全文获取类型
收费全文 | 249篇 |
免费 | 34篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
基础医学 | 8篇 |
临床医学 | 8篇 |
内科学 | 15篇 |
皮肤病学 | 1篇 |
神经病学 | 1篇 |
特种医学 | 3篇 |
外科学 | 10篇 |
综合类 | 50篇 |
预防医学 | 15篇 |
眼科学 | 4篇 |
药学 | 67篇 |
中国医学 | 101篇 |
肿瘤学 | 10篇 |
出版年
2024年 | 2篇 |
2023年 | 5篇 |
2022年 | 7篇 |
2021年 | 16篇 |
2020年 | 9篇 |
2019年 | 13篇 |
2018年 | 17篇 |
2017年 | 10篇 |
2016年 | 11篇 |
2015年 | 10篇 |
2014年 | 19篇 |
2013年 | 21篇 |
2012年 | 29篇 |
2011年 | 22篇 |
2010年 | 12篇 |
2009年 | 11篇 |
2008年 | 14篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 3篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2001年 | 8篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有294条查询结果,搜索用时 15 毫秒
1.
唇香草中挥发油的理化性质研究 总被引:7,自引:0,他引:7
目的:研究维吾尔药唇香草中挥发油成分的理化性质.方法:采用化学检识、薄层层析法(TLC)、紫外光谱法对唇香草中挥发油成分进行定性分析。结果:唇香草挥发油中含有酚类、醛类、内醇类等不饱和化合物,唇香草中挥发油的薄层层析图谱、紫外光谱图具有明显特征。结论:化学检识、TLC、紫外光谱法可作为控制唇香草内在质量的方法,此方法简便、重现性好。 相似文献
2.
A review is presented about fagaronine, a benzophenanthridine alkaloid responsible for antitumoural activity. Plant source, extraction, biosynthesis, medicinal properties, especially antileukaemic activity, are described. 相似文献
3.
小叶锦鸡儿的药理作用 总被引:8,自引:0,他引:8
小叶锦鸡儿1g/kg,0.5g/kg灌胃给药明显地提高小鼠热痛阈(P<0.001),减少酒石酸锑钾所致的小鼠扭体反应次数(P<0.01),对抗二甲苯所致小鼠耳壳炎症(P<0.01),抑制蛋白加热变性(P<0.01),明显地降低氯仿诱发的小鼠室颤发生率。 相似文献
4.
目的:提取巴西甘薯叶不同极性部位(SM,SM-A,SM-B),进行抗肿瘤活性及剂量相关性研究。方法:
以体外培养的人肝癌细胞Hep3B、肺癌细胞A549、胃癌细胞MGC803为研究对象,MTS法分别测定不同极性部位
SM,SM-A,SM-B对以上各细胞株增殖活性的影响。结果:SM,SM-A,SM-B对3种肿瘤细胞均有一定的抑制作用;
SM-B活性最强,对上述各肿瘤细胞的抑制活性表现为MGC803>A549>Hep3B,其IC50分别为15.17 mg/L(P<0.05),
72.64 mg/L(P<0.05)和165.47 mg/L (P<0.05)。结论:巴西甘薯叶具有一定的抗肿瘤活性,SM-B为主要活性部位。 相似文献
5.
Om Prakash Shazia Usmani Ruchi Singh Namrata Singh Amresh Gupta Akash Ved 《Phytotherapy research : PTR》2021,35(1):63-77
Ziziphus mauritiana (Rhamnaceae), commonly known as Indian jujube, is a pharmacologically diverse medicinal plant. A plethora of active phytochemical constituents of this plant has been revealed so far, namely, berberine, quercetin, kaempferol, sitosterol, stigmasterol, lanosterol, diosgenin, and so forth. Several studies demonstrated the exploration of pharmacological potential of various parts such as fruits, leaves, and stems of the plant as antioxidant, cytotoxic, antimicrobial, anti‐diarrhoeal, antidepressant, immunomodulator, and hepatoprotective. This review gives a unique summary including phytochemistry, nutritional value, and significant pharmacological importance of Z. mauritiana. The literature search was carried out via search engine PubMed, Science Direct, and so on. The data were heterogeneous in terms of leaves, stem, roots, and fruits which were used for different experimental findings, which made the comparison a lengthy task. Study findings suggested that the extracts from this plant may possess numerous types of pharmacological activities. As the search for novel drugs from botanical sources continues, there is need for future investigations to isolate and characterize pharmacologically active agents that confer medicinal properties on Z. mauritiana, as well as to elucidate the structures of these agents by which they exert their healing properties and to scientifically validate the existing traditional practices concerning its health benefits. 相似文献
6.
利用稻瘟霉模型筛选铁刀木生物活性成分 总被引:1,自引:0,他引:1
目的利用稻瘟霉生物活性筛选模型,筛选铁刀木中具有生物活性的化学成分。方法通过观察样品引起稻瘟霉分生孢子或菌丝形态生长异常或生长抑制的情况,确定铁刀木中具有生物活性的部位以及化学成分。结果确定了铁刀木树干乙醇粗提物的生物活性部位为二氯甲烷和乙酸乙酯部位,其使稻瘟霉孢子菌丝体最小变形浓度(MMDC)分别为125、63μg·ml-1;筛选得到2个具有生物活性的化合物(CS2、CS7),其MMDC分别为63、31μg·ml-1。结论本模型首次用于铁刀木活性成分的追踪分离,应用本方法筛选天然药物活性成分,方便、快捷、成本低,显示了广阔的应用前景。 相似文献
7.
目的 研究茜草科耳草属植物水线草Hedyotis corymbosa的化学成分.方法 利用柱色谱、制备薄层色谱和重结晶进行分离纯化.通过波谱技术鉴定化合物的结构.结果 分离得到13个化合物,分别鉴定为(+)-lyo-niresinol-3a-O-β-D-glucopyranoside(Ⅰ)、槲皮素(quercetin,Ⅱ)、七叶内酯(esculetin,Ⅲ)、东莨菪内酯(scopoletin,Ⅳ)、耳草酮A(hedyotiscone A,Ⅴ)、对羟基苯甲酸(p-hydroxybenzoic acid,Ⅵ)、原儿茶酸(protocatechuic acid,Ⅶ)、香草酸(vanillic acid,Ⅷ)、丁香酸(syringie acid,Ⅸ)、(+)-催吐萝芙叶醇[(+)-vomifoliol,Ⅹ]、(-)-二氢催吐萝美叶醇[(-)-dihydrovomifoliol.Ⅺ]、S-(+)-去氢催吐萝芙叶醇[S-(+)-dehydrovomifoliol,Ⅻ]和茜素1-甲醚(aliza-rin 1-methyl ether,).结论 化合物Ⅰ~均为首次从该植物中分离得到. 相似文献
8.
Cardioprotective effect of N, α-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin (Dox)-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into three groups; two rats received distilled water in the control group, five rats in group I received varying concentration of VR treatment, and group II containing five rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks. In addition, the expression of three heart failure markers; beta major histocompatibility complex (β-MHC), atrial natriuretic peptide (ANP), and B type natriuretic peptide (BNP) were also evaluated. It was observed that the level of these markers expression decreases with an increase in VR concentration (p?0.05). The reduced GSH and SOD level were increased after VR administration, this extract also reduced the initially increased MDA level in cardiac tissue. Pharmacokinetic parameters evaluation showed that nanogel treated rats possesses a significantly increased VR plasma concentration, Cmax, Kel, t½(a), t½(el), Ka and AUC. The result of this study indicated that VR may help to lower the dosage level, and reduces the treatment course in cardiovascular diseases (CVD). Our conclusion proposes the cardio-protective ability of the isolated VR and its beneficial effect via free radical scavenging properties. 相似文献
9.
Dnyanesh Arun Limaye Anil Yashvant Nimbkar Rajeev Jain Mansoor Ahmad 《Phytotherapy research : PTR》1995,9(1):37-40
The aqueous extract of stem bark of Moriga pterygosperma (Family Moraingaceae) was investigated for its effect on various pharmacological parameters. In cardiovascular profile at lower concentrations (1–10 ng) it produced a dose dependent positive inotropic effect (n = 3, 1.29 ± 0.021 for 10 ng) and at higher concentrations (0.1–1 μg) a dose dependent negative inotropic effect (n = 3, 0.53 ± 0.033 for 1 μg) on the isolated frog heart. It also produced a dose dependent hypotensive effect on dog blood pressure (n = 3, 82 ± 0.98 for 20 mg/kg). It failed to elicit any effect on isolated guinea-pig ileum, rat stomach fundus or frog rectus abdominis muscle. 相似文献
10.