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1.
胃癌组织中KAI1、nm23及P53的表达及其临床意义 总被引:5,自引:4,他引:1
目的:探讨正常胃黏膜、不典型增生胃黏膜及癌组织中KAI1、nm23及P53蛋白的表达.方法:应用SP法免疫组化检测22例正常胃黏膜,65例不典型增生胃黏膜及74N胃癌组织中的KAI1、nm23及P53蛋白的表达.结果:正常胃黏膜、不典型增生胃黏膜及胃癌组织中,KAI1和nm23阳性率呈降低趋势,组间差异性有统计学意义(x2=20.885, P<0.001;x2=29.133,P<0.05):P53蛋白阳性表达率呈增加趋势,组间差异性有统计学意义(x2=21.954,P<0.001).Fisher精确概率检验显示:在胃癌组中不同的浸润深度、有无淋巴结转移和脉管侵犯组内KAI1、nm23及 P53组阳性表达率的差异性有统计学意义(x2 =20.885,P<0.001;x2=29.133,P<0.05;x2= 21.954,P<0.001);而在年龄、性别组间的差异性无统计学意义.Spearman等级相关分析显示 KAI1与nm23表达呈正相关(r=0.859,P<0.05); KAI1与P53表达呈负相关(r=-0.859,P<0.05), nm23与P53表达呈负相关(r=-0.874,P<0.05) 结论:抑癌基因KAI1与nm23的缺失以及P53 蛋白的过表达可能是胃癌发生、发展及浸润和转移的重要原因之一. 相似文献
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蔡子谔 《南通大学学报(哲学社会科学版)》2000,(4)
新近面世的《陈辽文存》显示了南通籍著名文学评论家陈辽先生学术研究的独特个性 ,即研究对象的整体性 ,研究成果的创新性 ,研究方向的前瞻性和研究方法的兼容性。 相似文献
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陈亦人教授运用芍药甘草汤的经验 总被引:4,自引:0,他引:4
芍药甘草汤具有养阴血、柔筋脉、舒挛缓急的功效,主治筋脉挛急之证。介绍陈亦人教授运用芍药甘草汤的经验,并附验案分析。 相似文献
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陈宪海教授根据外感病的临床传变特点,结合外感肺病的病机以及病情演变规律,联系整体观念以及脏腑相关理论,认为外感肺病在临床辨证治疗中应注重层次性,即外围层次、本脏层次、子母层次。在不同层次给予不同治疗,在表者宜解表驱邪,方以参苏饮加减;在肺者清肃肺气,方以三拗汤加减;及脾者宜健脾化痰,方以四君子汤加减。各层次治疗重点不同,选方用药精良,临床随症灵活加减,恢复肺之宣降功能,临床疗效较好。 相似文献
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Background
People with prehypertension are highly likely to develop hypertension and other cardiovascular diseases. Lifestyle modifications may prevent hypertension in patients with prehypertension, but evidence remains scarce in developing countries. This study aimed to investigate whether a community-based intervention could prevent hypertension through lifestyle modifications in people with prehypertension in the rural areas of China.Methods
A community-based quasi-experiment design was applied. Eighteen villages from six townships in Sheyang county, a rural area in eastern China, were randomly sampled. Of these local residents, patients with prehypertension—a systolic blood pressure (SBP) of 120–139 mm Hg or a diastolic blood pressure (DBP) of 80–89 mm Hg—and who were 30–60 years old were screened. Participants from three of the townships (n=206) were randomly assigned to the intervention group, and those from the other three townships (n=250) were assigned to the control group. At the outset, intervention group participants received individual consultations from a community health management team to assess their self-management ability, determine their lifestyle, set goals for a healthier lifestyle, and design individualised action plans. A guideline booklet was provided to intervention group participants, which contained detailed explanations of hypertension, prehypertension, healthy lifestyles and their impacts, and methods to lose weight, cease smoking, and deal with mental pressure. Intervention group participants also received quarterly follow-ups to assess the implementation of action plans, identify difficulties in changing unhealthy lifestyles, and find feasible solutions. In both intervention and control groups, usual care was provided to participants according to national guidelines, and the available resources were the same across the townships. Evaluations were conducted at baseline, and at the end of months 6, 12, 18, and 30. Between-group analyses were performed using repeated measures ANOVA. Written informed consent was obtained from the participants.Findings
At 30 months, 18 participants in the intervention group (n=188) showed progression to hypertension, whereas 47 in the control group (n=234) developed hypertension. This difference between intervention and control groups was statistically significant (9·6 vs 20·1%, p=0·007). Significant changes in DBP (–2·7 vs 0·7 mmHg, p<0·0001), weight (–0·79 vs ?0·66 kg, p=0·029), and daily walking steps (11?500 vs 8000 steps, p<0·0001) were observed between intervention and control groups. No differential effects were found for SBP, drinking, and smoking, with both groups showing substantial improvements.Interpretation
This intervention could prevent hypertension among patients with prehypertension by improving health-related behaviours. This study might be one of the first community-based experiments implemented among people with prehypertension in the rural areas of China. Further investigations are required to assess the sustainability of this intervention.Funding
This study was funded by the Postgraduates Innovation Project of Jiangsu Province (KYZZ15_0267). 相似文献9.
介绍陈定潜主任医师治疗内科病症的经验,重视湿毒致病,提倡缓图法及分阶段治疗,强调用药须注重保护胃气。 相似文献
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