全文获取类型
收费全文 | 3313篇 |
免费 | 326篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 86篇 |
妇产科学 | 34篇 |
基础医学 | 278篇 |
口腔科学 | 127篇 |
临床医学 | 231篇 |
内科学 | 322篇 |
皮肤病学 | 765篇 |
神经病学 | 220篇 |
特种医学 | 37篇 |
外科学 | 252篇 |
综合类 | 208篇 |
现状与发展 | 1篇 |
预防医学 | 35篇 |
眼科学 | 259篇 |
药学 | 635篇 |
2篇 | |
中国医学 | 85篇 |
肿瘤学 | 69篇 |
出版年
2024年 | 3篇 |
2023年 | 61篇 |
2022年 | 46篇 |
2021年 | 117篇 |
2020年 | 151篇 |
2019年 | 154篇 |
2018年 | 140篇 |
2017年 | 124篇 |
2016年 | 156篇 |
2015年 | 115篇 |
2014年 | 135篇 |
2013年 | 361篇 |
2012年 | 136篇 |
2011年 | 137篇 |
2010年 | 123篇 |
2009年 | 138篇 |
2008年 | 133篇 |
2007年 | 114篇 |
2006年 | 127篇 |
2005年 | 110篇 |
2004年 | 105篇 |
2003年 | 110篇 |
2002年 | 92篇 |
2001年 | 91篇 |
2000年 | 64篇 |
1999年 | 69篇 |
1998年 | 52篇 |
1997年 | 53篇 |
1996年 | 41篇 |
1995年 | 47篇 |
1994年 | 51篇 |
1993年 | 33篇 |
1992年 | 49篇 |
1991年 | 24篇 |
1990年 | 32篇 |
1989年 | 33篇 |
1988年 | 21篇 |
1987年 | 17篇 |
1986年 | 15篇 |
1985年 | 29篇 |
1984年 | 13篇 |
1983年 | 15篇 |
1982年 | 14篇 |
1981年 | 5篇 |
1980年 | 18篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1976年 | 6篇 |
1975年 | 3篇 |
1974年 | 4篇 |
排序方式: 共有3704条查询结果,搜索用时 15 毫秒
1.
2.
Iacopo Chiodini Daniela Merlotti Alberto Falchetti 《Expert opinion on pharmacotherapy》2020,21(6):721-732
ABSTRACT
Introduction
Glucocorticoid (GC) induced osteoporosis (GIOP) is the most common form of secondary osteoporosis. It develops in a dose and time dependent manner, due to a rapid and transient increase in bone resorption, followed by the inhibition of bone formation. 相似文献3.
4.
5.
Prolidase deficiency is a rare autosomal recessive disorder characterized by cutaneous ulcers, facial dysmorphism, recurrent infections, and intellectual disability. We report a unique case of a 6‐year‐old boy with prolidase deficiency and Crohn's disease who presented with lower extremity ulcers. Cutaneous ulcers due to prolidase deficiency are historically resistant to treatment, and we report success with the novel use of topical tacrolimus. 相似文献
6.
P Rubegni S Poggiali P Sbano M Risulo M Fimiani 《Journal of the European Academy of Dermatology and Venereology》2006,20(1):84-87
Tacrolimus is a macrolide that inhibits T-cell activation. The most extensive experience with topical tacrolimus has been in treating atopic dermatitis but it has been used in various skin diseases, including Hailey-Hailey disease, with encouraging results. We report a case of extensive Darier's disease successfully treated with topical tacrolimus, after suspension of oral isotretrinoin due to major depression. 相似文献
7.
Shengsong Huang~ Minbin Yu~ Jie Lian~ Min Fan~ Changyu Qiu~ Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou China The Department of Ophthalmology The First Hospital of Quanzhou Fujian China 《眼科学报》2003,19(3):156-160
Purpose: To evaluate the feasibility, reliability and analgesia effect of topical anesthesia combined with subconjunctival anesthesia in anti-glaucomatous surgery.Methods: Two hundred and four cases (357 eyes) underwent anti-glaucomatous surgeries under topical anesthesia with 0.5% Alcaine eye drops combined with subconjunctival anesthesia with 2% Lidocaine. The analgesic effect was analysed with visual analogue pain scale.Results: Among all of 357 eyes, 62 eyes underwent peripheral iridectomy, 67 eyes underwent simple trabeculectomy, 167 eyes underwent compound brabeculectomy and 12 eyes nonpenetrating trabecular surgery. The effects of anesthesia were as follows: 304 eyes (85.2%) were painless (Grade Ⅰ), 50 eyes (14.0%) were slight painful (Grade Ⅱ), and 3 eyes (0.8%) were more painful (Grade Ⅲ) during surgery. And no severe complications were observed in all the cases during surgery and postoperatively. Amaurosis fugax was not observed in the glaucoma patients at the late stage with narrow vi 相似文献
8.
R.J.W. de Keizer 《International ophthalmology》1997,21(6):335-341
In a prospective study the results of a pterygium excision in 54 patients (57 eyes) who underwent a superficial free conjunctival
autograft (FCG) were compared to those of patients who were treated with postoperative90Sr-irradiation. In 51 cases the minimum
follow-up was six months, the maximum follow-up seven years. We divided the study up into a randomized part and an open part.
In the randomized part, surgery of a primary pterygium was performed in 25 eyes, of which 16 were treated with a FCG and compared
with 9 eyes with primary pterygium surgery and postoperative90Sr beta-irradiation. In the same period 16eyes were treated
because of a recurrent pterygium: 8 with FCG and 8 with90Sr-irradiation. In the open part of the study16 eyes with primary
pterygium were successively treated with FCG alone.
The results showed in the randomized, as well as in the open study on primary surgery with a minimum follow-up of six month,
one recurrence in each of the FCG-groups (2 out of 31 eyes =6.4%), and no recurrences in the 90Sr-group(0%). In the randomized
group of patients treated for a recurrent pterygium one recurrence developed in the FCG group (1 out of 8 eyes =12.5%) and
one in the 90Sr-group (1 out of 7 =14.6%). Analysis of other clinical parameters showed that postoperative treatment with
corticosteroids, nonsteroidal anti-inflammatory drugs, and artificial tears was necessary for a longer period in the FCG group
than in the90Sr-group.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
9.
Objective: To study the rapid effect of glucocorticoids (GCs) on NMDA receptor activity in hippocampal neurons in stress and to elucidate its underlying probable membrane mechanisms. Methods: Whole-cell patch-clamp recording was used to assess the effect of stress concentration corticosterone (B) on the responses of cultured hippocampal neurons to glutamate and NMDA (N-methy-D-asparatic acid). To make clear the target of B, intracellular dialysis of B(10μmol/L)through patch pipette and extracellular application of bovine serum albumin-conjugated corticosterone (B-BSA, 10μmol/L)were carried out to observe their influence on peak amplitude of NMDA-evoked current. Results: B had a rapid, reversible and inhibitory effect on peak amplitude of GLU-or NMDA-evoked current in cultured hippoeampal neurons. Furthermore, B-BSA had the inhibitory effect on INMDA as that of B, but intraeeUularly dialyzed B had no significant effect on INMDA. Conclusion: These results suggest that under the condition of stress, GCs may rapidly, negatively regulate excitatory synaptic receptors-glutamate receptors (GluRs), especially NMDA receptor (NMDAR) in central nervous system, which is mediated by rapid membrane mechanisms, but not by classical, genomic mechanisms. 相似文献
10.
A. Ian Smith Catherine A. Wallace Lain J. Clarke John W. Funder 《Journal of neuroendocrinology》1989,1(5):357-362
In the sheep, unlike many other species, a significant proportion (>25%) of immunoreactive β-endorphin in the anterior pituitary is post-translationally modified to opioid-inactive, α-N-acetylated forms. In a study to determine the precise molecular nature of α-N-acetylated β-endorphin immunoreactivity, we noted a striking difference in high-performance liquid chromatography profiles of anterior pituitary extracts between sheep killed on the farm, and age-, sex- and strain-matched slaughterhouse animals. These altered patterns of a-N-acetylated β-endorphin processing were reproduced in farm animals by chronic (≤ 4 days) treatment with the synthetic glucocorticoid dexamethasone; in contrast dexamethasone had no effect on a-N-acetylated β-endorphin processing in hypothalamo-pituitary disconnected sheep. These data suggest that (1) the change in processing is a stress response, mediated by prolonged glucocorticoid exposure, (2) this effect is central, rather than a direct effect on the pituitary, and (3) the relative abundance of various peptide sequences in slaughterhouse-derived material may not reflect their abundance under more physiological conditions. 相似文献