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??Objective    To discuss the influence of basic periodontal therapy on the level of IL-8?? IL-10 in serum and gingival crevicular fluid in patients who have chronic periodontitis complicated by coronary heart disease. Methods     A total of 65 cases of patients with chronic periodontitis complicated by coronary heart disease were selected and divided into two groups randomly??Group A of 35 patients who received the basic periodontal therapy and cardiac medical treatment??Group B of 30 patients who received cardiological treatment only. Then??select 25 patient who had developed chronic severe periodontitis with non-systematic disease to establish group C and give them the basic periodontal therapy only. Observe the changes of the IL-8??IL-10 levels in serum and gingival crevicular fluid and the periodontal infection indexes??BI??PD??. Results    The results showed that after three months of basic periodontal therapy the periodontal clinical indices of both group A and group C became better and the IL-8 level obviously reduced??while the IL-10 level obviously increased. There was no obvious difference between group A and group B in each examination index before the therapy. After three months??we found that the periodontal infection index??SBI PD??of group A was obviously better than group B. Compared to group B??the IL-8 level of group A obviously reduced??and the IL-10 level obviously increased. The difference was statistically significant??P < 0.05??. Conclusion    The basic periodontal therapy can effectively improve periodontal conditions of the patients with chronic periodontal diseases??and reduce the risk of breaking the normal cardiovascular function.     

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??Strong evidences exist to support that chronic periodontitis is closely related with systemic disease??the pathopoiesis is that endotoxin?? inflammatory mediators?? cytokines caused the disease through blood circulation. In the study of the causes of chronic kidney disease?? there are also inflammatory mediators?? cytokines and other pathogenic factors?? therefore?? there is same contact between chronic kidney disease and chronic periodontitis.     

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?? Chemokine stromal cell-derived factor-1??SDF-1??has characteristics of cell migration and is expected to be used in the field of oral tissue repair and regeneration. When the damage occurs in the body's tissues and organs??impaired cells secret and express SDF-1 and recruit bone marrow-derived stem cells or progenitor cells to the injured site??so as to promote the repair of damaged tissue by providing the new blood vessels and cells. This paper summarizes the effect of SDF-1 in oral tissue repair and the direction of future researches of the SDF-1.     

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??Abstract??Objective To make doctor perform operation accurately on patients with dentomaxillofacial deformity by preoperative simulation based on digital data which was collected by digital software. Methods Fifteen patients had previously undergone 3-dimensional computed tomography and the data from CT scan were input into digital software. We used the software to simulate operations preoperatively including fixing point??osteotomies and movements of jaw bones. The collected information from software was applied to actual operations. Results All the operations had been completed successfully without serious complication. The patients were satisfied with the effect of operation 6 months after operation??with a satisfaction rate of 93.3%. Conclusion The digital simulation technique is a precise method which provides practical and effective basis for establishing the preoperative planning of individual optimal surgical procedure for patients with dentomaxillofacial deformities in orthognathic surgery.     

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根管遗漏往往会引起残髓炎或根尖周病变。上颌第一磨牙近中颊根第二根管(second mesio-buccal canal,MB2)因其细小、弯曲、根管口较为隐蔽,在临床上常造成根管遗漏,继而导致根管治疗的失败。因此,如何定位和疏通MB2是临床治疗中的难点。现报道1例上颌第一磨牙MB2遗漏的再治疗,以期为临床治疗提供参考。1病例资料     

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??Objective    To evaluate the effect of the T4K appliance on the maxillofacical function and structure of children with Class ?? division 1 malocclusion during the growth period??and to provide thetheoretical and practical evidence for the clinical application. Methods    Totally 20 children with Class ?? division 1 malocclusion were clinically corrected with T4K appliance??20 cases with the same deformity who refused to receive any treatment were include as controls. The effect of T4K appliance was analyzed through cephalometric radiography. Results    After T4K treatment??the patients′ profiles were much improved. The findings indicated that SNB??L1-MP??S-Go and N-Me were increased significantly compared with those in the control group?? but ANB??U1-SN??overjet and overbite were reduced obviously??the differences being statically significant??P??0.05??. Conclusion    T4K appliance can lead to an improvement of facial profile through treatment for Class ?? division 1 malocclusion??however??part of the effect come from the natural growth and development. Therefore??when T4K applicance is used for early orthodontic freatment for children with Class?? divesion 1 malocclusion??the potential of natural growth and development should be taken into account in order to achieve more effective results while doing less.     

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??Objective??To measure and compare the discrepancy of Collum angle of incisors among different types of Angle malocclusion using CBCT??and to provide guidance for the prevention of alveolar bone fenestration and dehiscence in anterior region. Methods??The cases of malocclusion were chosen in the Xi'an Jiao Tong University Hospital of Stomatology from 2014 to 2016??and four types of malocclusion were obtained class ??30 cases????class ??1 ??29 cases????class ??2??27 cases????class ??30 cases????according to the clinical occlusion. Sagittal sections of right upper and lower incisors were obtained by three-dimensional CBCT images using Invivo 5 software?? and Auto CAD 2007 software was used to measure the angle formed by the long axis of crown and root??Collum angle????and then analyzing the differences among groups were analyzed by single factor variance and compared by Scheffe method. Results??There were significant differences in the size of Collum angle among different types of malocclusion??P??0.05??. The Collum angle of upper incisor in class ??2 was ??7.02 ± 1.83??°??which was significantly larger than that of other groups. The Collum angle of lower incisor in Class ??1 was??-2.25 ± 4.76??°??which meaned that the crown could be lip side compared to the root??and there was significant difference compared with the other groups. The Collum angle of the lower incisor in class ?? was??8.15 ± 2.50??°??which was also significantly larger than other groups. Conclusion??There are significant differences in the Collum angle of the upper and lower incisors among different types of malocclusion. The crown of upper incisor in Class ?? 2 and lower incisor in Class ?? can be lingual side to the root??and the crown of lower incisor in Class II1 can be lip side compared to the root??which should be taken into consideration when the incisor is pulled backward or inclined to lip to avoid the root cutting through bone cortex.     

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??Helicobacter pylori??Hp?? infection is most frequently acquired during childhood and spontaneous clearance is rare. Hp infection can change the gut microbiota and cause the disease. In recent years??the Hp eradication rate through traditional triple therapy is decreased due to the development of Hp resistant strain. Probiotic therapy can inhibit the activity of Hp and reduce the side effects of drugs??which is a promising way to prevent and control the Hp infection.