中西医结合治疗血管性痴呆症36例观察

目的：观察中西医结合治疗血管性痴呆（VD）的疗效。方法：治疗组36倒，用中西医结合治疗，对照组33倒用喜得镇加脑复康治疗，观察治疗3个月。观察治疗前后患者的中医症状变化，以及简易智力状态量表（MMSE）和日常生活能力量表（ADL）积分的改变。结果：治疗组中医症状积分、ADL积分降低，MMES积分增加。本组治疗前后比较有极显著差异（P〈0．01），治疗组与对照组比较也有显著性差异（P〈0．05）。结论：中西医结合治疗血管性痴呆（VD），能够促进学习记忆的恢复，改善临床症状，是治疗VD的有效方法。     

微创膝关节单髁置换中期临床疗效研究

目的前瞻性研究微创膝关节单髁置换术（UKR）治疗膝内侧室骨关节病的中期临床疗效。方法对自2006年1月～2008年6月采用OxfordphaseⅢ假体行微创（MIS）一UKR的56例患者（60膝）进行了中期临床疗效的分析,并从影像学、KSS评分、WOMAC评分以及VAS评分等方面进行疗效评价。结果平均随访时间（73．0±2．4）个月;所有患者无术后感染、血栓形成、活动半月板脱位等并发症;无一例翻修病例;无死亡病例;KSS临床和功能评分分别由术前平均（41．2±3．3）分和（52．1±4．6）分增至术后（94．8±4．1）分和（93．8±3．2）分;WOMAC评分由术前平均（46．7±3．6）分减少为术后（11．4±1．8）分;VAS评分由术前平均（7．39±1．25）分降为术后（1．72±0．36）分;各项指标手术前后比较均有统计学差异（P均〈0．05）。结论MIS—UKR中期临床疗效满意,是治疗膝关节内侧室骨关节病的一个良好的手术选择。     

早期乳酸清除率与ICU严重脓毒症和脓毒症休克患者预后相关性的研究

目的：探讨早期乳酸清除率与ICU严重脓毒症和脓毒症休克患者预后的相关性。方法：选择2009-01-2012-03入住我院内科ICU的231例严重脓毒症和脓毒症休克患者,按预后分为生存组（139例）和死亡组（92例）,比较2组患者早期不同时段血乳酸清除率及APACHE Ⅱ评分;比较严重脓毒症和脓毒症休克患者早期不同时段血乳酸清除率及APACHE Ⅱ评分;早期不同时段乳酸清除率与APACHE Ⅱ评分进行相关回归分析。结果：2组患者入院时血乳酸、入院后6h及12h乳酸清除率、入院后各时段APACHEⅡ评分比较,差异有显著的统计学意义（P〈0.05及〈0.01）,入院后24h、48h和72h乳酸清除率的差异无统计学意义（P〉0.05）;严重脓毒症和脓毒症休克患者入院后6h乳酸清除率的差异也有显著的统计学意义（P〈0.01）;入院后6h和12h乳酸清除率与同时段APACHEⅡ评分存在负性直线相关关系。结论：ICU严重脓毒症和脓毒症休克患者早期（入院后6h和12h）乳酸清除率对于判断其预后具有重要的临床意义。     

沙丁胺醇、布地奈德联合治疗支气管哮喘急性发作疗效观察

目的探讨治疗支气管哮喘急性发作的有效治疗方法。方法对2009年2月～2011年5月收治的63例支气管哮喘患儿在急性发作期应用沙丁胺醇、布地奈德联合治疗,并以同期64例单用沙丁胺醇治疗患儿作为对照。结果观察组经沙丁胺醇、布地奈德治疗后显效43例,有效17例,总有效率95.2%;对照组单用沙丁胺醇治疗后显效34例,有效17例,总有效率78.0%。两组总有效率比较有显著性意义（x^2=6.94,P〈0.01）。治疗期间观察组未见明显不良反应。结论沙丁胺醇、布地奈德联合治疗支气管哮喘急性发作效果好,值得临床推广。     

心脏瓣膜病手术患者Ⅰ期心脏康复训练及护理

入选2011年6月—2012年6月行心脏瓣膜手术47例患者,在常规护理的基础上增加Ⅰ期心脏康复治疗。采用美国心脏协会推荐的心脏康复7步法配合日常生活训练,同时给予系列健康教育。本组100%患者在术后24～48 h,能在床上做主动及被动四肢运动;95%患者术后5～6 d能进行椅上活动,尝试自行到洗手间解大、小便;91%患者术后8～10 d可到洗手间进行各种清洗,恢复日常生活活动。本组实施康复锻炼过程中,13例患者心脏康复运动从第5步跨到第7步;5例患者从第3步跨到第5步;2例患者于术后第10天急性心功能衰竭发作,病情稳定后,康复运动从第5步倒退到第3步,但都能完成全部康复步骤。没有1例出现急性心功能衰竭发作或伤口裂开、大出血等并发症。认为康复运动七步法能帮助患者尽快恢复身心健康,改善术后心脏功能;但在实施过程中,离不开护士的专业支持与监测,既要细心观察、灵活掌握训练方法,又要了解患者的心理,在保障安全的前提下,及时鼓励和帮助患者。     

Identifying synonymy between relational phrases using word embeddings

Many text mining applications in the biomedical domain benefit from automatic clustering of relational phrases into synonymous groups, since it alleviates the problem of spurious mismatches caused by the diversity of natural language expressions. Most of the previous work that has addressed this task of synonymy resolution uses similarity metrics between relational phrases based on textual strings or dependency paths, which, for the most part, ignore the context around the relations. To overcome this shortcoming, we employ a word embedding technique to encode relational phrases. We then apply the k-means algorithm on top of the distributional representations to cluster the phrases. Our experimental results show that this approach outperforms state-of-the-art statistical models including latent Dirichlet allocation and Markov logic networks.     

Perception of Chinese poem and its electrophysiological effects

A neural correlate for phrase boundary perception in language has recently been identified as a reliable and replicable brain effect. It is called the closure positive shift (CPS) and has an equivalent in the perception of music (music CPS). Nevertheless, either in language or in music, this component is elicited by phrase boundary embedded in sentence or melody. Poetry, as the interlude of language and music, is a special kind of discourse and promising material to explore prosodic boundary processing beyond sentence level. The aim of the present study was to investigate the cognitive processing of hierarchical prosodic boundaries in Chinese Tang poem using rhythm matching task. There are generally four hierarchical levels in each poem, including foot boundary, phonological phrase boundary, intonational phrase boundary, and couplet boundary. The electrophysiological results indicated that all the prosodic boundaries of different levels in poems could give rise to the CPS reflecting prosodic phrasing. Furthermore, as the prosodic hierarchical level became higher, the onset latency of the CPS got longer, suggesting the influence of retrospective processing of former information. With regard to the amplitude, we analyzed the CPS amplitude in every 100 ms time window. It was showed that phonological phrase boundary elicited higher CPS amplitude as compared to that evoked by couplet boundary in an earlier time window, whereas in a later time window both of them were lower than the CPS correlated to intonational phrase boundary. The present results further shape our understanding of the CPS component and its relation to the processes involved in prosodic phrasing.     

慢性支气管炎急性期痰菌分离及耐药性的检测

目的:了解慢性支气管炎急性发作的病原菌及耐药性。方法:对慢性支气管炎急性发作82例患者的痰菌培养和药敏结果进行分析。结果:革兰阴性杆菌51.6%,革兰阳性球菌21.0%,真菌27.4%。在革兰阴性菌中铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌为主要菌种,对亚胺培南均敏感,革兰阳性菌中以金黄色葡萄球菌、肺炎链球菌为主,未发现耐万古霉素的金黄色葡萄球菌,真菌感染率不断上升。结论:慢性支气管急性发作者多为真菌与耐药菌混合感染,死亡率高。     

艾滋病合并巨细胞病毒性视网膜炎的诊断与治疗

目的探讨艾滋病（AIDS）合并巨细胞病毒（CMV）性视网膜炎的临床特征及相应的治疗。方法回顾性分析211例（422眼）AIDS患者的临床资料,包括发病时间、视力、眼前节、眼底检查、荧光素眼底血管造影（FFA）及外周血CD4＋T淋巴细胞检测结果,其中47例（63眼）合并CMV性视网膜炎,确诊后均足量全身使用抗病毒药更昔洛韦、地塞米松、抗凝药及改善循环药物,根据病情行球后注射等。结果初诊时,发病1周内者治疗有效率100%;发病1～2周者治疗有效率93.8%;发病2周后～4周者治疗有效率86.7%;发病4周以上者治疗有效率66.7%。结论 CMV性视网膜炎患者早期诊断是治疗的关键,早期全身足量抗病毒（CMV）药物治疗是基础,球后注射是有效的治疗方法。     

中医四字格术语的特点及翻译探讨

四字格术语频繁出现于中医药文献中,是中医术语的重要组成部分。为此,探讨了四字格术语的汉语语法特点和术语间的逻辑关系,及其相应的翻译方法。