The Effectiveness of Using Interferon-gamma Release Assays in Screening Immigration Employees for Latent Tuberculosis Infection

Abstract

We assessed the prevalence of latent tuberculosis infection in immigration employees and compared two of the screening methods. Using a cross-sectional study design, we administered questionnaires regarding demographics, work, medical history, and tuberculosis risk factors to employees at two immigration facilities. Participants underwent tuberculin skin test (TST) placement and blood collection for the QuantiFERONTB Gold in-Tube (QFT-GIT) assay. Fifty-four employees underwent QFT-GIT and TST placement. All QFT-GIT results were negative, and three employees tested TST positive. Twenty-three (49%) of 47 employees requiring two-step TST testing underwent second TST placement. Return rates for first and second TST reading were 76% and 74%, respectively. The QFT-GIT completion rate was higher than that for TST (100% vs. 39%, P < 0.001). Agreement between TST and QFT-GIT was 94%. Immigration employees had low return rates for their TST reading and second TST placement. Performing the one-visit QFT-GIT has administrative and logistical advantages in this occupational group.     

生肌玉红膏促进结核性肛瘘创口愈合的临床疗效观察

目的：通过与凡士林纱的对比,观察生肌玉红膏对结核性肛瘘术后创口愈合的临床疗效。方法：将结核性肛瘘术后患者按单双日就诊时间分成两组,治疗组（30例）术后采用生肌玉红膏纱换药,对照组（30例）术后采用凡士林油纱换药,观察两组创面愈合情况。结果：治疗组创面渗液干净、肉芽组织出现、上皮组织出现、创面愈合、疼痛程度及时间各不同阶段的时间均优于对照组。统计结果显示,生肌玉红膏在减少创面渗液、增加愈合率、缩短愈合天数等方面的疗效均优于对照组。结论：生肌玉红膏对结核性痈瘘术后创面愈合具有促进作用。     

ENDOPHTHALMITIS INDUCED BY MYCOBACTERIUM TUBERCULOSIS BEING MISDIAGNOSED AS NON-INFECTIOUS UVEITIS

ENDOPHTHALMITIS induced by mycobacterium tuberculosis （TB） was rarely reported. Here we present and characterize this typical case to establish the diagnosis.     

隔蒜灸治疗难治性肺结核的临床观察

采用隔蒜灸治疗难治性肺结核患者８０例，经灸治后，患者临床症状、体征均有不同程度改善，有效率为６５％。同时机体细胞免疫功能低下状态得到纠正，表现为ＯＫＴ４（ＴＨ）细胞数量增高，ＯＫＴ４／ＯＫＴ８异常比值纠正，ＩＬ２及ＮＫ细胞活性增强。提示艾灸可能是通过增强Ｔ辅助细胞功能，促使ＩＬ２合成、释放增加，促进ＮＫ细胞活性以及调整ＴＨ／ＴＳ比值而起到治疗作用的。     

生肌玉红膏对结核性痈瘘术后创口愈合的促进作用

[目的]观察生肌玉红膏对结核性痈瘘术后创口愈合的临床治疗效果。[方法]将40例结核性痈瘘术后患者按单双日就诊时间分成两组,治疗组(20例)术后采用生肌玉红膏换药,对照组(20例)术后采用凡士林油膏换药,观察两组创面愈合情况。[结果]治疗组创面渗液干净、肉芽组织出现、上皮组织出现、创面愈合各不同阶段的时间均短于对照组(P<0.05)。术后21d,治疗组创面愈合率为70.0%,对照组为15.0%。统计结果显示,生肌玉红膏在减少创面渗液、增加愈合率、缩短愈合天数等方面的疗效均优于对照组(P<0.01)。[结论]生肌玉红膏对结核性痈瘘术后创面愈合具有促进作用。     

Tuberculosis in acute leukemia: A clinico-hematological profile

We studied 130 consecutive cases of acute leukemia over a 2-year period and identified 9 cases (6.9%) with active tuberculosis (TB). Eight patients with TB had acute myeloid leukemia (AML). Patients with AML were more likely to develop TB as compared to patients with acute lymphoblastic leukemia (ALL) despite the wider use of steroids and radiotherapy in ALL protocols {OR 4.41 (CI 0.53–36.44)}. Only 1 patient died of disseminated TB during post induction neutropenia. All other patients were successfully managed using current anti-tuberculous therapy (ATT). On the whole, TB did not cause any undue delay in chemotherapy and did not flare up during subsequent chemotherapy cycles. However it is not a commonly described infection in acute leukemia and a high index of suspicion is warranted especially in areas endemic for TB.     

早期前路病灶清除植骨融合内固定治疗胸腰椎骨结核

【目的】探讨早期前路病灶清除、减压、内固定及植骨融合对胸腰椎椎体骨结核的治疗效果。【方法】通过回顾性研究26例早期行前路病灶清除、减压、内固定的胸腰椎椎体骨结核患者恢复情况,以判断该治疗方法的临床疗效。【结果】经8个月至5年4个月的随访发现,26例病人的脊椎骨结核均治愈无复发,内固定牢固,植骨融合良好,神经功能恢复及保持良好。其中6例伴不全瘫患者神经功能全部恢复。【结论】早期前路病灶清除、彻底减压、有效内固定及植骨融合能及时解除或预防脊髓压迫,重建脊柱稳定,防止病灶扩散,有利于病情康复。     

骨关节结核患者外周血T细胞亚群的研究

采用SOKT系列抗人T淋巴细胞单克隆抗体,以直接SPA菌体花环法对19例骨关节结核患者外周血T细胞及亚群的分布进行了研究。结果表明,患者组SOKT_~ 细胞略有降低(P>0.05)、SOKT_4~ 细胞明显降低(P相似文献