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利用CO2超临界流体技术从海南产的卫矛科植物巧茶Cathaexulis茎叶中分得4个木栓烷型三萜化合物,结构都通过波谱方法进行鉴定。 相似文献
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Hui-Yuan Gao Zheng-Hong Guo Peng Cheng Xiao-Min Xu Li-Jun Wu 《Journal of Asian natural products research》2013,15(10):834-842
Fractionation of the methanol extract from the roots of Salacia hainanensis Chun et How showing the potent inhibitory activity on α-glucosidase afforded two new lupane derivatives, 3α,28-dihydroxy-lup-20(29)-en-2-one (1) and 3α-hydroxy-lup-20(29)-en-2-one (2), a new friedelane derivative, D:A-friedo-oleanane-7α,30-dihydroxy-3-one (3), and a novel natural product, 2,3-seco-lup-20(29)-en-2,3-dioic acid (4), along with four known compounds (5–8). Their structures were established on the basis of spectral analysis, especially on the data afforded by 2D NMR and high-resolution mass spectra experiments. All of them showed a much stronger inhibiting activity on α-glucosidase than the positive control (acarbose, IC50 = 5.83 μM). Constituents with α-glucosidase inhibitory activity from this plant are reported for the first time. 相似文献
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de Andrade SF Comunello E Noldin VF Monache FD Cechinel Filho V Niero R 《Archives of pharmacal research》2008,31(1):41-46
The hexane, chloroform, ethyl acetate and aqueous-soluble fractions from leaves of Maytenus robusta (Celastraceae) were evaluated for their protective actions against ethanol-induced gastric lesions in rats. The treatment
with all fractions (150 mg/kg) and omeprazol (30 mg/kg) significantly reduced the lesion index, the total lesion area, and
the percentage of lesion, in comparison with the control group (p<0.05). Since the ethyl acetate-soluble fraction was found
to be most active in the pylorus ligated model, this fraction was further investigated and resulted in the isolation of triterpene
3,15-dioxo-21α-hydroxy friedelane. The triterpene was evaluated in the HCl/ethanol-induced ulcer model in mice. In this assay,
both the groups treated with 3,15-dioxo-21α-hydroxy friedelane and omeprazol, at a dose of 30 mg/kg, presented a significant
reduction in lesion index, total lesion area, and in the percentage of the lesion, when compared with the control group (p<0.05).
The result suggests that the antiulcer effect observed in the extract and fractions may be attributed, at least in part, to
this compound. Further experiments are underway to determine which antiulcer mechanisms involved in gastroprotection. 相似文献
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心脑血管疾病是我国成年人群首要致死病因,且发病率呈上升和年轻化趋势,运用中药治疗心脑血管疾病十分必要。天然产物是治疗心脑血管药物的重要来源。三萜类化合物是植物体内重要的次生代谢产物,具有广泛的生物活性,其中五环三萜类表现出明显的抗炎、抗肿瘤、抗病毒等药理作用。近年来,越来越多的研究集中在五环三萜类化合物抗心脑血管疾病领域,对其结构进行衍生化从而提升活性、改善药性的研究也越发深入。通过查阅国内外五环三萜类化合物及其衍生物近10年的文献专利报道,综述了齐墩果烷、乌苏烷、羽扇豆烷、木栓烷4种类型五环三萜类化合物及其衍生物抗心脑血管疾病的研究进展,为治疗心脑血管疾病药物的研发提供依据和参考。 相似文献
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