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为增加石菖蒲挥发油的溶解度,该研究拟将其制成自纳米乳制剂。通过相容性研究、辅料配伍试验、伪三元相图的绘制初步筛选处方,以粒径、载药量为指标,采用Box-Behnken效应面法优化处方,并对最优处方的自纳米乳制剂进行表征、体外溶出评价。结果显示,石菖蒲挥发油自纳米乳的最优处方为:41. 7%石菖蒲挥发油、46. 8%聚氧乙烯脱水山梨醇单油酸酯、11. 5%PEG-400;所制得的自纳米乳澄清透明,载药量为(192. 77±1. 64) mg·g-1,粒径为(53. 20±0. 94) nm,PDI为0. 230±0. 013,Zeta电位为(-12. 2±0. 7) m V;在体外溶出度实验中,石菖蒲挥发油自纳米乳明显高于石菖蒲挥发油。该研究中石菖蒲挥发油直接作为自纳米乳中的油相,处方更简单且载药量更高,制得的自纳米乳符合相关的质量要求,为挥发油的制剂研究提供了一定的参考。 相似文献
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《Saudi Pharmaceutical Journal》2023,31(6):889-903
The present study aimed to evaluate the impact of ultrafine nanoemulsions on the transdermal delivery of lornoxicam (LOR) for management of the inflammation. The transdermal administration of LORNE could increase the efficacy of LOR with a reduction in side effects. Merging the beneficial properties of ultrafine nanoemulsions and their components (penetration enhancers) can lead to good solubilization, a small droplet size, and more effective LOR carriers. Therefore, this study aims to develop and evaluate the potential use of ultrafine nanoemulsions of LOR (LORNE) to elucidate their skin targeting for the treatment of inflammation. Based on solubility and pseudo ternary phase diagram tests, ultrafine LORNE composed of Labrafil M 2125 CS, Cremophor RH40, and Transcutol HP to deliver LOR was developed and characterized for its physicochemical properties, emulsification, and in vitro release. The selected LORNE was incorporated into carbopol gel (LORNE-Gel) and examined for ex vivo skin permeation, retention, dermatokinetics, anti-inflammatory efficacy, and skin irritation. The selected LORNE12-Gel could improve skin permeation, retention, and dermatokinetic results significantly (p < 0.05) with enhanced CSkin max and AUC0-48h compared to LOR-Gel. Moreover, LORNE12-Gel showed a remarkable anti-inflammatory effect compared to LOR-Gel after topical application. No signs of skin irritation were observed following treatment, indicating the safety of LORNE12-Gel. Thus, this study demonstrated that LOR-loaded LORNE12-Gel could be promising as an efficient transdermal nanocarrier for an anti-inflammatory alternative. 相似文献
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