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重度磨耗患者髁道运动学初步评价 总被引:7,自引:0,他引:7
评价重度磨耗患者后方髁道运动学特征 ,探讨髁状突运动与牙合重建的关系。方法 :运用Pantronic髁状突运动描记系统和D5ADenar全调节式咬合架 ,对 15例中老年重度磨耗患者后方髁道决定因素对牙合运动的影响 ,以及对 5例已完成咬合重建的重度磨耗患者髁道运动学特征进行初步评价。结果 :15例重度磨耗患者平均髁间距离为 ( 60 .72± 4.40 )mm ,迅即侧移量 (ISS) 1.3 5mm (右 )和 1.2 4mm (左 ) ,渐进侧移量 (PSS)为14 .65°(右 )与 17.11°(左 ) ,前伸髁导斜度 (PRO)为 2 3 .45°(右 )与 2 6.85°(左 ) ,非工作侧髁道值 (ORB)为 2 6.5 0° ,前伸髁导斜度与非工作侧髁道之间极相关 ,存在较小的Fisher角。结论 :咬合重建主要影响侧移量和Pantronic重复运动指数 (PRI)的大小 ,反映出下颌侧方边缘运动限制所恢复的程度。但牙合重建对非工作侧髁道没有明显的影响 ,运动道的变化并不能预测治疗的效果。 相似文献
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Low‐income urban parents of color enrolled in a parent training study were interviewed to understand what motivated their participation and what led 30% of them to subsequently drop out. Most enrolled because they wanted to be better parents. Most dropped out because of time and schedule constraints. Retention was higher when parents' motivations for participation matched program goals. Program location and qualities of the recruiter were cited most often as important; financial compensation was cited least often as important. 相似文献
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Thierry Tiendrebeogo Eugne Messou Shino Arikawa Didier K Ekouevi Aristophane Tanon Vivian Kwaghe Eric Balestre Marcel Djimon Zannou Armel Poda Franois Dabis Antoine Jaquet Albert Minga Renaud Becquet IeDEA West Africa Collaboration 《Journal of the International AIDS Society》2021,24(5)
IntroductionSex differences have already been reported in sub‐Saharan Africa for attrition and immunological response after antiretroviral therapy (ART) initiation, but follow‐up was usually limited to the first two to three years after ART initiation. We evaluated sex differences on the same outcomes in the 10 years following ART initiation in West African adults.MethodsWe used cohort data of patients included in the IeDEA West Africa collaboration, who initiated ART between 2002 and 2014. We modelled no‐follow‐up and 10‐year attrition risks, and immunological response by sex using logistic regression analysis, survival analysis with random effect and linear mixed models respectively.ResultsA total of 71,283 patients (65.8% women) contributed to 310,007 person‐years of follow‐up in 16 clinics in eight West African countries. The cumulative attrition incidence at 10‐year after ART initiation reached 75% and 68% for men and women respectively. Being male was associated with an increased risk of no follow‐up after starting ART (5.1% vs. 4.0%, adjusted Odds Ratio: 1.25 [95% CI: 1.15 to 1.35]) and of 10‐year attrition throughout the 10‐year period following ART initiation: adjusted Hazard Ratios were 1.22 [95% CI: 1.17 to 1.27], 1.08 [95% CI: 1.04 to 1.12] and 1.04 [95% CI: 1.01 to 1.08] during year 1, years 2 to 4 and 5 to 10 respectively. A better immunological response was achieved by women than men: monthly CD4 gain was 30.2 and 28.3 cells/mL in the first four months and 2.6 and 1.9 cells/μL thereafter. Ultimately, women reached the average threshold of 500 CD4 cells/μL in their sixth year of follow‐up, whereas men failed to reach it even at the end of the 10‐year follow‐up period. The proportion of patients reaching the threshold was much higher in women than in men after 10 years since ART initiation (65% vs. 44%).ConclusionsIn West Africa, attrition is unacceptably high in both sexes. Men are more vulnerable than women on both attrition and immunological response to ART in the 10 years following ART initiation. Innovative tracing strategies that are sex‐adapted are needed for patients in care to monitor attrition, detect early high‐risk groups so that they can stay in care with a durably controlled infection. 相似文献
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Amanda A. Uliaszek Nadia Al-Dajani Laura Mills 《Journal of child & adolescent substance abuse》2019,28(1):1-7
The present study sought to examine predictors of attrition from residential treatment for adolescents with addictive behaviors. Using data from 137 adolescents and their families, latent variable models were constructed to examine three child/adolescent factors and three parenting factors as predictors of attrition. Findings indicated that emotional/social difficulties and parental involvement in treatment, as well as their interaction, had a direct effect on attrition. In addition, parenting in adolescence interacted with both substance/behavioral problems and early caregiver discipline to predict attrition. This study provided insight into the exacerbating effects of neglectful or absent parenting practices in the successful completion of adolescent substance use treatment. 相似文献
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Premature termination appears to be a consistent problem in psychotherapy, showing up across client, treatment, and therapist types. As psychotherapy researchers and practitioners, it is important that we gain a better understanding of this negative psychotherapy event and identify methods for reducing its occurrence. This article introduces a special section on premature termination in psychotherapy. In addition to briefly introducing the articles contained in the special section, this article offers suggestions for future research on the topic of premature termination. 相似文献
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Maj-Brit Nørregaard Kjær Martin Bruun Madsen Nick Meier Anders Granholm Morten Hylander Møller Ingrid Egerod Anders Perner 《Acta anaesthesiologica Scandinavica》2023,67(7):842-852
Background
Health-related quality of life (HRQoL) is frequently assessed in randomised clinical trials (RCTs) in the intensive care unit (ICU), but data are limited regarding the proportions of patients without responses or not surviving to HRQoL follow-up and the handling of this. We aimed to describe the extent and pattern of missing HRQoL data in intensive care trials and describe how these data and deaths were handled statistically.Methods
We conducted a systematic review and meta-analysis following a published protocol. We searched PubMed, EMBASE, CINAHL and Cochrane Library for RCTs involving adult ICU patients reporting HRQoL as an outcome and excluded RCTs unobtainable in full text. We performed risk of bias assessment independently and in duplicate.Results
We included 196 outcomes from 88 RCTs published in the years 2002–2022; the numbers of patients alive and eligible to respond HRQoL were reported in 76% of trials. At follow-up, median 27% (interquartile range 14%–39%) of patients had died, and median 20% (9%–38%) of survivors did not respond across outcomes. Analyses of 80% of outcomes were restricted to complete cases only. The handling of non-survivors in analyses were reported for 46% of outcomes, with 26% of all outcomes reported as including non-survivors (using the value zero or the worst possible score).Conclusion
For HRQoL outcomes in ICU trials, we found that mortality at time of follow-up was high and non-response among survivors frequent. The reporting and statistical handling of these issues were insufficient, which may have biased results. 相似文献9.
Nicola North PhD RN AFACHSM William Leung MSc Rochelle Lee MHSc 《Journal of advanced nursing》2014,70(8):1813-1824
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《Drug discovery today》2021,26(11):2489-2495
Spiralling research costs combined with urgent pressures from the Coronavirus 2019 (COVID-19) pandemic and the consequences of climate disruption are forcing changes in drug discovery. Increasing the predictive power of in vitro human assays and using them earlier in discovery would refocus resources on more successful research strategies and reduce animal studies. Increasing laboratory automation enables effective social distancing for researchers, while allowing integrated data capture from remote laboratory networks. Such disruptive changes would not only enable more cost-effective drug discovery, but could also reduce the overall carbon footprint of discovering new drugs. 相似文献