全文获取类型
收费全文 | 8156篇 |
免费 | 654篇 |
国内免费 | 115篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 88篇 |
妇产科学 | 155篇 |
基础医学 | 1243篇 |
口腔科学 | 69篇 |
临床医学 | 703篇 |
内科学 | 971篇 |
皮肤病学 | 118篇 |
神经病学 | 250篇 |
特种医学 | 141篇 |
外国民族医学 | 1篇 |
外科学 | 510篇 |
综合类 | 1310篇 |
现状与发展 | 3篇 |
一般理论 | 1篇 |
预防医学 | 1039篇 |
眼科学 | 35篇 |
药学 | 801篇 |
13篇 | |
中国医学 | 273篇 |
肿瘤学 | 1170篇 |
出版年
2024年 | 34篇 |
2023年 | 193篇 |
2022年 | 323篇 |
2021年 | 397篇 |
2020年 | 385篇 |
2019年 | 336篇 |
2018年 | 328篇 |
2017年 | 312篇 |
2016年 | 325篇 |
2015年 | 412篇 |
2014年 | 824篇 |
2013年 | 681篇 |
2012年 | 604篇 |
2011年 | 582篇 |
2010年 | 425篇 |
2009年 | 423篇 |
2008年 | 363篇 |
2007年 | 355篇 |
2006年 | 284篇 |
2005年 | 267篇 |
2004年 | 186篇 |
2003年 | 162篇 |
2002年 | 132篇 |
2001年 | 128篇 |
2000年 | 71篇 |
1999年 | 77篇 |
1998年 | 53篇 |
1997年 | 48篇 |
1996年 | 33篇 |
1995年 | 40篇 |
1994年 | 29篇 |
1993年 | 24篇 |
1992年 | 16篇 |
1991年 | 20篇 |
1990年 | 11篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有8925条查询结果,搜索用时 620 毫秒
1.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献2.
3.
《Cancer cell》2020,37(1):123-134.e5
4.
Roberto De la Plaza Llamas Jos M Ramia 《World journal of gastroenterology : WJG》2020,26(21):2682-2690
Postoperative complications(PC) are a basic health outcome, but no surgery service in the world records and/or audits the PC associated with all the surgical procedures it performs. Most studies that have assessed the cost of PC suffer from poor quality and a lack of transparency and consistency. The payment system in place often rewards the volume of services provided rather than the quality of patients' clinical outcomes. Without a thorough registration of PC, the economic costs involved cannot be determined. An accurate, reliable appraisal would help identify areas for investment in order to reduce the incidence of PC,improve surgical results, and bring down the economic costs. This article describes how to quantify and classify PC using the Clavien-Dindo classification and the comprehensive complication index, discusses the perspectives from which economic evaluations are performed and the minimum postoperative follow-up established, and makes various recommendations. The availability of accurate and impartially audited data on PC will help reduce their incidence and bring down costs. Patients, the health authorities, and society as a whole are sure to benefit. 相似文献
5.
城市血吸虫病综合防治措施的研究 总被引:1,自引:1,他引:0
目的探索快速控制城市血吸虫病流行的综合措施。方法在城市血吸虫病流行区选择3个试点现场,南津港、太平桥2个点采取以化疗为主的综合防治措施,小柳叶洲点采取以环境改造灭螺为主的综合防治措施。结果南津港点3年居民血吸虫感染率分别为2.80%、2.60%和2.24%,并发生急性血吸虫病2例;感染螺平均密度分别为0.0009、0.0027、0.0020只/0.1m2。小柳叶洲点3年无居民粪检阳性者,无急性血吸虫病例,哨鼠感染率为0,没有查到感染性钉螺。太平桥点3年居民感染率分别为1.18%、0.20%和0.26%,无急性血吸虫病例,家畜感染率分别为6.35%、3.57%和3.85%,2004年发现感染性钉螺,平均密度为0.0001只/0.1m2。结论在城市血吸虫病流行区,采取以环境改造灭螺为主、人群化疗、健康教育、药物灭螺灭蚴的综合防治措施能快速控制疫情。采取以化疗为主的综合防治措施,难以有效控制疫情。 相似文献
6.
X chromosomal and autosomal loss of heterozygosity and microsatellite instability in human cervical carcinoma 总被引:1,自引:0,他引:1
J. EDELMANN K. RICHTER C. HÄNEL† S. HERING‡ & L.-C. HORN† 《International journal of gynecological cancer》2006,16(3):1248-1253
The study analyzes tumor material and normal tissue from 27 patients with pure squamous cell carcinoma of the uterine cervix for loss of heterozygosity (LOH) and microsatellite instability (MSI) on 14 autosomal and 11 X chromosomal loci. Overall, 4-40% of the informative cases showed LOH at autosomal regions with the highest frequency at 3p (21-40%) and a marked frequency at 2q35-q37.1 (12.5%) and 17p13.3 (10%), representing regions with putative tumor suppressor gene (TSG) function. The frequency of X chromosomal LOH ranged from 4% to 20%, with a maximum at Xq28 (20%) and Xq11.2-q12 (17%), again indicating alterations in TSG. A 12% LOH was seen at Xq21.33-q22.3, a region encoding a protein with a regulatory function in the cell cycle via cyclin-dependent kinases. MSI was detected in autosomal regions in up to 7% in regions linked to the X chromosome in up to 11%, probably indicating alterations of mismatch repair mechanisms. Our results and those obtained from the literature suggest that autosomal LOH and MSI in carcinomas of the cervix uteri are predominantly found at regions with putative TSG function. Beside TSG alterations, X chromosomal LOH is probably more strongly connected to disturbances in cell cycle regulation. 相似文献
7.
Timson C Appanna Shareen H Doak Spencer A Jenkins Howard G Kynaston Timothy P Stephenson James M Parry 《International journal of urology》2007,14(6):539-544
OBJECTIVE: Tumors arising within augmentation cystoplasties are aggressive, have poor prognosis and the majority are not detected at follow-up cystoscopy. Genetic changes in tumors precede morphological abnormalities. Therefore, the aim of this study was to investigate whether genetic abnormalities detected by comparative genomic hybridization (CGH) could be used to identify those patients with augmentation cystoplasties at increased risk of tumorigenesis. METHODS: Bladder biopsy samples were obtained from 16 augmentation cystoplasty patients both distant from and near to the enterovesical anastomosis. CGH was used to detect genetic abnormalities in DNA extracted from the biopsies, archival specimens of two augmentation cystoplasties and two de novo bladder adenocarcinomas. RESULTS: A greater number of amplifications on 2p, 3q, 8q, 9p, 17p, 18pq and 20pq, were observed in bladder biopsies obtained near to the enterovesical anastomosis compared to those taken distant to the suture line. CGH of archival augmentation cystoplasty tumor DNA indicated abnormalities at several loci with amplifications at 2q, 5q, 10p and 21pq, while deletions occurred at 5p and 16p. CONCLUSIONS: The results of this study suggest that the urothelium adjacent to the bladder and/or bowel anastomosis in augmentation cystoplasties is genetically unstable. Furthermore, longitudinal studies are required to establish whether or not patients exhibiting genetic instability following augmentation cystoplasty are at greater risk of developing tumors than those with genetically stable epithelia. 相似文献
8.
医院综合效益评价案例分析 总被引:2,自引:0,他引:2
西南地区医院综合效益评价课题组 《中国医院管理》1994,14(2):32-35
运用层次分析法建立了医院综合效益评价指标体系,开发了医院综合效益九型评价图,用于显著评价结果。在此基础上进行了3个案例的评价分析。论述了通过对西南地区27所医院综合效益4年多的追踪分析所发现的共性问题,并提出了相应的管理对策。 相似文献
9.
用秩和比法对我院的10个公示病种医疗质量进行综合评价 总被引:2,自引:0,他引:2
目的对我院2005年度公示的10个病种进行医疗质量综合评价。方法采用秩和比法(RSR)进行统计分析。结果我院的10个公示病种被划分成4个医疗质量等级:老年性白内障、小儿支气管肺炎2个病种质量为优,急性阑尾炎、腹股沟疝(单侧)、子宫平滑肌瘤、剖宫产4个病种质量为良,胃大切、脑梗塞、急性心肌梗塞3个病种质量为中,脑出血1个病种质量为差。结论通过对综合指数秩和比(RSR)的计算并根据其值分级归档,反映出所研究病种之间存在着医疗质量高低的差异。控制和降低本院临床常见病种的医药费用,进行医疗全程连续性控制,为患者提供经济有效的医疗服务。 相似文献
10.
应重视口腔颌面部恶性肿瘤的综合序列治疗 总被引:11,自引:2,他引:9
口腔颌面部恶性肿瘤约占全身恶性肿瘤的3%,虽然所占比例不高,但l大l其解剖部位特殊.涉及美观和重要的生理功能,冈此对患者机体和心理的影响不容忽视。早期(Ⅰ、Ⅱ期)口腔颌面部恶性肿瘤无论采用手术和(或)放射治疗,均能取得良好效果。但遗憾的是,大多数患者就诊时,已属局部一区域晚期(Ⅲ、Ⅳ期)。由于受到局部解剖和维持功能的限制,单纯通过扩大手术切除范围和改进现有手术技术,除能改善患者生存质量外,已无法提高此类患者的生存率,延长其生存时间。 相似文献