白藜芦醇对2型糖尿病患者血糖、血脂和血液流变学的影响

目的观察白藜芦醇对2型糖尿病患者血糖、血脂及血液流变学各指标的影响,评价其在2型糖尿病及其并发症防治中的意义。方法将96例2型糖尿病患者随机分为对照组和治疗组,2组均施以糖尿病健康教育,适量运动、合理控制饮食、戒烟限酒、控制血糖、保持心情愉悦等常规干预,在此基础上治疗组加服白藜芦醇,每日600 mg,连服3个月。分别于干预前及干预结束后次日检测2组患者血糖、血脂4项[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]和血液流变学指标(全血黏度低切、全血黏度高切、血浆黏度、全血还原黏度、纤维蛋白原)。结果治疗组患者干预后空腹血糖、餐后2 h血糖、糖化血红蛋白、TC、TG、LDL-C、HDL-C、全血黏度低切、全血黏度高切、血浆黏度、全血还原黏度、纤维蛋白原水平均较干预前明显改善(P均0.05),对照组患者干预后上述各指标均较干预前无明显改善(P均0.05);2组患者干预后上述各指标比较差异均有统计学意义(P均0.05)。结论白藜芦醇用于治疗2型糖尿病患者,可以显著改善血糖、血脂和血液流变学各指标,从而预防或延缓并发症的发生。     

硬外阻滞对老年人血液流变学的影响

目的：探讨硬膜外麻醉对老年病人血液流变学的影响。方法：选择ASAI-Ⅱ级。在硬膜外麻醉下进行手术治疗的老年病人(年龄在60岁以上)20例。于麻醉前、麻醉后30分钟采静脉血9ml。分别监测血液流变学各参数的变化。结果：麻醉前红细胞聚集指数高于正常,余参数在正常范围。麻醉后全血粘度。红细胞聚集指数。血小板聚集率均降低。结论：硬外阻滞能降低老年病人的血液粘度。改善微循环灌注,减少静脉血栓及脑梗塞的发生。     

蝮蛇抗栓酶治疗类风湿关节炎153例

目的：探讨蝮蛇抗栓酶治疗类风湿关节炎的疗效。方法：类风湿关节炎病人１５３例（男性４３例，女性１１０例，年龄５１±ｓ８ａ，病程５．２±２．０ａ）采用蝮蛇抗栓酶１．０Ｕ溶于０．９％氯化钠注射液２５０ｍＬ中静脉滴注ｑｄ，３ｗｋ为一个疗程，结果，经２例疗程治疗，近期控制３７例（２４．２％），显效４３例（２８．１％）有效６６例（４３．１％）无效７例（４．６％），总有效率９５．４％，在改善晨僵，消肿止痛及关节     

不同液体术前急性高容量血液稀释对深静脉血栓病人血液流变学的影响

Objective To investigate the effects of acute hypervolemic hemodilution (AHH) with different fluids on blood rheology in patients with deep vein (femoral and iliac) thrombosis. Methods Thirty ASA I or II patients aged 40-64 yr who had developed deep vein thrombosis in 48 h and were scheduled for embolectomy were randomly divided into 3 groups ( n = 10 each) ; group I normal saline (NS) ; group II 6 % HES 200/0.5 ( HES) ; group IE gelofusine (GEL). AHH was performed with normal saline, 6% HES or gelofusine infusion at 20 ml·kg-1 ·h-1 for 40 min. MAP, HR and SpO2 were monitored. Blood loss, volume of blood transfusion and fluid infused and urine output during operation were recorded. Anesthesia was induced with fentanyl 3-5 fig/kg, etomidate 0.15-0.30 mg/kg, propofol 1-2 mg/kg and succinylcholine 1-2 mg/kg and maintained with 2% isoflurane and propofol infusion at 5-8 mg·kg-1·h-1 and intermittent iv boluses of vecuronium. The patients were mechanically ventilated (VT 8 ml/kg, RR 12 bpm). PaO2 and PaCO2 were maintained within normal range. Venous blood samples were obtained before and after AHH for measurement of hematocrit (Hct), whole blood viscocity (WBV) at low or high shear rates, plasma viscosity, RBC aggregation and RBC deformation. RBC aggregation index and RBC deformation index were calculated. Results MAP and HR were stable in all patients. The amount of blood transfusion and fluid infused was significantly less in group HES and GEL than in group NS. The WBV at low or high shear rates in group HES and GEL, Hct in all 3 groups and RBC aggregation index in group HES were significantly decreased after AHH, but the RBC deformation index was significantly increased in group HES. Conclusion Colloid is better than crystalloid and HES is better than gelofusine in improving intraoperative hypercoagulability and sluggish blood flow.     

川芎嗪对急性脑梗死患者血液流变学的影响

目的：探讨川芎嗪对急性脑梗死患者血液流变学的影响。方法：将58例急性脑梗死患者随机分成两组，对照组采用基础治疗法，川芎嗪在基础治疗的同时加川芎嗪，观察两组治疗前后血液流变学指标的变化。结果：川芎嗪组治疗后高、低切变率下全血粘度、血浆粘度、红细胞变形指数及纤维蛋白原与治疗前比较有显著性差异（P＜0．05），其血液流变性改善程度明显优于对照组。结论：川芎嗪显著降低纤维蛋白原和血粘度，具有改善脑缺血，减轻临床症状的作用。     

西洛他唑治疗脑动脉硬化30例

本组30例均符合脑动脉硬化的诊断，均为男性，年龄65～80岁。临床症状为头晕、头痛、记忆力减退、失眠。人院时查血液流变学指标均有不同程度异常。所有患者人院后未接受肠溶阿斯匹林，潘生丁、肝素等影响凝血的药物治疗，给予西络他唑片lOOmg2次/d口服，15d后观察患者临床症状．头痛头晕消失，记忆力和睡眠明显改善，血液流变学检查全血粘度切变率示。     

应用电子计算机计算血液流变学的正常值及分析

为评价血流粘滞诸因素生理与病理的异常,对济南地区338例正常人血液流变学的各项指标进行了检测,统计了血液流变学各项指标的总平均及男女的平均值和正常范围,并计算了血液流变学各项指标间的相关系数。     

消化膏穴位敷贴治疗慢性盆腔炎301例

经明确诊断的本病患者301例,应用验方消化膏局部穴位敷贴治疗。近期痊愈81例,显效130例,好转71例,无效19例,总有效率为93.68％。追访一年,各临床症状和体征均有不同程度的消失和好转,甚至怀孕。在实验室观察方面,治疗后血液流变学指标红细胞电泳时间、血浆粘度值,与治疗前比较有明显差异,机体吞噬细胞的吞噬功能,与治疗前比较,有显著性差异,在B超观察和对微循环的影响等方面,与治疗前比较,也有不同程度的改善。