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排序方式: 共有362条查询结果,搜索用时 15 毫秒
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广西急性散发性病毒性肝炎的血清流行病学研究 总被引:2,自引:0,他引:2
对广西166例住院急性散发性病毒性肝炎病毒性肝炎病例进行血清流行病学调查研究,结果表明,甲型,乙型,丙型,戊型,庚型肝炎生期感染指标检出率分别为4.82%,51.20%,13.86%和11.64%,未分病例占17.42%,危险性因素分析表明,乙肝、丙肝和庚肝病人中有较高的肝病史、输血史和手术史。认为乙肝在急性散病毒性肝炎中占重要地位,医源性传播是主要传播途径 。 相似文献
3.
Summary. Germline mutations of the RET proto-oncogene localized on chromosome 10q11.2 are the underlying cause of hereditary medullary
thyroid carcinoma. In MEN 2A and FMTC, mutations can be found in exons 10, 11, 13 or 14. MEN 2B is characterized by a specific
mutation in exon 16. In a significant number of sporadic MTC somatic mutations in codon 918 (exon 16) are detectable. Some
rare sporadic MTC present somatic mutations in codons 611, 634, 768 and 883. Recently, deletion-insertion of the RET proto-oncogene
in exon 11 and a deletion in exon 10 has been found. RET proto-oncogene mutations are not only responsible for the development
of the familial MTC, but may also play an important role in the pathogenesis of sporadic MTC. However, the prognostic relevance
of these somatic events is still unclear.
相似文献
4.
Kai Dong Mengjun Shen Guanqun Ju Sha Han Zhijun Wang Kaining Lu Dongliang Xu 《European urology》2021,79(2):283-289
BackgroundPartial nephrectomy or angioembolisation is commonly used for sporadic renal angiomyolipomas (RAMLs) with high RENAL scores, but there is a risk of reduced renal function, postoperative complications, and recurrence.ObjectiveTo describe a new technique for off-clamp laparoscopic evacuation of sporadic RAMLs with high RENAL scores that promotes maximal renal function maintenance and low postoperative complication and lesion recurrence rates.Design, setting, and participantsA retrospective cohort of patients undergoing off-clamp laparoscopic evacuation for sporadic RAMLs with RENAL scores ≥9 from January 2013 to June 2018 was included.Surgical procedureWe highlighted the curettage, suction, packing, and binding (CSPB) technique, a new off-clamp retroperitoneoscopic evacuation technique for sporadic RAMLs.MeasurementsDemographics, preoperative, intraoperative, and postoperative outcomes were assessed.Results and limitationsA total of 141 cases were included. The median (interquartile range [IQR]) tumour size was 7 (6.2–8.2) cm. The median (IQR) RENAL score was 10 (9–11). The median (IQR) operative time was 80 (65–125) min, with a median (IQR) estimated blood loss of 130 (90–362.5) ml. Conversion to neither open surgery nor standard laparoscopy occurred. The warm ischaemia time was zero for all cases. Postoperatively, 13 minor complications (Clavien grade 1) were recorded. No blood transfusions were reported. The glomerular filtration rate did not change significantly from preoperative period to 12-mo follow-up. Recurrence did not occur at the median follow-up period of 48 (36–60) mo. The retrospective design and lack of a control group are limitations of this study.ConclusionsOff-clamp retroperitoneoscopic tumour evacuation using the CSPB technique is feasible, safe, and effective for treating complex sporadic RAMLs.Patient summaryWe report a curettage, suction, packing, and binding technique for off-clamp retroperitoneoscopic evacuation of sporadic renal angiomyolipomas that leads to complete lesion clearance, excellent renal function preservation, and minimal perioperative complications. 相似文献
5.
对北京铁路地区部分人群58例散发性急性非甲非乙非丙型肝炎进行了HEV和HGV血清学调查。结果如下,抗-HEV阳性22例(37.93%),抗-HGV和HGVRNA阳性共12例(20.68%),其中3例为戊型和庚型肝炎病毒混合感染。戊肝、庚肝病毒感染均以31~40岁发病最多,且男多于女;戊肝主要发生在冬春季,多有肠道暴露史;庚型肝炎病毒感染无明显季节性,有肠道外暴露史。HGV可单独感染,提示它可能有一定的致病性。 相似文献
6.
目的探讨错配修复缺陷的散发性大肠癌的临床病理特征及错配修复缺陷检测手段的应用。方法对71例散发性大肠癌行hMLH1启动子甲基化检测、微卫星不稳定检测以及hMLH1和hMSH2的免疫组化检测,分析错配修复缺陷的散发性大肠癌的临床病理特征,探讨三种检测方法的应用价值。结果hMLH1基因启动子甲基化、微卫星不稳定和错配修复蛋白表达的阳性率分别为9.9%,9.9%和71.0%,三者密切相关。hMLH1启动子甲基化和微卫星不稳定的散发性大肠癌均具有结肠癌多发和低分化腺癌相对多见的特征。错配修复蛋白表达阴性的散发性大肠癌仅具有低分化腺癌相对多见的特征。结论错配修复缺陷的散发性大肠癌具有结肠癌和低分化腺癌多发的倾向,hMLH1启动子甲基化和微卫星不稳定以及错配修复蛋白的失表达三者密切相关。 相似文献
7.
8.
Demographic and clinical characteristics of Familial Multiple Sclerosis (FMS) have not been fully investigated yet in Abu Dhabi. The aim of this single center exploratory study was to investigate demographic and clinical characteristics of FMS compared to sporadic MS (SMS) in Abu Dhabi.A chart review single center study was conducted in 98 patients with MS. Group comparisons were performed using Mann-Whitney and Chi-Square tests as appropriate. A p < 0.05 was considered statistically significant. 24.5% were patients with FMS and 83% were Emirates. No significant differences in demographic and clinical characteristics were found between patients with FMS and SMS in overall all MS patients and in the Emirati group analyzed alone.Patients with FMS did not differ in demographic and clinical characteristics compared to patients with SMS. Further prospective studies are needed to elucidate environmental and genetic risk factors contributing to FMS in the Emirati population. 相似文献
9.
《Gait & posture》2020
BackgroundOne of the research interests with regard to accelerometry is the evaluation of physical activity bout under free-living conditions.Research questionThis study aimed to examine the effect of treatment interruption on the estimation of heart rate (HR) response to moderate-to-vigorous intensity physical activity (MVPA) bout.MethodsTwenty-five young women performed at least 30 min of MVPA during 24 h while wearing a uniaxial accelerometer on their waist and a portable HR monitor on their chest simultaneously. Based on the time series data, MVPA bout was defined as physical activity that was maintained at no less than 3 metabolic equivalents (METs) for >10 min without or with interruption, i.e., a 1-, 2-, or 3-min interruption.ResultsThe frequency and duration of MVPA bout significantly increased with interruption (p < 0.01). The HR and estimated MET value for an MVPA bout with interruption were significantly lower than those without interruption (p < 0.01), and the difference gradually increased depending on the duration of the interruptions (p < 0.01).SignificanceThese findings indicate that treatment interruptions could influence the estimation of cardiorespiratory response to MVPA bout under free-living conditions, and interruptions could result in an overestimation of the actual intensity of an MVPA bout. 相似文献
10.
We evaluated the efficacy of rehabilitation therapy with Hybrid Assistive Limb® (HAL; hereafter HAL therapy) in three patients diagnosed with sporadic inclusion body myositis (sIBM) who were hospitalized to undergo HAL therapy. Among them, one patient participated in eight courses and the other two in two courses of HAL therapy between 2017 and 2020. We determined the mean rate of improvement in two-minute walking distance and 6 m walking speed at the time of hospital discharge. After HAL therapy, we confirmed the patients’ desire to continue the use of HAL. In one patient, we observed improvements of 146.0% and 120.0% in two-minute walk and 6 m walking speed, respectively, after the first course of HAL therapy; these values are 133.7% and 130% after the eighth course of HAL therapy. These values exceeded 90% in the other two patients after the second course of HAL therapy. HAL therapy maintained both quantity and quality of ambulation and showed positive psychological effects on patient conditions because it reduces exercise load and facilitates safety. While HAL therapy might be effective in maintaining and improving ambulation in patients with sIBM, we should consider to discontinue HAL therapy as it increased risk of falling. 相似文献