全文获取类型
收费全文 | 1328篇 |
免费 | 132篇 |
国内免费 | 94篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 11篇 |
妇产科学 | 8篇 |
基础医学 | 81篇 |
口腔科学 | 15篇 |
临床医学 | 68篇 |
内科学 | 57篇 |
皮肤病学 | 40篇 |
神经病学 | 28篇 |
特种医学 | 19篇 |
外科学 | 66篇 |
综合类 | 209篇 |
预防医学 | 41篇 |
眼科学 | 14篇 |
药学 | 626篇 |
中国医学 | 244篇 |
肿瘤学 | 23篇 |
出版年
2024年 | 7篇 |
2023年 | 31篇 |
2022年 | 54篇 |
2021年 | 55篇 |
2020年 | 38篇 |
2019年 | 34篇 |
2018年 | 42篇 |
2017年 | 35篇 |
2016年 | 40篇 |
2015年 | 48篇 |
2014年 | 96篇 |
2013年 | 97篇 |
2012年 | 97篇 |
2011年 | 106篇 |
2010年 | 57篇 |
2009年 | 61篇 |
2008年 | 73篇 |
2007年 | 87篇 |
2006年 | 78篇 |
2005年 | 54篇 |
2004年 | 48篇 |
2003年 | 44篇 |
2002年 | 33篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 17篇 |
1998年 | 13篇 |
1997年 | 12篇 |
1996年 | 11篇 |
1995年 | 18篇 |
1994年 | 8篇 |
1993年 | 12篇 |
1992年 | 15篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1973年 | 1篇 |
排序方式: 共有1554条查询结果,搜索用时 15 毫秒
1.
色甘酸钠混悬气雾剂与茶碱缓释胶囊治疗中度哮喘的比较 总被引:1,自引:1,他引:0
84例中度哮喘病人分成2组。色甘酸钠组(男性23例,女性20例,年龄26±s8a)吸入色甘酸钠混悬气雾剂10.5mg,tid。茶碱缓释胶囊组(男性22例,女性19例,年龄27±8a)口服0.25g。bid。2组均连续观察3mo。结果:色甘酸钠在减轻病人慢性症状、改善肺功能和降低气道高反应性等方面优于茶碱缓释胶囊,(P<0.01)。而后药仅可缓解近期症状。 相似文献
2.
Manis PB Molitor SC Wu H 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,153(4):443-451
During intracellular recordings in rodent brainstem slice preparations, dorsal cochlear nucleus (DCN) pyramidal cells (PCs) exhibit characteristic discharge patterns to depolarizing current injection that depend on the membrane potential from which the responses are evoked. When depolarized from hyperpolarized potentials, PCs can respond with a short-latency action potential followed by a long silent interval (pauser) or a train of action potentials with a long latency (buildup). During the silent intervals in a pauser or a buildup response, the membrane potential slowly depolarizes towards spike threshold, often exhibiting distinct voltage oscillations of 1–2 mV before the first spike. The subthreshold voltage oscillations were investigated using whole cell recordings from DCN PCs in rat pup (P10–14) brainstem slices. The oscillations were unaffected by excitatory and inhibitory neurotransmitter antagonists, and were not temporally locked to the onset of the depolarization. The oscillations typically became larger as spike threshold was approached, and had a characteristic frequency between 40 and 100 Hz. In the presence of tetrodotoxin (TTX, 500 nM), the oscillations were significantly suppressed, and could not be evoked at any voltage below or above spike threshold. The oscillations were not blocked by phenytoin or Cd2+, but they were affected by prior activity in the neuron for approximately 1 s. We conclude that voltage-gated Na+ channels are required to generate membrane oscillations during the buildup phase. We suggest that the subthreshold oscillations play a role in controlling spike timing in PCs when the membrane potential slowly approaches, or hovers near, spike threshold. 相似文献
3.
The IgG subclasses of immunoglobulin for intravenous injection (IVIg) were investigated after various different types of treatment.
The level of IgG2 was relatively low in preparations treated with pepsin, but by changing the clone producing anti-IgG2 antibody,
the level approached that of normal human serum. Though undetectable in sulfonated immunoglobulin preparations, IgG3 was detected
after reoxidation. When determining the IgG subclasses of IVIg, it must be kept in mind that the apparent value may subsequently
become lower due to the depressed reaction of the antibody. 相似文献
4.
Chekhonin VP Lebedev SV Dmitrieva TB Blinov DV Lazarenko IP Savchenko EA Volodin NN 《Bulletin of experimental biology and medicine》2002,133(6):609-613
Cell preparations of ventral mesencephalon obtained from 8-, 14-, and 16-17-day rat embryos were stereotactically transplanted to homologous rats with 6-hydroxydopamine-induced hemiparkinsonism. Automated analysis of apomorphine-induced motor asymmetry for 3 months after neurotransplantation revealed higher efficacy of cell preparations from 8- and lower from 16-17-day-old embryos. These data correlated with histomorphological findigs, in particular, with the size of grafts, glial reaction, and the number of dopaminergic neurons in the grafts. 相似文献
5.
R. Kurth I. Schmidt A. Werner G. von Wangenheim J. Löwer H. -D. Brede 《Journal of molecular medicine (Berlin, Germany)》1986,64(8):386-388
Summary Samples of 96 polyvalent and virus-specific immunoglobulin batches commercially available in West-Germany were tested by enzyme-linked immunoassay and immunoblot for the presence of anti-HTLV-III antibodies. 37% of the polyvalent and 87% of the virus-specific batches were positive. It was concluded that these preparations are still safe and because of their reportedly low titer neutralizing antibodies possibly beneficial in certain cases, such as newborns of HTLV-III positive mothers or after accidental exposure to infectious material in clinics or laboratories.Abbreviations AIDS
acquired immunodeficiency syndrome
- ARC
AIDS-related complex
- CMV
cytomegalovirus
- ELISA
enzyme-linked immuno adsorbent assay
- HTLV-III
human T-cell lymphotropic virus, type III 相似文献
6.
Puttemans ML Dryon L Massart DL 《Journal of pharmaceutical and biomedical analysis》1985,3(6):503-510
Synthetic dyes were extracted from syrups, oral suspensions, tablets, gelatin capsules, suppositories and granules by ion-pair formation with tri-n-octylamine (TnOA) and back-extracted with perchlorate ions. Identification was performed by TLC on cellulose layers and by reversed phase ion-pair HPLC. 相似文献
7.
Alberti MB Pinzauti S Moneti G Agati G Giannellini V Coran SA Vincieri FF 《Journal of pharmaceutical and biomedical analysis》1984,2(3-4):409-415
The medicinally important quaternary ammonium salts benzyldimethyltetradecylammonium chloride (BDTA), cetylpyridinium chloride and benzethonium chloride, all afford, under fast atom bombardment (FAB) mass spectrometric conditions, abundant and persistent [M---Cl]+ species usefully amenable to quantitative analysis with the aid of thioglycerol as a liquid FAB matrix. The use of BDTA as an internal standard allowed a direct, precise and accurate determination of cetylpyridinium and benzethonium chlorides, either as pure samples or in dosage forms, in the concentration range 0.05–2 mg/ml. 相似文献
8.
目的:观察银黄洗剂治疗下肢血栓性浅静脉炎的临床疗效。方法:将62例诊断为下肢血栓性浅静脉炎的患者随机分为对照组和观察组,各31例。对照组在常规治疗的基础上应用硫酸镁湿敷,观察组在常规治疗的基础上应用银黄洗剂湿敷,疗程均为10 d。比较两组患者临床症状评分(皮肤颜色、患肢肿胀、硬索结节及疼痛的评分)、相关实验室指标(超敏C反应蛋白及纤维蛋白原)的变化情况以及总有效率。结果:观察组总有效率90.32%,高于对照组的64.52%(P<0.05)。与治疗前比较,两组症状体征评分明显改善,超敏C反应蛋白及纤维蛋白原明显降低(P<0.05)。观察组在改善症状体征及降低炎性反应方面较对照组更明显(P<0.05),两组治疗后纤维蛋白原数值比较,差异无统计学意义(P>0.05)。结论:银黄洗剂治疗下肢血栓性浅静脉炎,可有效改善患者临床症状及降低炎性反应,明显提高临床疗效。 相似文献
9.
盐酸氨溴索缓释胶囊的三维释放特性及其体内外相关性的 … 总被引:5,自引:0,他引:5
目的:评价自制盐酸氨溴索(Amb)缓释胶囊的体外质量,并研究人体内吸刷与体外释放的相关性。方法:采用转法考察转速对释放度的影响。常温留样和加速实验观察制剂稳定性,并进行PH时间的三维释放实验和健康人体内单剂量生物利用度实验,计算累积释药分数并根据Wagner-Nelson法计算体内药物吸收分数,经回归显示相关性。结果:Amb缓释胶囊释药受介质PH影响较小,且不受转速的影响。制剂贮存3个月,质量稳定 相似文献
10.
盐酸维拉帕米脉冲控释片人体内的药代动力学及生物利用度研究 总被引:1,自引:0,他引:1
目的:比较盐酸维拉帕米脉冲释放片与其片芯在人体的药代动力学特征及生物利用度。方法:采用拉丁方设计,将志愿者8人随机分为3组,交叉口服Ⅲ,Ⅳ型脉冲片和片芯,以片芯为对照制剂,考察体内脉冲控释效果。结果:Ⅲ型脉冲片在体内的时滞为4h,而cmax,AUC等与片芯无明显差异,达到设计要求。结论:该研究制备的脉冲释放制剂为防治心血管疾病的凌晨发作提供了一个良好的剂型选择。 相似文献