排序方式: 共有34条查询结果,搜索用时 15 毫秒
1.
健康Sprague-Dawley种妊娠大鼠102只,均于妊娠第4天~第20天仿Younoszai法制备胎儿宫内发育迟缓模型.随机分成对照组、模型组、氨基酸组、青心酮组和山莨菪碱组,各组按规定给药,观察有关指标.结果表明:模型组胎仔发育明显迟缓,血红蛋白和红细胞压积水平升高,血栓素B_2/6-酮基-PGF_(1α)(TXB_2/6-keto-PGF_(1α))比值明显高于对照组.以上指标在青心酮组和山莨菪碱组得到明显改善,收到一定疗效. 相似文献
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M. Lahrichi Pierrette Tarallo Y. Houpert G. Siest 《Clinica chimica acta; international journal of clinical chemistry》1977,79(2):479-487
We studied the influence of substrates and glycolysis inhibitors on the release of proteins and enzymes from human leukocytes. We show the relationship between metabolic level and percentage of enzyme release.Leukocyte kept alive in a nutrient-free bicarbonate medium liberate enzymes even though their metabolic state is satisfactory. The addition of glucose to the medium significantly decreases this phenomenon without affecting the energy level. Addition of glycolysis inhibitors increases it, reduces the energy level, and interferes with other metabolic pathways.The results are discussed and compared to those obtained by other authors using various cell models. 相似文献
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Jerrold S. Meyer 《Experimental neurology》1983,82(2):432-446
Rats were adrenalectomized (ADX) or sham-operated (SHAM) on the 11th day of life and subsequent brain development (cerebrum and cerebellum) studied in terms of tissue weight and biochemical composition. Measured at about 65 days of age, early ADX subjects had significantly heavier brains (in terms of both wet and dry weights) than SHAMs, despite being lighter in overall body weight. Brain protein and DNA contents were elevated, as was the activity of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP), a myelin marker enzyme. Glycerol-3-phosphate dehydrogenase (GPDH), a glucocorticoid-regulated enzyme, was reduced in activity. Although both the cerebrum and cerebellum showed the growth-enhancing effects of early adrenalectomy, the DNA and CNP changes were most pronounced in the cerebrum. Finally, the effect of adrenal removal on myelinogenesis was confirmed by subcellular fractionation experiments demonstrating that more myelin could be recovered from the brains of ADX than from SHAM animals. These results are significant in terms of the influence of adrenal secretions on normal brain development and the role of GPDH in myelin lipid biosynthesis. 相似文献
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Mey UJ Olivieri A Orlopp KS Rabe C Strehl JW Gorschlueter M Hensel M Flieger D Glasmacher AG Schmidt-Wolf IG 《Leukemia & lymphoma》2006,47(12):2558-2566
The addition of rituximab to chemotherapy in patients with diffuse large B-cell lymphoma (DLBCL) has been shown to improve outcome in first-line therapy. However, in patients with relapsed or refractory disease, the value of adding rituximab to salvage chemotherapy is less clearly defined. This study performed a matched-pair analysis of patients with relapsed or refractory DLBCL by comparing the combination of dexamethasone, high-dose cytarabine and cisplatin (DHAP) with rituximab to DHAP alone. Sixty-seven patients with relapsed or refractory DLBCL were collected from two prospective phase II trials from Germany and Italy. Twenty-three patient pairs treated with either DHAP in combination with rituximab or DHAP alone could be analysed after matching for important prognostic factors. The addition of rituximab to the DHAP regimen led to higher complete and similar overall remission rates. However, differences with regard to complete remission rates failed to reach statistical significance, thereby necessitating further evaluation of the role of combined immunochemotherapy in this patient population. 相似文献
5.
Cd20 Expression and Effects on Outcome of Relapsed/Refractory Diffuse Large B Cell Lymphoma after Treatment with Rituximab 下载免费PDF全文
Afshan Asghar RasheedAdeel SamadAhmed RaheemSamina Ismail HiraniMunira Shabbir- Moosajee 《Asian Pacific journal of cancer prevention》2018,19(2):331-335
Introduction: Down regulation of CD20 expression has been reported in diffuse large B cell lymphoma (DLBCL)).Therefore, it is important to determine whether chemotherapy with rituximab induces CD20 down regulation and effectssurvival. Objectives: To determine the incidence of down regulation of CD20 expression in relapsed DLBCL aftertreatment with rituximab and to compare outcomes and assess pattern of relapse between CD20 negative and CD20positive cases. Methodology: We retrospectively reviewed patients with relapsed DLBCL who received rituximab inthe first line setting at Aga Khan University Hospital between January 2007 and December 2014. Data were recordedon predesigned questionnaires, with variables including demographics, details regarding date of diagnosis and relapse,histology, staging, international prognostic index, treatment and outcomes at initial diagnosis and at relapse. The Chisquare test was applied to determine statistical significance between categorical variables. Survival curves were generatedby the Kaplan–Meier method. Results: A total of 54 patients with relapsed DLBCL were included in our study, 38 (70%) males and 16(30%) females. Some 23 (43%) patients were at stage IV at the time of diagnosis and 34 (63%) had Bsymptoms. The most frequent R-IPI at diagnosis was II in 24 (44%) patients. Only 6 (11%) did not show CD20 expressionon re-biopsy for relapsed/refractory disease, 2 with CD20 negative DLBCL responding to second line chemotherapy.A complete response after salvage chemotherapy was noted in 16 (29.6%) cases with relapsed/refractory DLBCL.Seven (13%) patients underwent an autologous bone marrow transplant as consolidation after second line treatment.Median overall survival was 18 months in CD20 positive vs. 13 months in CD20 negative patients. Conclusion: Thisstudy demonstrated that a small percentage of patients treated with rituximab lose their CD20 expression at the timeof relapse. However, it is unclear whether this is associated with an inferior outcome. 相似文献
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目的:研究青心酮(DHAP)联合St.ThomasⅡ停跳液对离体大鼠心脏缺血再灌注后心肌功能的影响。方法:以离体大鼠工作心脏模型,对比青心酮联合St.ThomasⅡ停跳液与单纯St.ThomasⅡ停跳液,心肌缺血再灌前后左室压(LVP)、左室舒张末期压(LVDEP)、左心室内压上升及下降最大速率(±dp/dt max)、主动脉压(AP)、冠脉流量(CF)、主动脉流量(AF)、每搏心输出量(SV)和测定冠脉流出液乳酸脱氢酶(LDH),心肌三磷酸腺苷(ATP)含量、超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)含量。结果:青心酮联合St.ThomasⅡ停跳液产生较好的心肌保护作用,明显促进心肌缺血再灌后心肌功能的恢复,增进心脏的收缩功能、心肌ATP含量和SOD活性的恢复,减少LDH的漏出。结论:青心酮联合St.ThomasⅡ停跳液对心脏模拟体外循环的缺血再灌损伤具有保护作用,该方法有临床应用价值。 相似文献
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Smardova L Engert A Haverkamp H Raemakers J Baars J Pfistner B Diehl V Josting A 《Leukemia & lymphoma》2005,46(7):1017-1022
High-dose chemotherapy followed by autologous stem cell transplantation can improve the outcome of relapsed and refractory Hodgkin's disease (HD) patients. The objective of the trial was to determine the mobilizing potential of the DHAP salvage regimen (dexamethasone, cytarabine, cisplatin) for the collection of peripheral blood stem cells (PBSC) in patients with relapsed HD. The target yield of harvesting CD34 + cells was ≥ 2 × 106/kg in order to support the subsequent myeloablative chemotherapy. Most of the 105 patients included were intensively pre-treated with different combination chemotherapy regimens prior to mobilization. The use of DHAP followed by granulocyte colony-stimulating factor (G-CSF; 10 μg/kg) resulted in the successful collection of adequate numbers of PBSC in 97.1% of patients (102 of 105) with a median harvest of CD34 + cells of 13 × 106/kg (range 2.6 - 85.1). More than 2.0 × 106 CD34 + cells/kg were achieved in 65 of 103 (63%) patients after 1 apheresis, the maximum number of aphereses for all patients was 3. It was found that the optimal time of PBSC harvest was at days 13 - 16 after initiating the mobilization regimen.
These results demonstrate that the salvage chemotherapy regimen, such as DHAP combined with G-CSF, can be successfully used to mobilize PBSC in HD patients. 相似文献
These results demonstrate that the salvage chemotherapy regimen, such as DHAP combined with G-CSF, can be successfully used to mobilize PBSC in HD patients. 相似文献
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目的为了观察DHAP方案治疗复发难治性非霍奇金淋巴瘤(non—Hodgkin’s lymphoma,NHL)的临床疗效和不良反应。方法选择复发难治性NHL患者16例,采用DHAP方案化疗:DDP 85mg/m^2,静脉滴入,d1;Ara—c2g/m^2,静脉滴注,d2,每1次/12h;DXM 40mg/d,静脉推注,d1~d4。21-28d为1周期,共完成2~6个周期。结果16例患者CR6例(37.5%),PR5例(31.2%),SD3例(18.8%),PD2例(12.5%),总有效率为68.7%(11/16)。主要毒副反应为血细胞下降和消化道反应,均可耐受。结论初步研究结果显示,DHAP方案是治疗复发难治性NHL的有效解救化疗方案,缓解率高,不良反应可以耐受,值得临床进一步观察。 相似文献
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Some aspects of the glucose metabolism were investigated in platelets of 11 healthy donors and 11 patients suffering from thrombocytosis due to myeloproliferative disorders. Out of all the glycolytic compounds measured in resting platelets, dihydroxyacetonephosphate and fructose 1,6 bisphosphate were significantly higher in cells of subjects with thrombocytosis. No difference was observed in the basic net flux of glucose through the hexose monophosphate shunt. Addition of arachidonic acid to platelets of patients with thrombocytosis had a very poor effect in stimulation of the hexose monophosphate shunt, whereas high values of activation were obtained in control platelets. Lactate production determined by collagen was found significantly higher in all patients. These data observed in platelets of patients could be explained by a decreased pool of metabolic adenine nucleotides. 相似文献