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Matrix metalloproteinase-1 expression inhibitory compound from the whole plants of Viola ibukiana Makino 总被引:1,自引:0,他引:1
Bioassay-guided fractionation has led to the isolation of two triterpenoid saponins 3-O-[O-beta-D-glucopyranosyl-(1 --> 3)-O-beta-D-glucopyranosyl] oleanolic acid (1), and 3-O-[O-beta-D-glucopyranosyl-(1 --> 2)-O-beta-D-glucopyranosyl] oleanolic acid (2) from the whole plants of Viola ibukiana Makino. Compound 2 showed matrix metalloproteinase-1 expression inhibition activities in a dose-dependent manner. 相似文献
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Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-omicron-[omicron-beta-D-glucopyranosyl-(1 --> 2)-omicron-beta-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time. 相似文献
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紫花地丁的化学成分 总被引:1,自引:0,他引:1
目的:对紫花地丁(Violayedoensis Makino)的化学成分进行研究。方法:采用色谱法进行化合物的分离纯化,通过波谱数据和理化性质鉴定化合物结构。结果:分离并鉴定出11个化合物,其中6个香豆素类:秦皮乙素(1)、东莨菪素(2)、菊苣苷(3)、早开堇菜苷(4)、秦皮甲素(5)、双七叶内酯(6);3个黄酮类:槲皮素-3-O-β-D-葡萄糖苷(7)、山柰酚-3-O-β-D-葡萄糖苷(8)、芹菜素(9);2个甾醇类:β-谷甾醇(10)、胡萝卜苷(11)。结论:秦皮甲素、胡萝卜苷为首次从堇菜属植物中分得;槲皮素-3-O-β-D-葡萄糖苷、山柰酚-3-O-β-D-葡萄糖苷、菊苣苷、早开堇菜苷、芹菜素均为首次从紫花地丁中分得。 相似文献
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