Nine new compounds from the whole plants of Rehmannia henryi

Eight new iridoids (1–8) and an ionone glucoside (9), together with 31 known compounds (10–40), were isolated from the whole plants of Rehmannia henryi. The structures of these compounds were elucidated on the basis of their spectroscopic data and chemical evidence.     

Nine new compounds from the whole plants of Rehmannia chingii

Nine new compounds, together with 16 known analogs, were isolated from the whole plants of Rehmannia chingii. The structures of compounds 1–9 were elucidated on the basis of their spectroscopic data and chemical evidence. In addition, the new compounds were tested for their hepatoprotective activities against APAP-induced HepG2 cell damage and their ability to inhibit LPS-induced nitric oxide production in the murine microglia BV2 cell line. Compounds 2 and 5 exhibited pronounced hepatoprotective activities against APAP-induced HepG2 cell damage at a concentration of 10 μM, and compounds 4 and 9 showed moderate inhibitory activity against microglial inflammation factor with IC₅₀ values of 3.51 and 7.11 μM, respectively.     

紫罗兰酮酰胺衍生物的合成与抗肿瘤转移活性研究

目的:研究紫罗兰酮酰胺衍生物的合成与抗肿瘤转移活性。方法:以α-紫罗兰酮为原料,经卤仿反应、烯丙位氧化反应和酰胺化反应得到目标化合物2a-f和4a-f,所有衍生物均评价其抗肿瘤转移活性。结果:合成得到两个系列共12个紫罗兰酮酰胺衍生物,所有化合物都经过¹H NMR 、¹³C NMR和ESI-MS 表征了化学结构。与阳性对照化合物LY204002相比,化合物4f具有较强的抗肿瘤转移的活性。结论:紫罗兰酮酰胺衍生物中叔胺基团和3位羰基很可能是发挥抗肿瘤转移作用的必需基团。     

地黄化学成分和药理作用的研究进展

地黄Rehmannia glutinosa为我国民间传统植物药,有着久远的历史记载,主产于河南、河北、陕西、山西等地.其化学成分类型主要包括环烯醚萜类、紫罗兰酮类、苯乙醇苷类、三萜类、黄酮类及糖类等,对人体血液系统、心脑血管系统、中枢神经系统和免疫系统有显著作用.随着现代分离分析手段的不断创新,加之现代科学技术与药理学...     

A new ionone derivative from the leaves of Picrasma quassioides

Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2–9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.     

手性紫罗兰酮生物碱衍生物Ion-31a的制备方法优化

目的:新型手性紫罗兰酮生物碱衍生物Ion-31a对MDA-MB-231乳腺癌细胞具有抗转移作用,原有文献报道该化合物的产率很低。该文旨在对Ion-31a合成路线进行优化,以提高产率为深入进行新药研究提供大量化合物。方法:以洋葱假单胞菌中获取的脂肪酶为酶促拆分剂,通过酶-化学拆分法代替原路线的结晶拆分法获得光学纯中间体8,通过优化α-β不饱和酰胺的还原方法提高关键中间体11收率。通过优化反应条件减少最后一步副产物的生成提高Ion-31a的产率。结果:用酶促拆分法代替结晶拆分法使中间体8的光学纯度和产率显著提高;中间体11经雷尼镍催化氢化和四氢铝锂两步还原产率明显提高,最后一步制备Ion-31a时通过减少副产物提高其产率。结论:通过建立新的合成路线提高了中间体8和11的产率,结合优化后的反应条件将抗肿瘤转移先导化合物Ion-31a的合成工艺进行了优化,其收率大幅提高。     

Ionone和megastigmane译名商榷

通过查阅大量国内外文献,认为ionone和megastigmane的译名并不规范,缺乏其合理性,即并没有发现紫罗兰属（Matthiola R. Brown）植物中含ionone类化合物的报道,而在堇菜属（Viola L.）植物中分离得到ionone类化合物,其母核结构也需重新定名。对ionone和megastigmane的译名做了详细的分析与论述,最终建议将ionone译作香堇酮,megastigmane译作大柱香波龙烷,以期为植物成分中文名称的规范化提供参考。     

信宜润楠中的苷类成分

通过大孔吸附树脂、正相硅胶、Sephadex LH-20柱色谱,以及反相闪式柱色谱和HPLC等多种分离方法相结合,从信宜润楠95%乙醇提物中首次分离得到10个苷类化合物;借助红外、质谱和核磁共振等波谱学分析方法分别鉴定为淫羊藿次苷B1(1),boscialin-3-O-β-D-glucopyranoside(2),pisumionoside(3),异落叶松脂素9’-O-β-D-吡喃木糖苷(4),5’-甲氧基异落叶松脂素9’-O-β-D-吡喃木糖苷(5),南烛木树脂酚9’-O-β-D-吡喃木糖苷(6),(E)-4-羟基苯丙-7-烯4-O-β-D-吡喃葡萄糖苷(7),(E)-4-羟基-3-甲氧基苯丙-7-烯4-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(8)、4-羟基-3-甲氧基苯丙-8-烯4-O-β-D-吡喃木糖基-(1→6)-β-D-吡喃葡萄糖苷(9)和4-羟基-3,5-二甲氧基苯丙-8-烯4-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(10)。     

Ionone和megastigmane译名商榷

通过查阅大量国内外文献,认为ionone和megastigmane的译名并不规范,缺乏其合理性,即并没有发现紫罗兰属(Matthiola R.Brown)植物中含ionone类化合物的报道,而在堇菜属(Viola L.)植物中分离得到ionone类化合物,其母核结构也需重新定名。对ionone和megastigmane的译名做了详细的分析与论述,最终建议将ionone译作香堇酮,megastigmane译作大柱香波龙烷,以期为植物成分中文名称的规范化提供参考。     

檵木叶的化学成分研究

目的研究檵木叶的化学成分。方法药材采用丙酮提取,利用大孔树脂柱、ODS反相柱、硅胶柱、Sephadex LH-20等色谱技术进行提取分离,根据波谱数据对化合物进行结构鉴定。结果从檵木叶中分离得到11个化合物,分别鉴定为β-Dglucopranosyl(Z)-3-hexenol(1)、ampelopsisionoside(2)、红景天苷(3)、2-hydroxy-5-[3-hydroxybutyl]phenyl-β-D-glucopyranoside(4)、杨梅素-3-O-α-L-鼠李糖苷(5)、6″-O-galloylsalidroside(6)、绿原酸甲酯(7)、绿原酸(8)、杨梅素-3-O-β-D-葡萄糖苷(9)、alangionoside-A(10)、benzyl-α-L-rhamonopyranosyl-(1→6)-β-D-glucopyranoside(11)。结论化合物1~4、6、10、11为首次从该属植物中分离得到。