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Objective To evaluate the effects of transforming growth factor β1 (TGF β1) autocrine blockage on proliferation activity and drug sensitivity of osteosarcoma.Methods Northern blot, MTT determination, and 3H thymidine incorporation were used to investigate the effects of antisense TGF β1 gene on osteosarcoma.Results The proliferation of osteosarcoma cells transfected by antisense TGF β1 gene was suppressed markedly, and adriamycin sensitivity was significantly increased.Conclusion Blockage ofosteosarcoma cells TGF β1 autocrine loop inhibits cell proliferation and enhances chemotherapy sensitivity. 相似文献
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【目的】通过分析肾虚髓亏、瘀血阻滞型膝骨性关节炎(knee osteoarthritis,KOA)与关节镜下病理改变之间的相关性,为中医临床诊治提供客观量化指标;观察和评价膝关节镜技术治疗膝骨关节病的有效性。【方法】将收集到的59例(65膝)患者给予膝关节镜技术治疗,观察其关节镜下病理表现并记录,主要运用聚类分析的方法,计数关节镜镜下表现在不同证型中的向量值,与中医证型进行相关性分析;通过膝关节综合评分及手术前后临床表现好转情况量化表,评价膝关节镜技术治疗膝骨关节病的有效性。【结果】肾虚髓亏、瘀血阻滞型KOA在关节镜下表现差异明显;膝关节镜技术对早、中期KOA患者治疗效果良好。【结论】膝骨性关节炎中医证型与其关节镜下表现有内在密切的联系;膝关节镜技术对膝关节软骨的评价及治疗上具有一定优越性。 相似文献
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