2000年中国总膳食样品中六六六和滴滴涕污染的溯源性分析

通过对 2 0 0 0年总膳食样品中有机氯农药残留分析 ,发现南方二区和北方一区水产类样品六六六高残留。由两个地区分省的聚类样品溯源分析 ,结果发现湖北省鳊鱼六六六含量为 4 0 0 6 0 μg kg ,为南方二区水产类六六六含量的 88 8% ,黑龙江省鲤鱼六六六含量为 6 30 96 μg kg,为北方一区水产类六六六含量的90 3% ,这是造成两个地区水产类六六六高残留的主要原因。由六六六异构体构成比例及GC MS的确证分析提示 ,两个地区的水产类样品受到林丹的污染。本研究表明我国某些地区存在违规使用林丹的现象。为保证我国居民膳食安全性 ,加强六六六和滴滴涕残留监测仍是我国食品安全领域的长期任务     

Effect of lindane on testicular antioxidant system and steroidogenic enzymes in adult rats

Aim: To find out the effect of lindane on testicular antioxidant system and testicular steroidogenesis in adult male rats. Methods: Adult male rats were orally administered with lindane at a dose of 5.0 mg/kg body weight per day for 30 days. Twenty-four hours after the last treatment the rats were killed using anesthetic ether. Testes, epididymis, seminal vesicles and ventral prostate were removed and weighed. A 10% testicular homogenate was prepared and centrifuged at 4℃. The supernatant was used for various biochemical estimations. Results: The body weight and the weights of testes, epididymis, seminal vesicles and ventral prostate were reduced in lindane-treated rats. There was a significant decline in the activities of antioxidant enzymes superoxide dismutase (SOD), catalase and glutathione reductase while an increase in hydrogen peroxide (H2O2) generation was observed. The specific activities of testicular steroidogenic enzymes 3β-hydroxysteroid dehydrogenase and 1713-hydroxysteroid dehydrogenase were decreased. The levels of DNA, RNA and protein were also decreased in lindane-treated rats. Conclusion: Lindane induces oxidative stress and decreases antioxidant enzymes in adult male rats.     

科技部“中医药古籍与方志的文献整理(福建)”课题督导会议在我校召开

正4月21日下午,科技部基础性工作项目"中医药古籍与方志的文献整理(2009-2014)"督导检查会议在我校召开。总项目负责人国家中医药管理局科技司司长曹洪欣,中国中医科学院中医药信息研究所研究员崔蒙等督导组一行6人,对我校承担的子项目"福建地方志文献中中医药文献的辑录与整理研究"实地检查,并听取汇报。国家中医药管理局科技司中医处处长王思     

Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum

目的：本研究旨在探讨Ｔｅｔ对林丹—一种通过细胞内游离钙（［Ｃａ２＋］ｉ）介导大脑ｃｆｏｓ基因表达的神经毒剂—诱导的大鼠大脑ｃｆｏｓ基因表达的影响．方法：Ｎｏｒｔｈｅｒｎ印迹杂交，斑点杂交技术及双波长薄层色谱扫描分析．结果：大鼠口服林丹３０ｍｇ·ｋｇ－１１小时后大脑ｃｆｏｓ基因表达明显增强至１４６ｍｍ２，而在口服林丹前３０ｍｉｎ分别口服Ｔｅｔ１，２及４ｍｇ·ｋｇ－１，大鼠大脑ｃｆｏｓ基因表达被明显抑制（分别为８６，４０和３９ｍｍ２），其抑制程度呈剂量依赖关系．结论：Ｔｅｔ抑制Ｃａ２＋激动剂类神经毒剂—林丹诱导的大鼠大脑ｃｆｏｓ基因转录水平的表达．     

夏季也要防宫寒

夏季爱美的女孩们酷爱凉爽,林丹就是其中一个。最近她总是肚子不舒服,月经也不是很准,一次中医把脉。医师说她宫寒。林丹很奇怪这么热的天．又不是寒冷的冬季,为什么会宫寒呢？     

Lindane Degradation and Effects on Soil Microbial Activity

The degradation of U-^14 C-lindane in two Egyptian soils was determined in a three-month laboratory incubation.Lindane mineralization was slow and limited in both soils.Evolutionof ^14CO2 increased with time but only reached 3.5 to 5.5% of the intial ^14C-concentration with in 90 days.At that time both soils contained about 88% of the applied radiocarbon;33% to 37% of the intial dose was unetractable and assumed bound to the soils.The methanol-ex-tractable ^14C primarily contained lindane with traces of minor metabolites.Radiorespirometry was used to evaluate the effect of lindane on soil microbial activity.Low concentrations of the insecticide initially suppressed ^14CO2 evolution from U^-14C-glucose and microbial activity was significantly inhibited by 10 mg lindang/kg soil.     

六六六和林丹的大鼠致畸研究

用Sprague-Dawley大鼠进行六六六和林丹致畸研究,于孕期d6-15口喂给药,最高剂量分别为100mg/kg和13mg/kg,结果表明六六六和林丹影响胎鼠的生长发育,有胚胎毒性作用,但无致畸作用。     

从林丹失手看“努力反常”

“超级丹”输球了!这是每一个中国羽毛球爱好者都不愿意看到的情况。在不久前结束的多哈亚运会羽毛球比赛中,尽管林丹在与陶菲克前两次相遇中都战胜了陶菲克,在心理上占据了很大优势,可是在男单决赛中,在关键的第二局拥有四个局点的情况下,林丹被陶菲克反超,失去了夺冠的机会。     

西泉眼水库及周围地区林丹环境污染调查

林丹为有机氯类农药，其化学名称为丙体1．2．3．4．5．6-六氯环乙烷。通常把含丙体六六六在90％以上者称为林丹。林丹为无色晶体，化学性质稳定，高温、日光、强酸均不能使其分解，一般在表层土壤中可存留10年，难溶于水，易溶于有机溶剂、植物油、动物脂肪中。由于林丹污染环境严重且不宜去除，因此自70年代发达国家就已禁止生产和使用。我国自80年代末已开始禁止和限制生产和使用林丹。