全文获取类型
收费全文 | 4558篇 |
免费 | 306篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 97篇 |
妇产科学 | 48篇 |
基础医学 | 231篇 |
口腔科学 | 15篇 |
临床医学 | 770篇 |
内科学 | 1722篇 |
皮肤病学 | 7篇 |
神经病学 | 181篇 |
特种医学 | 213篇 |
外国民族医学 | 1篇 |
外科学 | 295篇 |
综合类 | 508篇 |
预防医学 | 251篇 |
眼科学 | 50篇 |
药学 | 329篇 |
1篇 | |
中国医学 | 154篇 |
肿瘤学 | 29篇 |
出版年
2024年 | 6篇 |
2023年 | 125篇 |
2022年 | 170篇 |
2021年 | 271篇 |
2020年 | 218篇 |
2019年 | 299篇 |
2018年 | 257篇 |
2017年 | 137篇 |
2016年 | 133篇 |
2015年 | 122篇 |
2014年 | 335篇 |
2013年 | 314篇 |
2012年 | 196篇 |
2011年 | 228篇 |
2010年 | 174篇 |
2009年 | 164篇 |
2008年 | 180篇 |
2007年 | 223篇 |
2006年 | 131篇 |
2005年 | 136篇 |
2004年 | 116篇 |
2003年 | 88篇 |
2002年 | 81篇 |
2001年 | 75篇 |
2000年 | 56篇 |
1999年 | 58篇 |
1998年 | 49篇 |
1997年 | 64篇 |
1996年 | 50篇 |
1995年 | 37篇 |
1994年 | 45篇 |
1993年 | 35篇 |
1992年 | 37篇 |
1991年 | 33篇 |
1990年 | 26篇 |
1989年 | 29篇 |
1988年 | 34篇 |
1987年 | 21篇 |
1986年 | 25篇 |
1985年 | 30篇 |
1984年 | 25篇 |
1983年 | 30篇 |
1982年 | 22篇 |
1981年 | 19篇 |
1980年 | 6篇 |
1979年 | 10篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1975年 | 4篇 |
排序方式: 共有4948条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
《Journal of vascular and interventional radiology : JVIR》2020,31(3):378-387
PurposeTo determine if cone-beam CT and digital subtraction angiography analysis of pelvic arterial anatomy has predictive value for radiation exposure and technical success of prostatic artery embolization (PAE).Materials and MethodsThis prospective, nonrandomized, single-center study included 104 consecutive patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia. Cone-beam CT was performed in 160/208 (76.9%) hemipelves to determine prostatic artery (PA) origin. Classification of pelvic arterial tortuosity was possible in 73/104 (70.2%) patients. Learning curves of 2 interventionalists who performed 86.5% of PAEs were analyzed.ResultsTortuosity of pelvic arteries was classified as mild in 25 (34.2%) patients median age 64 years, moderate in 40 (54.8%) patients median age 69 years, and severe in 8 (11.0%) patients median age 70 years (mild vs moderate, P = .002; mild vs severe, P = .019); median fluoroscopy times were 24, 36, and 46 minutes (P = .008, P = .023); median contrast volumes were 105, 122.5, and 142 mL (P = .029, P = .064); and bilateral PAE rates were 84.0%, 77.5%, and 62.5% (P = .437), respectively. PA origin from superior vesical artery was most frequent (27.5%) and showed higher dose area product (median 402.4 vs 218 Gy ∙ cm2, P = .033) and fluoroscopy time (median 42.5 vs 27 min, P = .01) compared with PA origin from obturator artery, which was least frequent. Interventionalist experience revealed significant impact on procedure times (median 159 vs 130 min, P = .006).ConclusionsTortuosity of pelvic arteries was more frequent in older patients and predicted worse technical outcomes of PAE. PA origin from obturator artery was associated with lower dose area product and fluoroscopy time, especially compared with PA origin from superior vesical artery. Interventionalist experience showed significant influence on technical outcome. 相似文献
6.
7.
8.
Evaluation of training nurses to perform semi‐automated three‐dimensional left ventricular ejection fraction using a customised workstation‐based training protocol
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
9.
10.
《Journal of pharmaceutical sciences》2019,108(10):3425-3433
This study aimed at evaluating how encapsulation in a regular nanocarrier (NC) (providing extended circulation time) or in a brain-targeting NC (providing prolonged circulation time and increased brain uptake) may influence the therapeutic index compared with the unformulated drug and to explore the key parameters affecting therapeutic performance using a model-based approach. Pharmacokinetic (PK) models were built with chosen PK parameters. For a scenario where central effect depends on area under the unbound brain concentration curve and peripheral toxicity relates to peak unbound plasma concentration, dose-effect and drug-side effect curves were constructed, and the therapeutic index was evaluated. Regular NC improved the therapeutic index compared with the unformulated drug due to reduced peripheral toxicity, while brain-targeting NC enhanced the therapeutic index by lowering peripheral toxicity and increasing central effect. Decreasing drug release rate or systemic clearance of NC with drug still encapsulated could increase the therapeutic index. Also, a drug with shorter half-life would therapeutically benefit more from a NC encapsulation. This work provides insights into how a NC for brain delivery should be optimized to maximize the therapeutic performance and is helpful to predict if and to what extent a drug with certain PK properties would obtain therapeutic benefit from nanoencapsulation. 相似文献