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1.
欧洲药品局(EMA)于2018年11月发布了"人用药品辅料右旋糖酐的包装说明书资料",该文件引用大量文献全面评价了右旋糖酐的安全性,特别指出含有右旋糖酐辅料的注射和吸入制剂的疫苗与药品,应在说明书中描述有关其过敏反应信息的新要求。介绍该文件的主要内容,期望对我国这类药品说明书的撰写和监管有所帮助。 相似文献
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Jeroen M. van de Pol Jurjen G. Geljon Svetlana V. Belitser Geert W.J. Frederix Anke M. Hövels Marcel L. Bouvy 《Research in social & administrative pharmacy》2019,15(1):70-76
Introduction
The nature of community pharmacy is changing, shifting from the preparation and distribution of medicines to the provision of cognitive pharmaceutical services (CPS); however, often the provision of traditional services leaves little time for innovative services. This study investigated the time community pharmacists spend on the tasks and activities of daily practice and to what extent they are able to implement CPS-related services in daily practice.Methods
Self-reporting work sampling was used to register the activities of community pharmacists. A smartphone application, designed specifically for this purpose, alerted participants to register their current activity five times per working day for 6 weeks. Participants also completed an online survey about baseline characteristics.Results
Ninety-one Dutch community pharmacists provided work-sampling data (7848 registered activities). Overall, 51.5% of their time was spent on professional activities, 35.4% on semi-professional activities, and 13.1% on non-professional activities. The proportion of time devoted to CPS decreased during the workweek, whereas the time spent on traditional task increased.Discussion and conclusion
This study shows it is feasible to collect work-sampling data using smartphone technology. Community pharmacists spent almost half of their time on semi-professional and non-professional activities, activities that could be delegated to other staff members. In practice, the transition to CPS is hampered by competing traditional tasks, which prevents community pharmacists from profiling themselves as pharmaceutical experts in daily practice. 相似文献4.
A. Farina 《Journal of pharmaceutical and biomedical analysis》1989,7(12):1579-1583
A simple and rapid fluorimetric method for the determination of 9-fluoro-10-[N-(4′-methyl)piperazinyl]-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-d,e][1–4]benzothyazin-6-carboxylic acid hydrochloride (MF 934), in serum and in pharmaceutical formulations, has been developed based on its strong fluorescence, in 0.1 N H2SO4, at 526 nm (excitation wavelength at 340 nm). The procedure which involves the direct dilution of the sample requires only a few minutes and the sample volume is only 20–100 μl of serum, depending on the drug concentration. Tedious sample preparation procedures such as extraction, deproteinization, or centrifugation are not necessary. The minimum concentration that can be detected is 0.3 ng ml−1, the standard curve in 0.1 N H2SO4 was found to be linear from 0.005 to 1.5 μg ml−1 and from 0.01 to 0.07 g in plasma after dilution with 0.1 N H2SO4. 相似文献
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报告了从辽宁省部分地区腹泻和感染标本中检出的成团肠杆菌、非脱羧勒克氏菌、克吕沃尔氏菌、彭氏变形菌、霍堆氏肠杆菌的分离、鉴定,药敏试验及致病性研究结果.部分菌株可引起动物、生物模型病变,证明有致病力.与人的腹泻和感染有关.致病性研究中,溶血性阳性率最高,依次为乳鼠灌胃,HeP—2细胞、Vero细胞病变,兔肠袢结扎.豚鼠角膜侵袭试验无阳性.药敏试验证实,5组细菌抗药谱已很广,临床可用的敏感药物不多,一旦发生感染,治疗将十分困难. 相似文献
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R W Tennant 《Environmental and molecular mutagenesis》1991,18(4):322-323
The development of transgenic mouse lines with target genes that are suitable for tissue-specific mutagenesis studies is an important contribution to the field of environmental mutagenesis. These models can accommodate many of the questions relating to metabolism, distribution and relative potency of mutagens as well as providing a more comprehensive system for the identification of mutagens. However, the lesions that the field has learned about methods, development and validation from the use of in vitro systems must be applied to the development and validation of transgenic models. 相似文献
9.
It has recently been shown that it is possible to discriminate accurately among myoelectric signals underlying different muscle
contraction types, specifically elbow flexion and extension and forearm pronation and supination. It was reported that once
a number of distinctive features had been extracted from the myoelectric signals, a neural network could be trained to distinguish
the contraction types with an impressively high accuracy. In the present paper, we show that a technique known as parallel
cascade identification can be used to construct classifiers that can also accurately, differentiate the contraction types.
The use of parallel cascades has the benefit of dispensing with the need for feature extraction, so that raw myoelectric signal
data can be used directly. In addition, very little data are required to train the parallel cascades to distinguish accurately
novel incoming myoelectric signals. Results of using parallel cascades to distinguish foream pronation, supination, and elbow
flexion are presented. 相似文献
10.
对定坤丹(蜜丸)进行了显微鉴定研究,将29种组成药物全部检出,对各组成药物的显微鉴别特征作了简明描述,并附显微特征图。 相似文献