白簕叶的化学成分研究

从大齿山芹根中分得11个结晶,鉴定了9个:肉豆蔻酸、棕榈酸、硬脂酸、二十八烷酸、丁二酸、β-谷甾醇、胡萝卜甙、异东莨菪素和蔗糖。本结果为植物分类学的研究提供化学依据。     

石吊兰素对麻醉猫血流动力学的影响

本文研究了石吊兰素对麻醉开胸猫血流动力学的影响。结果表明：石吊兰素2．5mg／kgiv降压时伴有左室内压峰值及外周阻力下降；5mg／kg使外周阻力及血压进一步降低，舒张压的下降超过收缩压，心率减慢，心输出量及左室内压上升速率峰值等均见明显降低。低剂量的石吊兰素的降压作用主要系舒张血管所致，石吊兰素较大剂量对心脏的抑制作用可能也参与了其降压成分     

白簕叶的化学成分研究

自五加科植物白簕的叶中分离到石吊兰素(A),贝壳杉烯酸(B),蒲公英萜醇(C)及其乙酸酯(D)。其中A、B在该植物中是首次分离到。药理实验表明A具有祛痰、止咳作用。     

Inhibition of methyleugenol bioactivation by the herb-based constituent nevadensin and prediction of possible in vivo consequences using physiologically based kinetic modeling

Methyleugenol (ME) occurs naturally in a variety of spices, herbs, including basil, and their essential oils. ME induces hepatomas in rodent bioassays following its conversion to a DNA reactive metabolite. In the present study, the basil constituent nevadensin was shown to be able to inhibit SULT-mediated DNA adduct formation in HepG2 cells exposed to the proximate carcinogen 1′-hydroxymethyleugenol in the presence of nevadensin. To investigate possible in vivo implications of SULT inhibition by nevadensin on ME bioactivation, the rat physiologically based kinetic (PBK) model developed in our previous work to describe the dose-dependent bioactivation and detoxification of ME in male rat was combined with the recently developed PBK model describing the dose-dependent kinetics of nevadensin in male rat. The resulting binary ME–nevadensin PBK model was used to predict the possible nevadensin mediated reduction in ME DNA adduct formation and resulting carcinogenicity at the doses of ME used by the NTP carcinogenicity study. Using these data an updated risk assessment using the Margin of Exposure (MOE) approach was performed. The results obtained point at a potential reduction of the cancer risk when rodents are orally exposed to ME within a relevant food matrix containing SULT inhibitors compared to exposure to pure ME.