全文获取类型
收费全文 | 3169篇 |
免费 | 376篇 |
国内免费 | 232篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 20篇 |
妇产科学 | 15篇 |
基础医学 | 265篇 |
口腔科学 | 16篇 |
临床医学 | 69篇 |
内科学 | 183篇 |
皮肤病学 | 43篇 |
神经病学 | 54篇 |
特种医学 | 42篇 |
外科学 | 92篇 |
综合类 | 522篇 |
预防医学 | 47篇 |
眼科学 | 15篇 |
药学 | 1334篇 |
1篇 | |
中国医学 | 1027篇 |
肿瘤学 | 22篇 |
出版年
2024年 | 24篇 |
2023年 | 49篇 |
2022年 | 86篇 |
2021年 | 124篇 |
2020年 | 114篇 |
2019年 | 92篇 |
2018年 | 84篇 |
2017年 | 129篇 |
2016年 | 151篇 |
2015年 | 172篇 |
2014年 | 304篇 |
2013年 | 243篇 |
2012年 | 239篇 |
2011年 | 265篇 |
2010年 | 174篇 |
2009年 | 160篇 |
2008年 | 151篇 |
2007年 | 188篇 |
2006年 | 147篇 |
2005年 | 131篇 |
2004年 | 104篇 |
2003年 | 97篇 |
2002年 | 65篇 |
2001年 | 55篇 |
2000年 | 35篇 |
1999年 | 31篇 |
1998年 | 27篇 |
1997年 | 28篇 |
1996年 | 23篇 |
1995年 | 18篇 |
1994年 | 17篇 |
1993年 | 19篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 20篇 |
1987年 | 12篇 |
1986年 | 19篇 |
1985年 | 18篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 8篇 |
1981年 | 16篇 |
1980年 | 15篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 8篇 |
1970年 | 5篇 |
排序方式: 共有3777条查询结果,搜索用时 15 毫秒
1.
目的 探讨垂黄清脉冲剂对冠心病稳定型心绞痛(热毒痰瘀证)患者NF-κB信号通路的调控。方法 本试验研究方法采用单盲、随机、对照法,选取就诊于宁夏医科大学总医院临床诊断为冠心病稳定型心绞痛(热毒痰瘀证)患者94例,将其随机分入对照组48例和试验组46例。两组均给予内科常规西药治疗,对照组加服银丹心脑通软胶囊,试验组加服垂黄清脉冲剂,疗程为3个月。于治疗前、后记录患者的基本情况,并采集血清样本,用酶联免疫吸附测定法(Elisa法)检测血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1、NO浓度水平进行对比,用SPSS22.0将数据进行统计学分析。结果 与治疗前比较,两组治疗后Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平均较治疗前显著降低,NO浓度水平显著升高(P < 0.05,P < 0.01),其中试验组显著程度尤为明显(P < 0.01)。与治疗后对照组比较,试验组Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平降低,NO浓度水平升高趋势更明显(P < 0.01)。结论 垂黄清脉冲剂治疗冠心病稳定型心绞痛(热毒痰瘀证)在改善患者症状;改善冠状动脉管腔狭窄程度;通过降低炎症标志物TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1的水平,减小ET-1/NO比值,从而对NF-κB信号通路进行部分调控,以有效抑制或截断血管内皮的炎症级联反应过程,清除炎症损伤因素以及保护血管内皮功能等方面均有显著优势,临床疗效确切值得肯定和推广应用。 相似文献
2.
陈振华 《中国卫生标准管理》2020,(8):76-79
目的探讨儿童流感应用帕拉米韦注射液治疗的临床疗效以及用药安全性。方法随机选定在2016年1月-2019年1月期间佛山市高明区人民医院儿科住院治疗并确诊流感A或B型患儿200例,通过随机数字法将其分为治疗组和对照组。治疗组100例用帕拉米韦注射液治疗,对照组100例用国产磷酸奥司他韦颗粒治疗,评价两组患儿治疗前后症状评分、治疗效果、治疗指标以及不良反应发生情况。结果两组患儿治疗前流感样症状评分无统计学意义(P>0.05),两组患儿治疗后较治疗前流感样症状评分均下降,差异有统计学意义(P<0.05);治疗组治疗后流感样症状评分略小于对照组,但是无统计学意义(P>0.05);治疗组治疗总有效率高于对照组,治疗组患儿发热症状缓解、全部症状缓解以及住院时间均小于对照组,存在统计学意义(P<0.05)。治疗组与对照组不良反应发生率较低,且无统计学意义(P>0.05)。结论帕拉米韦注射液可用于儿童流感治疗,不仅能够保证临床疗效,而且可加快症状缓解,同时存在较高用药安全性。 相似文献
3.
In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samples. Two types of breast dense core granules can be distinguished on the basis of intracellular distribution patterns and histochemical reactivity. Type I dense core granules are the most common and they were found subluminally distributed in non-pathological tissues and benign lesions as well as carcinomas. They were uranaffin-negative and are unlikely to be of endocrine nature. Type II dense core granules were found only in four carcinomas, where they occurred abundantly throughout the cytoplasm. These granules were uranaffin-positive and argyrophilic and thus exhibited characteristics consistent with neuroendocrine structure. 相似文献
4.
大承气颗粒剂对胃肠动力影响的影像观察 总被引:2,自引:0,他引:2
目的 :探讨大承气颗粒剂对健康人群胃肠道动力的影响。 方法 :利用加入大承气颗粒剂钡餐造影技术 ,通过监视器、录像和摄片观察记录造影剂由胃排入十二指肠、十二指肠排入空肠、空肠排入空回肠、空回肠排入回肠、回肠排入回盲部的时间 ,结肠排出时间以及造影全过程总时间。受试者分三组各 3 0人。一组大承气颗粒剂组 (大承气组 ) ;二组为甘露醇组 ;三组为常规钡餐组。 结果 :大承气组除胃排入十二指肠、十二指肠排入空肠的时间与常规钡餐组比较无明显差别外 ,余各组小肠的排入时间、结肠排出时间以及造影全过程总时间与常规钡餐组比较P <0 0 5,与甘露醇组比较无明显差异。 结论 :大承气汤颗粒剂具有提高肠道张力、促进其推进作用 相似文献
5.
Actinomycetous infections typically involve either the head and neck or the extremities following a traumatic implantation.
Classic clinical associations are draining sinus tracts. This case report describes the pathologic and MR findings of a relatively
acute mycetomatous process involving the soft tissues. Pathologic findings in this case included an occasional granule composed
of gram positive, thin branching elements. These and other findings were consistent with actinomycetes bacterium infection.
The discussion centers around the use of MR, both with and without gadolinium, in evaluating this type of granulomatous infection.
Infiltration of the adjacent subcutaneous tissues was easier to appreciate on both the T1-weighted images without gadolinium
and the T1-weighted images with gadolinium when compared to the T2-weighted images. Signal characteristics as described in
this case report may suggest a granulomatous process. 相似文献
6.
7.
R. Magdeburg R. Grobholz G. Dornschneider S. Post D. Bussen 《Techniques in coloproctology》2007,11(4):372-374
Most cases of anal abscess are caused by anal fistula and invasion of the surrounding tissues by a mixed colonic flora. Treatment
consists of excision of the abscess and, in case of fistula, fistulectomy. Primary anorectal and perianal forms of actinomycosis
are very rare and caused by actinomyces, as ubiquitous anaerobics bacterium. We report a case of perianal actinomycosis. The
patient had a short history of painless perineal induration without fever and leukocytosis with normal results at routine
blood examination. After excision, sulfur granules drained from the cavity and pathological investigations indicated perianal
actinomycosis. Appropriate surgery and antibiotic treatment healed the perianal infection. After exclusion of possible diagnoses
such as Crohn’s disease, tuberculosis and malignant growths, the rare case of perianal actinomycosis should be considered
in the differential diagnosis of painless perianal masses. 相似文献
8.
宣肺清热颗粒剂稳定性研究 总被引:1,自引:0,他引:1
目的:研究宣肺清热颗粒剂中橙皮甙热稳定性变化,为该颗粒剂有效期的确定、制剂生产、贮存条什提供实验参考依据。方法:采用加速实验法对橙皮甙热稳定性进行研究,用甲醇超声提取样品,HPLC进行含量测定。根据Arrhenius公式处理数据。结果:Arrhenius公式得室温下的速度常数K298=3.38×10-5/h,得出常温下该颗粒剂以橙皮甙为指标的有效期为3.6年。结论:宣肺清热颗粒剂稳定性好,初步符合中药稳定性要求。 相似文献
9.
Tomoko Kamishima Takeaki Fukuda Toshio Kakihara Yoshihisa Ohnishi Makoto Naito Hidenori Ueki Shinzo Tachikawa 《Pathology international》1993,43(10):615-623
A case of small round and spindle cell sarcoma with neuronal differentiation and oncocyte-like features is presented. The tumor was encountered in a 32 year old Japanese woman with an initial presentation of palpable tumor in the left lateral region of the thorax. The resected tumor was a partially well encapsulated whitish medullary one and consisted of small round and spindle tumor cells, together with so-called rhabdoid cells in the small round cell area. Although pseudorosettes were often observed, true rosette formation could not be detected anywhere. Ultrastructurally, despite a histologic variety of tumor cells, most tumor cells possessed numerous mitochondria, some of which occasionally contained abnormal filamentous or crystalloid structures. Various amounts of microfilaments were present in most tumor cells and microtubules were present in a few. A minority of small round cells possessed a small number of neurosecretory granules, especially in short cytoplasmic processes. A positive immunoreaction for neuron specific enolase was found by immunohistochemical examination in several small round tumor cells and for neurofilaments in lesser numbers. Despite the lack of S-100 protein, MB2 was detected in both small round and spindle cells. On the basis of these findings, the tumor of the present case corresponds to malignant peripheral nerve sheath tumor with neuronal differentiation and oncocytic features. 相似文献
10.
W. J. Hofmann Herwart F. Otto W. Wöckel O. Thetter 《Virchows Archiv : an international journal of pathology》1995,425(6):641-646
A melanotic paraganglioma occurred in a 57-year-old woman, located in the left paravertebral space of the upper mediastinum. It was totally resected. During a 5 year follow up period neither tumour reccurrence nor metastasis were observed. Histological examination of the tumour revealed a paraganglioma with monomorphous chief cell like elements which were arranged in a zellballen pattern. Immunohistochemical results also were in accordance with the diagnosis since neuron-specific enolase, chromogranin and synaptophysin were found in tumour cells whereas keratin was not. Additionally, neurosecretory granules were found in tumour cells during electron microscopy. A peculiar feature of the tumour was its strong pigmentation due to melanin located within the tumour cells and tumour associated melanophages. The simultaneous expression of functional properties of two different neural crest derived cells in one tumour stresses the close relationship between all neural crest elements and is in accordance with the observation of other melanotic, non-melanomatous tumours.Dedicated to Prof. Dr. Dr. mult. h.c. W. Doerr on the occasion of his 80th birthday 相似文献