年 | 246篇 |
2010年 | 164篇 |
2009年 | 163篇 |
2008年 | 160篇 |
2007年 | 129篇 |
2006年 | 104篇 |
2005年 | 91篇 |
2004年 | 85篇 |
2003年 | 63篇 |
2002年 | 63篇 |
2001年 | 59篇 |
2000年 | 32篇 |
1999年 | 29篇 |
1998年 | 34篇 |
1997年 | 38篇 |
1996年 | 16篇 |
1995年 | 19篇 |
1994年 | 17篇 |
1993年 | 14篇 |
1992年 | 9篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 3篇 |
排序方式: 共有7453条查询结果,搜索用时 15 毫秒
1.
This meta-analysis was designed to assess the effectiveness and safety of extracorporeal shock wave therapy (ESWT) for patients with low back pain (LBP). Pubmed, Embase, Cochrane's library, PEDro (Physiotherapy Evidence Database), China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched until December 2019 to identify studies assessing the effectiveness and safety of EPSW for LBP. The prime outcome is pain intensity measured by Visual Analog Scale (VAS) or numeric rating scale (NRS). Other outcomes included functional status, quality of life, psychological outcomes measured by Oswestry Disability Index (ODI), as well as the adverse events. Mean differences (MD) were calculated for continuous outcomes, while odd ratios (OR) were calculated for binary outcomes. Revman 5.3 software was used for statistical analysis. Five randomized controlled trials (RCTs) were finally included in this meta-analysis. The pooled mean difference in post-treatment pain scores was −2.37 (P <0.0001), indicating that post-treatment pain scores was significantly higher by 2.37 in control group than in ESWT group. At a mean follow-up time of 4–6 weeks, the pooled mean difference in ODI scores was −14.10 (P <0.00001), indicating that the pooled mean difference of post-treatment ODI scores was 14.10 higher in control group than in ESWT group. The use of ESWT is effective in alleviating pain and improving the general functional state for patients with LBP. However, more evidence was needed to verify its safety. 相似文献
2.
3.
4.
Peng Li Sha-Sha Tao Meng-Qin Zhao Jun Li Xiu Wang Hai-Feng Pan 《Immunological investigations》2015,44(7):603-615
Objective: Association of matrix metalloproteinases (MMPs) gene polymorphisms with rheumatoid arthritis is controversial. We conduct a meta-analysis to clarify this dispute.Methods: We systematically searched the electronic PUBMED, EMBASE and CNKI databases for research articles about MMPs (MMP-1, MMP-2, MMP-3, MMP-9) gene polymorphisms and rheumatoid arthritis (RA) up to January 2015. According to the heterogeneity, fixed-effects or random-effects models were used to calculate crude odds ratios (ORs) and 95% confidence intervals (95% CIs).Results: A total of 11 articles involving 2143 cases and 2049 controls were included in this meta-analysis. Overall, no significant associations were observed between MMP-1-1607 1G/2G polymorphism and RA. Stratification by ethnicity, no significant associations were observed in Caucasian populations. Similarly, no significant associations were observed between MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms and RA in overall and Caucasian populations, respectively. However, a weak association was found between MMP-2-1306 C/T polymorphism and RA (C vs. T, OR?=?0.813, 95%CI?=?0.694–0.953, p?=?0.010) in overall populations.Conclusions: The present meta-analysis suggests that MMP-1-1607 1G/2G, MMP-3-1171 5A/6A, MMP-9-1562 C/T polymorphisms are not associated with the susceptibility of RA, but MMP-2 -1306 C/T is weakly associated with susceptibility to RA. Further studies with more sample size are needed for definitive conclusions. 相似文献
5.
目的:采用网状Meta分析方法,将普萘洛尔联合其他治疗与各对照治疗措施进行对比。方法:以“普萘洛尔”,“血管瘤”为关键词检索CNKI、VIP、万方数据;以“propranolol”“hemangioma”为关键词检索Cochrane Library、Embase、pubmed。检索期限为建库至2019年6月1日。采用STATA14.0软件Network程序包进行数据分析。结果:共纳入18篇文献,涉及8项治疗措施,共纳入1469例血管瘤患者。网状Meta分析结果显示:4种联合治疗方式与单纯口服普萘洛尔相比疗效均优于单纯口服普萘洛尔治疗。普萘洛尔联合注射平阳霉素、普萘洛尔联合外用噻吗洛尔、普萘洛尔联合敷贴器的有效率均优于对应的注射平阳霉素、外用噻吗洛尔及敷贴器。各治疗措施的有效性排序为:普萘洛尔联合敷贴器>普萘洛尔联合外用噻吗洛尔>普萘洛尔联合口服糖皮质激素>普萘洛尔联合注射平阳霉素>敷贴器照射>外用噻吗洛尔>口服普萘洛尔>注射平阳霉素。结论:对于婴幼儿血管瘤的治疗,普萘洛尔联合治疗措施疗效均优于单纯的口服普萘洛尔治疗,其中普萘洛尔联合敷贴器的疗效最佳。 相似文献
6.
7.
文题释义:肱骨近端骨折:肱骨近端包括肱骨头及大结节、小结节,中老年人骨质疏松及低能量损伤可导致肱骨近端骨折。
同种异体腓骨:取自于人体异体,经过加工处理,去除其免疫原性,保留其骨性结构,可用于移植修复骨缺损,起到支撑作用。
背景:肱骨近端骨折是临床常见骨折,但对肱骨近端内侧柱缺乏支撑的骨折目前仍是治疗难点,并发症常见,失败率较高。
目的:比较解剖锁定钢板联合同种异体腓骨与单纯解剖锁定钢板治疗肱骨近端骨折的疗效。
方法:使用计算机检索PubMed、Embase、Cochrane Library、Google Scholar、中国知网、万方、维普数据库,检索时间均从建库到2020年2月。检索国内外关于对比研究解剖锁定钢板联合同种异体腓骨与单纯解剖锁定钢板治疗肱骨近端骨折疗效的文献。2名研究员根据纳入和排除标准分别独立筛选文献,提取数据,评估文献中的偏倚风险。纳入12篇相关文献使用RevMan 5.2软件将以下指标进行Meta分析,包括影像学数据、功能评分和并发症。结果与结论:①通过文献检索、根据纳入和排除标准,12篇文献纳入研究,其中11篇为回顾性队列研究,1篇为随机对照研究;纳入研究文献质量高,但GRADE证据质量级别较低。②共纳入958例患者,其中解剖锁定钢板联合同种异体腓骨组411例,单纯解剖锁定钢板组547例;③Meta分析结果显示,解剖锁定钢板联合同种异体腓骨组术后1年肱骨头高度差值(MD=-2.40,95%CI:-2.49至-2.31)、颈干角差值(MD= -6.14,95%CI:-6.62至-5.67)、目测类比评分(MD=-0.22,95%CI:-0.35至-0.08)、肩关节功能评分(MD=4.12,95%CI:2.18-6.06),上肢伤残评分(MD=-10.32,95%CI:-13.44至-7.19)、术后2年的目测类比评分(MD=-0.37,95%CI:-0.55至-0.19)、肩关节功能评分(MD=5.07,95%CI:2.86-7.27)、总体并发症(OR=0.31,95%CI:0.20-0.48)及肱骨头螺钉切出(OR=0.25,95%CI:0.11-0.55)均明显优于单纯解剖锁定钢板组(P < 0.05),肱骨头坏死(OR=0.94,95%CI:0.47-1.88),两组间差异无显著性意义(P > 0.05);④因此,较弱的证据提示,肱骨近端解剖锁定钢板联合同种异体腓骨治疗肱骨近端骨折的短期疗效优于解剖锁定钢板,可减少并发症的发生,促进功能恢复。ORCID: 0000-0002-8486-3932(阳运康)
中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程 相似文献
8.
《The Journal of arthroplasty》2022,37(2):390-397
BackgroundThe number of total hip arthroplasties performed per year is increasing for reasons not fully explained by a growing and aging population. The purpose of this study was to determine the role of patient functional status as an indication for surgery and determine if patients are undergoing surgery at a better functional status than in the past.MethodsA systematic review and meta-analysis of the MEDLINE, EMBASE, and Cochrane databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Functional status was assessed using the 36-Item Short-Form Health Survey’s Physical Component Summary score. Only primary procedures were included; revisions were excluded. Articles were screened by 2 independent reviewers with conflicts resolved with a third reviewer. Meta-regression analysis was performed to determine the effect of time, patient age, and gender. Subgroup analysis was performed to compare geographic regions.ResultsA total of 1504 articles were identified. Data from 172 groups representing 18,644 patients recruited from 1990 to 2013 and identified from 107 articles were included. The mean preoperative Physical Component Summary score was 31.2 (95% confidence interval 30.5-31.9) with a 95% prediction interval of 22.6-39.8. The variance across studies was statistically significant (P = .000) with 97.25% true variance. Year of enrollment, age, and the percentage of females were not found to have any significant effect. There were no differences between countries.ConclusionPatients are undergoing total hip arthroplasty at a similar preoperative physical functional status as in the past. Patient age, gender, and location do not influence the functional status at which patients are indicated for surgery. 相似文献
9.
Haya Mohammed BSc MChB M. Yousuf Salmasi MRCS Massimo Caputo PhD Gianni D. Angelini PhD Hunaid A. Vohra PhD 《Journal of cardiac surgery》2020,35(6):1209-1219
Background
Limited data exists demonstrating the efficacy of minimally invasive surgery (MIS) compared to median sternotomy (MS) for multiple valvular disease (MVD). This systematic review and meta-analysis aims to compare operative and peri-operative outcomes of MIS vs MS in MVD.Methods
PubMed, Ovid, and Embase were searched from inception until August 2019 for randomized and observational studies comparing MIS and MS in patients with MVD. Clinical outcomes of intra- and postoperative times, reoperation for bleeding and surgical site infection were evaluated.Results
Five observational studies comparing 340 MIS vs 414 MS patients were eligible for qualitative and quantitative review. The quality of evidence assessed using the Newcastle-Ottawa scale was good for all included studies. Meta-analysis demonstrated increased cardiopulmonary bypass time for MIS patients (weighted mean difference [WMD], 0.487; 95% confidence interval [CI], 0.365-0.608; P < .0001). Similarly, aortic cross-clamp time was longer in patients undergoing MIS (WMD, 0.632; 95% CI, 0.509-0.755; P < .0001). No differences were found in operative mortality, reoperation for bleeding, surgical site infection, or hospital stay.Conclusions
MIS for MVD have similar short-term outcomes compared to MS. This adds value to the use of minimally invasive methods for multivalvular surgery, despite conferring longer operative times. However, the paucity in literature and learning curve associated with MIS warrants further evidence, ideally randomized control trials, to support these findings.10.
目的 采用Meta分析对比四维子宫输卵管超声造影(4D-HyCoSy)与子宫输卵管造影(HSG)评估输卵管通畅性的效能。方法 系统搜索PubMed、Cochrane Library、Embase、Web of Science、中国生物医学文献数据库、中国知网、万方医学网及维普数据库中建库至今有关4D-HyCoSy和/或HSG评估输卵管通畅性的文献。由2名研究人员依据纳入标准和排除标准筛选文献并提取信息;分别计算4D-HyCoSy和HSG评估输卵管通畅性的合并敏感度(SEN)、特异度(SPE)及诊断比值比(DOR),绘制综合受试者工作特征(SROC)曲线,获得曲线下面积(AUC),并以Medcalc 19.1.1统计软件比较AUC。结果 最终纳入19篇文献、1 358例疑似输卵管因素导致不孕患者,其中4篇同时采用4D-HyCoSy及HSG评估输卵管通畅性,10篇仅以4D-HyCoSy评估,5篇仅以HSG评估。Meta分析结果显示,4D-HyCoSy评估输卵管通畅性的合并SEN、SPE及DOR分别为0.92[95%CI(0.91,0.94)]、0.91[95%CI(0.89,0.93)]及115.06[95%CI(54.23,224.10)];HSG评估输卵管通畅性的合并SEN、SPE及DOR分别为0.84[95%CI(0.81,0.87)]、0.80[95%CI(0.76,0.83)]及28.64[95%CI(10.08,81.35)]。4D-HyCoSy评估输卵管通畅性的AUC为0.98[95%CI(0.96,0.99)],HSG为0.93[95%CI(0.90,0.95)],差异有统计学意义(Z=6.97,P<0.01)。结论 4D-HyCoSy评估输卵管通畅性的效能高于HSG。 相似文献