排序方式: 共有13条查询结果,搜索用时 15 毫秒
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Wen-Ni He Jun-Gui Dai Li-Jun Wu De-An Guo 《Journal of Asian natural products research》2013,15(9):760-764
Asiatic acid is a major pentacyclic triterpene isolated from Centella asiatica. It shows a variety of bioactivities. In order to obtain its derivatives, potentially useful for detailed pharmacological studies, the substrate was subjected to incubations with selected micro-organisms. In this work, asiatic acid was converted into three new compounds: 2α,3β,23,30-tetrahydroxyurs-12-ene-28-oic acid (1), 2α,3β,22β,23-tetrahydroxyurs-12-ene-28-oic acid (2), and 2α,3β,22β,23,30-pentahydroxyurs-12-ene-28-oic acid (3) by the fungus Alternaria longipes AS 3.2875. The structures of the three metabolites were determined by 1D and 2D NMR spectral data. 相似文献
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Myrna Déciga‐Campos Myriam Arriaga‐Alba Rosa Ventura‐Martínez Berenice Aguilar‐Guadarrama María Yolanda Rios 《Drug development research》2012,73(3):130-137
Strategy, Management and Health Policy | ||||
Enabling Technology, Genomics, Proteomics | Preclinical Research | Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics | Clinical Development Phases I‐III Regulatory, Quality, Manufacturing | Postmarketing Phase IV |
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Dai-Lin Liu Ying Liu Feng Qiu Ying Gao Jing-Ze Zhang 《Journal of Asian natural products research》2013,15(2):160-167
Microbial transformation of oleanolic acid (1) was carried out. Six transformed products (2–7) from 1 by Alternaria longipes and three transformed products (8–10) from 1 by Penicillium adametzi were isolated. Their structures were elucidated as 2α,3α,19α-trihydroxy-ursolic acid-28-O-β-d-glucopyranoside (2), 2α,3β,19α-trihydroxy-ursolic acid-28-O-β-d-glucopyranoside (3), oleanolic acid 28-O-β-d-glucopyranosyl ester (4), oleanolic acid-3-O-β-d-glucopyranoside (5), 3-O-(β-d-glucopyranosyl)-oleanolic acid-28-O-β-d-glucopyranoside (6), 2α,3β,19a-trihydroxy-oleanolic acid-28-O-β-d-glucopyranoside (7), 21β-hydroxyl oleanolic acid-28-O-β-d-glucopyranoside (8), 21β-hydroxyl oleanolic acid (9), and 7α,21β-dihydroxyl oleanolic acid (10) based on the extensive NMR studies. Among them, 10 was a new compound and compounds 5 and 8–10 had stronger cytotoxic activities against Hela cell lines than the substrate. At the same time, it was reported for the first time in this paper that the skeletons of compounds 2 and 3 were changed from oleanane to uranane and seven glycosidation products were obtained by biotransformation. 相似文献
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目的:研究长柄异木患(Allophylulogipess)茎中的化学成分。方法:对长柄异木患茎甲醇提取物的乙酸乙酯部分进行色谱分离,根据光谱数据和理化性质确定各化合物的结构。结果:分离得到25个化合物,分别鉴定为:ycloart-24-ene-3β,26-diol(1),3-oxotrirucalla-7,24-dien-21-oicacid(2),zizyberenalicacid(3),蛇藤酸(4),ent-4(15)-eudesmene-1β,6a-diol(5),4(15)-eudesmene-1β,8a-diol(6),4(15)-eudesmene-1β,5a-diol(7),甲基埃斯特瑞(8),白桦脂醇(9),白桦脂醛(10),白桦脂酸(11),3β-hydroxy-5a,8a-epidioxyergosta-6,22-dien(12),3-oxo-19a-hydroxyurs-12-en-28-oicacid(13),熊果酸(14),东莨菪内酯(15),梣皮啶(16),黄花菜木脂素A(17),香草醛(18),松柏醛(19),2’,6’-dihydroxy-4’-methoxyacetophenone(20),p-(aminoalkyl)-benzoicacid(21),香草酸(22),1-O-p-coumaroylglucose(23),β-谷甾醇(24),poriferast-5-ene-3β,4β-diol(25)。结论:所有化合物均为首次从长柄异木患(Allophylulogipess)中分离得到。 相似文献
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长柄紫珠化学成分研究 总被引:1,自引:0,他引:1
目的 系统研究长柄紫珠Callicarpa longipes的化学成分,为先导化合物的发现及质量评价提供基础.方法 采用反相硅胶、Sephadex LH-20、Toyopearl HW-40等柱色谱技术,结合重结晶进行分离纯化,光谱及核磁共振技术结合化学反应鉴定结构.结果 分离并鉴定了12个化合物,分别为熊竹山姜素(1)、5,4'-二羟基-3,6,7-三甲氧基黄酮(2)、阿亚黄素(3)、槲皮素-3,3',4'-三甲醚(4)、5,7,3',4'-四羟基-3-甲氧基黄酮(5)、芹菜素(6)、槲皮素-3,3'-二甲醚(7)、芹菜素-6,8-二-C-β-D-葡萄糖苷(8)、山柰酚-7-O-β-D-葡萄糖苷(9)、白桦脂酸(10)、熊果酸(11)、β-谷甾醇(12).结论 12个化合物均为首次从该植物中分离得到,其中化合物1~9为黄酮类,化合物2~5、7~9为首次从紫珠属中分离得到. 相似文献
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杨艳 《中国实验方剂学杂志》2011,17(13)
目的:考察圆果化香树中没食子酸的最佳提取工艺。方法:超声波提取圆果化香树中的没食子酸,通过正交设计方法,以没食子酸含量为考察指标,优化没食子酸的提取工艺。结果:四因素中提取溶剂对试验结果影响最大,提取时间为次要因素,其次为提取温度和提取次数。结论:圆果化香树中没食子酸最佳提取工艺为提取溶剂为水,在40℃下提取60分钟,提取2次。 相似文献
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《Pharmaceutical biology》2013,51(2):195-200
Heliopsis longipes S.F. Blake (Asteraceae: Heliantheae) (chilcuague) is used in Mexican traditional medicine against parasites and to alleviate tooth and muscle pains. Its biocide effect has already been experimentally demonstrated; however, its analgesic action and its action on the nervous system (NS) have not been investigated yet. The objectives of this study were to evaluate the analgesic action of affinin and the H. longipes root ethanol extract, as well as their effects on the NS using an animal model. The ethanol extract was obtained by maceration, and affinin was purified from it through chromatographic techniques. Chemical and thermal analgesia were used to assess their analgesic proprieties. Irwin’s test was used to evaluate their stimulating or depressing effects. The ethanol extract and affinin displayed analgesic action similar to ketorolac and stimulating effect comparable to caffeine on the nervous system of adult mice. 相似文献