Malignant fibrous histiocytoma of bone

Malignant fibrous histiocytoma (MFH) of bone is a malignant primary bone tumour that is being increasingly recognised, as more details emerge in the literature regarding its natural history and precise (although sometimes diverse) histological appearance. When the whole bulk of a malignant bone tumour fits the criteria laid down, the designation of MFH seems appropriate. Seven cases of MFH of bone were encountered from a total of 220 primary malignant bone tumours in our files over a 4-year period. The metaphyses of long bones were the most common sites harbouring the tumour, and a wide age range was represented. Amputation was the treatment of choice in all cases. The relevant literature is reviewed.     

Pleomorphism of Legionella Pneumophila

Legionella pneumophila ILp), serogroups 1-6, was grown in vitro on a variety of media, in embryonated hens' eggs, and in guinea pigs. The morphology of the microbe was examined by light, immunofluorescent, and electron microscopy (transmission, scanning, negative staining). The configuration of all serogroups examined differed somewhat on agar media, in liquid media, and in vivo. Each serogroup of Lp showed pleomorphic features indistinguishable from the others. Except for filamentous forms, pleomorphism was least conspicuous on agar. By contrast, pleomorphism was most apparent in yeast extract broth, and it was detected by all of the morphologic techniques employed. Bacilli were seen most commonly, but the spectrum of forms was as follows: cocci, coccobacilli (short bacilli), medium bacilli, bacilli with terminal cocci, filamentous forms, and branches. Diplococci, branches, and stalks were only rarely seen, and the latter form was never visualized by immunofluorescence. In tissue samples from infected guinea pigs and embryonated hens' eggs, Lp was typically a short bacillus, but coc-coid and coccobacillary forms were seen. Lp is clearly a pleomorphic bacterium, particularly when grown in yeast extract broth. The variety of forms described herein might provide clues to taxonomy, ecologic niche, and physiology of Lp.     

Tumor invasion front in oral squamous cell carcinoma

Oral squamous cell carcinoma is a neoplasm that originates from the epithelial mucosa. It is usually more frequent between the fifth and sixth decades of life, and more than 90% of carcinomas of the oral cavity are squamous cell carcinoma. It is an invasive neoplasia with a significant recurrence rate; 40% of patients present with metastases in the cervical lymph nodes at the time of diagnosis. The tumor invasion front is a characteristic of tumor growth, which can be infiltrative or noninvasive. The histopathological parameters examined include the number of mitoses, depth of the tumor, invasion pattern, degree of keratinization, and nuclear pleomorphism. For the pathologist, these parameters are routinely evaluated but are not reported to the treating physician in all cases, which we consider to be useful information when determining the therapeutic route.     

探讨GABAARG2基因在癫痫耐药机制中的作用

目的探讨癫痫患者中GABAARG2基因与耐药性癫痫的关系。方法选择来本院就诊的98例癫痫患者,根据对抗癫痫药物的反应性分为耐药组(观察组)46例和敏感组(对照组)52例进行研究,提取所有患者的DNA,采用PCR基因测序鉴定GABAARG2基因出现的概率,对每一位受试者以口服传统的抗癫痫药物-苯妥英(phenytoin)方式来对比两组患者的药物口服吸收率。结果观察组和对照组之间的年龄、性别、既往病史、持续状态方面差异均无统计学意义(P0.05)。观察组出现GABAARG2基因的概率显着高于对照组,差异具有统计学意义(χ~2=8.08,P=0.01);观察组的总体口服吸收率(68.71%±12.28%)明显低于对照组的口服吸收率(82.36%±15.31%),差异具有统计学意义(χ~2=6.78,P=0.01)。结论 GABAARG2基因的在脑内的出现会影响抗癫痫药物的效果,进而引起患者的耐药性,对临床治疗有较好的参考价值。     

腮腺多形性腺瘤与腮腺浅叶腺体部分移位的临床研究

目的：研究腮腺多形性腺瘤与腮腺腺体移位的状况、关系、可能原因及临床影响。方法：通过对25例腮腺多形性腺瘤病人术中测量腮腺浅叶腺体的位置、肿瘤的部位、包膜等，从临床的角度研究腮腺腺体移位与腮腺多形性腺瘤的生物学行为的关系。结果：本组病例中36％伴有腮腺浅叶移位，特别是领后区肿瘤伴浅叶后移明显。结论：腮腺多形性腺瘤可导致腮腺移位。这可能与肿瘤起源于腮腺腺体内以及腮腺对肿瘤提供营养有关。