收费全文 | 60504篇 |
免费 | 4388篇 |
国内免费 | 2137篇 |
耳鼻咽喉 | 382篇 |
儿科学 | 1409篇 |
妇产科学 | 740篇 |
基础医学 | 9010篇 |
口腔科学 | 792篇 |
临床医学 | 4607篇 |
内科学 | 9429篇 |
皮肤病学 | 1160篇 |
神经病学 | 4806篇 |
特种医学 | 861篇 |
外国民族医学 | 11篇 |
外科学 | 4442篇 |
综合类 | 6406篇 |
现状与发展 | 10篇 |
预防医学 | 4920篇 |
眼科学 | 997篇 |
药学 | 10345篇 |
8篇 | |
中国医学 | 3069篇 |
肿瘤学 | 3625篇 |
2023年 | 875篇 |
2022年 | 1498篇 |
2021年 | 1915篇 |
2020年 | 1809篇 |
2019年 | 2396篇 |
2018年 | 2348篇 |
2017年 | 1977篇 |
2016年 | 1900篇 |
2015年 | 2100篇 |
2014年 | 3279篇 |
2013年 | 4016篇 |
2012年 | 3405篇 |
2011年 | 4057篇 |
2010年 | 3383篇 |
2009年 | 2797篇 |
2008年 | 2648篇 |
2007年 | 2482篇 |
2006年 | 2107篇 |
2005年 | 1839篇 |
2004年 | 1638篇 |
2003年 | 1513篇 |
2002年 | 1244篇 |
2001年 | 1091篇 |
2000年 | 835篇 |
1999年 | 849篇 |
1998年 | 698篇 |
1997年 | 649篇 |
1996年 | 556篇 |
1995年 | 489篇 |
1994年 | 437篇 |
1993年 | 409篇 |
1992年 | 371篇 |
1991年 | 348篇 |
1990年 | 307篇 |
1989年 | 247篇 |
1988年 | 244篇 |
1986年 | 185篇 |
1985年 | 806篇 |
1984年 | 1036篇 |
1983年 | 821篇 |
1982年 | 944篇 |
1981年 | 888篇 |
1980年 | 662篇 |
1979年 | 619篇 |
1978年 | 444篇 |
1977年 | 356篇 |
1976年 | 408篇 |
1975年 | 311篇 |
1974年 | 193篇 |
1973年 | 196篇 |
2. Firstly, cell viability and biochemical indicators were determined and the cell morphology was observed to confirm the cell injury and develop a cell hepatotoxicity model. Then, with the help of cell metabolomics based on UPLC-MS, the Genkwa Flos group samples were completely separated from the blank group samples in the score plots and seven upregulated as well as two down-regulated putative biomarkers in the loading plot were identified and confirmed. Besides, two signal molecules and four enzymes involved in biosynthesis pathway of lysophosphatidylcholine and the sphingosine kinase/sphingosine-1-phosphate pathway were determined to investigate the relationship between Genkwa Flos hepatotoxicity and these two classic pathways. Finally, the metabolic pathways related to specific biomarkers and two classic metabolic pathways were analyzed to explain the possible mechanism of Genkwa Flos hepatotoxicity.
3. Based on the results, lipid peroxidation and oxidative stress, phospholipase A2/lysophosphatidylcholine pathway, the disturbance of sphingosine-1-phosphate metabolic profile centered on sphingosine kinase/sphingosine-1-phosphate pathway and fatty acid metabolism might be critical participators in the progression of liver injury induced by Genkwa Flos. 相似文献
Areas covered: This article covers the pharmacokinetics and pharmacodynamics of vilazodone and provides an evaluation of the clinical usefulness of vilazodone for the treatment of MDD and anxiety disorders. A literature search was performed using PubMed/MEDLINE, Web of Science and the Cochrane Library.
Expert opinion: Studies have shown that vilazodone is significantly superior to placebo. However, vilazodone cannot as yet be recommended as a first-line treatment option for MDD as it is unclear whether the drug’s dual mechanism of action provides greater efficacy than prevailing treatment options. Moreover, more phase IV studies are needed to establish its efficacy and long-term safety in larger and more diverse populations. Although vilazodone may have an additional advantage for the treatment of anxiety symptoms in MDD, here also additional studies are required to confirm its efficacy over and above SSRI alternatives and other antidepressant treatments. Therefore, presently, vilazodone should be considered as a second- or third-line treatment option for MDD and GAD. 相似文献