除痹方治疗中晚期类风湿性关节炎的临床观察

本文运用中医辨证施治的理论 ,在总结多年临床实践经验的基础上 ,针对中、晚期类风湿病的阳虚寒凝、痰瘀互结和阴虚热郁、痰瘀互结两个不同的基本证型 ,自拟除痹温经汤和除痹清络汤。临床治疗中、晚期类风湿病 74例 ,治疗组 44例 ,治愈 5例 ,显效 19例 ,有效 16例 ,无效 4例 ,愈显率为 5 4.5 4% ,总有效率为 90 .91% ;对照组 30例 ,治愈 2例 ,显效 7例 ,有效 13例 ,无效 8例 ,愈显率 30 .0 % ,总有效率 73.33%。治疗组与对照组相比较有非常显著性差异 (P<0 .0 1)     

Development of constructed phrases in a child with language impairment

The emerging use of constructed utterances by a pre-school boy who initially used single words and routine phrases is described during a 7-month period, from 4;8-5;3. Emerging constructed phrases were consistent with a mixture of gestalt and analytic acquisition strategies. Some constructed phrases were variations on earlier routine phrases, and others were combinations of words that did not appear in earlier routines. Discussion of the child's course of language development is related to the literature on typical language acquisition and a model of language development in individuals with autism.     

国产头孢克肟颗粒的溶出度比较

目的比较国内3个不同厂家生产的头孢克肟颗粒的溶出性能。方法分别采用水、0.1mol/L盐酸溶液、pH7.0磷酸盐缓冲液3种溶出介质,搅拌浆法,转速为50r/min对各头孢克肟颗粒进行溶出度测定。结果3个厂家的头孢克肟颗粒在不同溶出介质中溶出均较好,其中在pH7.0磷酸盐缓冲液介质中溶出效果最佳,在45min时累积溶出量分别为50.03mg、49.74mg、49.79mg。结论国内部分厂家生产的头孢克肟颗粒内在质量均较好,相互间无明显差异。     

基于三维图形化数据挖掘方法的四物汤类方配伍规律研究

目的:研究用于不同血瘀证证型的四物汤类方的配伍特点,从组方药物性味归经及功效等属性研究各类方之间的共同特征。方法:在本实验室开发的二维方剂图形化挖掘方法的基础上,进一步增加了药物的功效属性,分别以性味、归经、功效属性为坐标,将方剂信息表现在三维图形上。分别将用于各类血瘀证型的方剂转化为三维图形,并寻找各类血瘀证型方剂对图形中的共同节点,分析四物汤类方治疗血瘀证的用药特点。结果:通过适用于不同证型的各类方间的三维方剂图形比较,发现了部分四物汤类方治疗血虚血瘀证的部分共同特征。组方药味性味以辛、甘、温为多,大多归肝、心、脾经,功效以补血、活血、止痛为主。这类节点在各证型类方中均出现较多,平均每方出现0.5～1.5次。这些节点可代表四物汤类方治疗血瘀证的一般特点,与传统理论相符。结论:三维图形化数据挖掘方法具有直观、形象的特点,便于从复杂数据中发现规律,非常适用于类方数据挖掘研究。     

Similar compounds searching system by using the gene expression microarray database

Numbers of microarrays have been examined and several public and commercial databases have been developed. However, it is not easy to compare in-house microarray data with those in a database because of insufficient reproducibility due to differences in the experimental conditions. As one of the approach to use these databases, we developed the similar compounds searching system (SCSS) on a toxicogenomics database. The datasets of 55 compounds administered to rats in the Toxicogenomics Project (TGP) database in Japan were used in this study. Using the fold-change ranking method developed by Lamb et al. [Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.P., Subramanian, A., Ross, K.N., Reich, M., Hieronymus, H., Wei, G., Armstrong, S.A., Haggarty, S.J., Clemons, P.A., Wei, R., Carr, S.A., Lander, E.S., Golub, T.R., 2006. The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313, 1929-1935] and criteria called hit ratio, the system let us compare in-house microarray data and those in the database. In-house generated data for clofibrate, phenobarbital, and a proprietary compound were tested to evaluate the performance of the SCSS method. Phenobarbital and clofibrate, which were included in the TGP database, scored highest by the SCSS method. Other high scoring compounds had effects similar to either phenobarbital (a cytochrome P450s inducer) or clofibrate (a peroxisome proliferator). Some of high scoring compounds identified using the proprietary compound-administered rats have been known to cause similar toxicological changes in different species. Our results suggest that the SCSS method could be used in drug discovery and development. Moreover, this method may be a powerful tool to understand the mechanisms by which biological systems respond to various chemical compounds and may also predict adverse effects of new compounds.     

A Quantitative Visualization Study of Flow in a Scaled-up Model of a Centrifugal Blood Pump

Abstract: A quantitative flow visualization study of a scaled-up model of a centrifugal blood pump was performed. Since the size of the scaled-up model was three times as large as the original pump under development, and the kinematic viscosity of the saline solution used as the working fluid was approximately one-third that of the blood, we obtained a similar flow at one twenty-seventh the angular velocity of the original pump. The flow was visualized by seeding the saline solution with neutrally buoyant particles and by illuminating the model with a laser light sheet. Since the gap flow behind the impeller is important for thrombus formation, it was recorded by a high-speed video camera, and the velocity field was evaluated automatically by particle tracking velocimetry. It was shown that in the gap behind the impeller there existed a region where the velocity profile was almost flat which can be called a core region. The results indicated the effectiveness of the present visualization technique for centrifugal blood pumps.     

Quantitative Visualization of Flow Through a Centrifugal Blood Pump: Effect of Washout Holes

Abstract: To clarify the effect of washout holes on the flow in a centrifugal blood pump to prevent blood stagnation, a quantitative flow visualization technique was applied to compare flows in models with and without washout holes. A scaled-up model of a prototype pump and a high speed video camera were used for the flow visualization, and images were processed by particle tracking ve-locimetry. Particular attention was paid to the flow through the gaps behind and in front of the impeller. The results showed that in the gap behind the impeller, washout holes caused not only an inward flow, but also an increase in the tangential velocities. In the gap in front of the impeller, washout holes caused an outward flow and a decrease in the tangential velocities. Head flow characteristics were little affected by the washout holes in this initial design for which the flow through the washout holes was set to be approximately 10% of the flow in the external circuit. These results suggest that the flow through washout holes is significant in the prevention of blood stagnation in 2 ways. First, the inward radial velocity behind the impeller and outward velocity in front of the impeller result in fluid exchange, and second, a tangential velocity increase reduces fluid stagnation behind the impeller.     

设计经编机中共轭凸轮廓线的解析法

本文探讨了设计经编机中共轭凸轮廓线的解析法,由于应用复数法导得了机构类角速度和类角加速度的简单表达式,并为凸轮理论廓线上任意点曲率半径以及凸轮实际廓线建立了二个新的方程式,具有一定的理论意义和实用价值。     

6厂家多潘立酮片的溶出度考察

目的：考察不同药厂生产的多潘立酮片的体外溶出情况,为临床用药提供参考。方法：参照日本在“药品品质再评价”拟定流程中对溶出度试验条件的规定,分别考察不同药厂多潘立酮片在水、pH1．2人工胃液、pH4．0醋酸盐缓冲液、pH6．8磷酸盐缓冲液4种溶出介质中的体外溶出行为,同时和部颁标准中规定的多潘立酮片溶出方法进行比较。结果：各药厂生产的多潘立酮片在酸性介质中均溶出良好,在水和pH6．8磷酸盐缓冲液中6h溶出均低于60％。结论：同一批多潘立酮片在不同溶出介质中溶出差异很大;不同药厂多潘立酮片的质量有显著性差异,临床用药时应加以注意。     

氧化低密度脂蛋白致血管内皮损伤机制及中药复方防治的研究进展

低密度脂蛋白经氧化修饰后主要通过凝集素样氧化低密度脂蛋白受体-1导致管内皮细胞损伤,诱导黏附分子和炎症因子的合成与释放,加重血管炎症反应,诱导内皮细胞凋亡,进而导致动脉粥样硬化等心血管疾病。中药复方通过抑制低密度脂蛋白(LDL)氧化生成氧化低密度脂蛋白（OX-LDL）,防治血管内皮损伤,进而防治动脉粥样硬化的发生与发展。综述近年来有关OX-LDL损伤血管内皮细胞功能的机制,及具有抗OX-LDL损伤作用的、脑心通、冠心合剂、血脉脂康胶囊、通心络、六味地黄方,黄连解毒汤等中药复方的研究进展。