全文获取类型
收费全文 | 27377篇 |
免费 | 2684篇 |
国内免费 | 1420篇 |
专业分类
耳鼻咽喉 | 270篇 |
儿科学 | 300篇 |
妇产科学 | 463篇 |
基础医学 | 5778篇 |
口腔科学 | 507篇 |
临床医学 | 1472篇 |
内科学 | 3208篇 |
皮肤病学 | 593篇 |
神经病学 | 1319篇 |
特种医学 | 403篇 |
外国民族医学 | 14篇 |
外科学 | 1727篇 |
综合类 | 4069篇 |
现状与发展 | 6篇 |
预防医学 | 743篇 |
眼科学 | 248篇 |
药学 | 2791篇 |
2篇 | |
中国医学 | 664篇 |
肿瘤学 | 6904篇 |
出版年
2024年 | 77篇 |
2023年 | 427篇 |
2022年 | 855篇 |
2021年 | 1061篇 |
2020年 | 859篇 |
2019年 | 661篇 |
2018年 | 602篇 |
2017年 | 686篇 |
2016年 | 705篇 |
2015年 | 994篇 |
2014年 | 1353篇 |
2013年 | 1410篇 |
2012年 | 1281篇 |
2011年 | 1649篇 |
2010年 | 1459篇 |
2009年 | 1533篇 |
2008年 | 1539篇 |
2007年 | 1580篇 |
2006年 | 1424篇 |
2005年 | 1408篇 |
2004年 | 1331篇 |
2003年 | 1288篇 |
2002年 | 1116篇 |
2001年 | 1035篇 |
2000年 | 937篇 |
1999年 | 739篇 |
1998年 | 643篇 |
1997年 | 558篇 |
1996年 | 458篇 |
1995年 | 384篇 |
1994年 | 241篇 |
1993年 | 185篇 |
1992年 | 114篇 |
1991年 | 97篇 |
1990年 | 57篇 |
1989年 | 59篇 |
1988年 | 65篇 |
1987年 | 42篇 |
1986年 | 48篇 |
1985年 | 61篇 |
1984年 | 70篇 |
1983年 | 34篇 |
1982年 | 57篇 |
1981年 | 44篇 |
1980年 | 50篇 |
1979年 | 33篇 |
1978年 | 32篇 |
1977年 | 34篇 |
1976年 | 24篇 |
1975年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Primary cutaneous anaplastic large cell lymphomas with 6p25.3 rearrangement exhibit particular histological features 下载免费PDF全文
2.
4.
5.
6.
Zheyuan Wang Zhiheng Shi Lu Zhang Huihan Zhang Yawu Zhang 《Pathology, research and practice》2019,215(3):499-505
Profilin 1 (PFN1) is a critical actin-regulatory protein; however, its functional role in hepatocellular carcinoma (HCC) progression remains to be further elucidated. In the present study, we observed that the expression levels of PFN1 were significantly decreased in HCC tissues and cell lines. Low PFN1 expression was significantly correlated with aggressive clinicopathological characteristics and poor prognosis of HCC patients. Further in vitro experiments demonstrated that overexpression of PFN1 remarkably inhibited the proliferation, migration, invasion and EMT of HCC cells. Moreover, we also found that PFN1 was a direct target gene of miR-19a-3p, and in HCC tissues, and there was a significantly inverse correlation between PFN1 mRNA and miR-19a-3p expression. Collectively, our results showed that PFN1 functions as a tumor suppressor in HCC, and might serve as a diagnostic and therapeutic target for HCC patients. 相似文献
7.
《European journal of medical genetics》2020,63(6):103919
Neuronal growth regulator 1 (NEGR1), a member of the immunoglobulin superfamily cell adhesion molecule subgroup IgLON, has been involved in neuronal growth and connectivity. Genetic variants, in or near the NEGR1 locus, have been associated with obesity and, more recently, with learning difficulties, intellectual disability, and psychiatric disorders.Here, we described the only second report of NEGR1 gene disruption in 1p31.1 microdeletion in two patients. Patient 1 is a 14-year-old female with neurological and psychiatric features present also in her family. Patient 2 is a 5-month-old infant showing global hypotonia as unique neurological features till now. This patient also carries 7p22.1 duplication, of paternal origin, that could be responsible for some malformations present in the child.We hypothesize a role of NEGR1 in producing the phenotype of our patients and compare them with other cases previously reported in the literature and DECIPHER database to better identify a possible genotype-phenotype correlation. 相似文献
8.
9.
目的总结应用踇甲皮瓣再造拇指及腓动脉穿支皮瓣游离移植修复足部供区的手术方法及临床效果。方法2016 年 6 月—2018 年 5 月,应用踇甲皮瓣联合腓动脉穿支皮瓣游离移植再造拇指并修复足部供区 15 例。男 10 例,女 5 例;年龄 21~48 岁,平均 34.6 岁。致伤原因:重物压砸伤 7 例,机器绞伤 5 例,电锯切割伤 3 例。Ⅰ度缺损 9 例,Ⅱ度缺损 6 例。入院至皮瓣手术时间 4~7 d,平均 5.2 d。结果术后踇甲皮瓣及腓动脉穿支皮瓣全部成活,切口均Ⅰ期愈合。患者均获随访,随访时间 8~24 个月,平均 16.4 个月。末次随访时,再造拇指指甲生长平整,有光泽,指腹饱满;足部皮瓣外形良好,颜色及质地接近受区。根据中华医学会手外科学会拇手指再造功能评定标准,获优 9 例、良 6 例;根据 Maryland 足功能评分标准,获优 10 例、良 5 例。患者行走步态正常,无跛行及疼痛不适。结论踇甲皮瓣修复拇指Ⅰ、Ⅱ度缺损,再造拇指可获得良好外观及功能;腓动脉穿支皮瓣具有血供可靠、血管恒定、易切取等优点,可有效修复足部供区。 相似文献
10.
Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma 下载免费PDF全文
Georgia Levidou Dimitrios Theodorou Nikolaos V. Michalopoulos Efstratios Patsouris Angelica A. Saetta 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(8):639-647
Among the numerous signaling pathways involved in tumorigenesis, PI3K‐AKT‐mTOR is a key one that regulates diverse cellular functions. However, its prognostic value in esophageal carcinoma remains unclear. In our study, we examined the immunohistochemical expression of phosphorylated (p‐) AKT, mTOR, p70S6K and 4E‐BP1 along with the mutational status of PIK3CA and AKT1 genes by High Resolution Melting Analysis and Pyrosequencing in 44 esophageal carcinomas. The results were correlated with the clinicopathological characteristics of the patients in an effort to define their possible prognostic significance. Total p‐mTOR cytoplasmic expression, assessed in 10 random areas, was positively correlated with tumor stage (Kruskal–Wallis ANOVA, I/II vs III/IV, p = 0.0500). Μoreover, maximum p‐mTOR cytoplasmic immunoexpression, estimated in hot spot areas, was positively associated with tumor grade (Mann–Whitney U test, I/II vs III, p = 0.0565). Interestingly, p‐4E‐BP1 immunoreactivity was negatively correlated with tumor histological grade (Mann–Whitney U test, I/II vs III, p = 0.0427). No mutation was observed in exons 9 and 20 of PIK3CA gene and in exon 4 of AKT1 gene. In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathway in esophageal cancer bringing forward p‐mTOR and p‐4E‐BP1 for their potential role in esophageal carcinogenesis. Additional studies are warranted to validate our findings. 相似文献