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4 workers developed hand and face dermatitis when exposed to a floor top coal. This contained a polyurethane arid a polyfunctional aziridine hardener and additives. The aziridine hardener was made by reacting propyleneimine with a polyfunctional acrylate, trimethylolpropane triacrylate (TMPTA). All 4 reacted to the hardener and to TMPTA, which is present in excess, 2 of them also reacted to pentacrythritol triacrylate (PETA), which can be used in the production of aziridine hardeners. TMPTA and PETA cross-react, and are known sensitizers in UV-hardening acrylates.
The present finding shows that well-known sensitizers can be found in hidden sources when used in a quite different chemical process. 相似文献
The present finding shows that well-known sensitizers can be found in hidden sources when used in a quite different chemical process. 相似文献
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地尔硫治疗冠心病心绞痛180例 总被引:1,自引:0,他引:1
用随机、双盲、交叉对照法,以戊四硝酯片作为对照药,评定盐酸地尔硫(艹卓)治疗冠心病心绞痛180例的疗效。显示用中等剂量、1个月的疗程,症状总有效率为94.9%,静息心电图总有效率为49.7%,心电图运动试验总有效率为52.2%.此外心率减慢、血压降低、心率收缩压二重乘积和左心室收缩时间间期改善,全血粘度和血小板聚集可能降低。而不良反应发生率不高。经配对X~2检验,其效果优于戊四硝酯片。 相似文献
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Jean C. Parker Frederick J. Di Carlo Ivan W.F. Davidson 《European journal of pharmacology》1975,31(1):29-37
Previous studies in man have shown pentaerythritol (PE) trinitrate, given either sublingually or orally, produces a prolonged hypotensive effect. The coronary vasodilator and systemic vasoddepressor activities of PE trinitrate and its metabolites, PE dinitrate, PE mononitrate and PE, were evaluated in dogs to determine whether the metabolites were active and contributory. Coronary vasodilator activity was estimated with a flow transducer placed on the left anterior descending artery, and reduction of arterial pressure was determined directly via the femoral artery. Quantitative comparisons were made from dose—response curves established for nitroglycerin (NG), PE nitrates, and other common organic nitrates after intrajugular administration. Increase of coronary blood flow and reduction of arterial pressure were proportionally related, and the proportionality was the same for all drugs. Relative to NG, the potency of PE trinitrate was about 20%, erythrityl tetranitrate 12%, and isosorbide dinitrate 3.5%. The ratios of vasodilator activity of PE trinitrate and its metabolites were: PE trinitrate 100; PE dinitrate 1.5; PE mononitrate 0.5; and PE 0. Tachyphylaxis was observed after close-order injections of NG or PE trinitrate. In addition, there was cross tolerance between NG and PE trinitrate and also between PE trinitrate and its less active metabolites. 相似文献
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A thermoplastic intumescent coating system (IC) based on poly(vinyl acetate) was modified by two forms of multiwalled carbon nanotubes (CNTs), i.e., by a nanofiller powder and its solid dispersions in pentaerythritol (PER-CNTs). It was revealed that only the PER-CNTs modifier allows us to obtain solvent-borne ICs with a relatively high CNTs concentration (1–3 wt. parts of CNTs/100 wt. parts of paint solids) and acceptable application viscosity. Thermal insulation time (TIT) and intumescent factor (IF) of the ICs on a steel substrate (a fire test according to a cellulosic fire curve), as well as morphology, chemical structure (by the FT-IR technique) and mechanical strength of the charred systems, were investigated. It was found that the CNTs powder decreases TIT and IF values while PER-occluded CNTs improve these parameters (e.g., +4.6 min and +102% vs. an unmodified sample, respectively). Compressive strength of the charred ICs was improved by the PER-CNTs modifier as well. 相似文献
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目的:比较盐酸地尔硫控释片(下简称地片)与戊四硝酯(下简称硝片)治疗老年冠心病心绞痛的疗效及对收缩时间间期(STI)的影响。方法:冠心病心绞痛病人45例(男性29例,女性16例;年龄64±s4a)以随机、双盲、交叉对照法分别先后采用地片30~90mg,po,tid,加外观似硝片的安慰剂(淀粉)1~3片,po,tid,共4wk,为治疗组;或以硝片10~30mg,po,tid,加外观似地片的安慰剂1~3片,po,tid,共4wk,为对照组。2组于4wk疗程结束时,各给2种安慰剂1wk,待体内药物排尽然后2组交叉服药4wk。结果:地片组与硝片组比较,心绞痛症状疗效分别为96%对42%(P<0.01);心电图疗效分别为44%对29%(P>0.05);治疗组有显著降低高血压病人的舒张压及PEP/LVET比值的作用。结论:地片对心绞痛症状疗效、对原有高血压和STI不正常者疗效优于硝片。 相似文献
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Allergic contact dermatitis from Granuflex hydrocolloid dressing 总被引:1,自引:1,他引:0
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目的 研究3,4-二-O-甲基-1,2,5,6-四硝酸甘露醇酯(3,4-di-O-methyl-1,2,5,6-D-mannitol tetranitrate,DMMTN)对冠状动脉结扎所致大鼠急性心肌缺血的保护作用及其作用机制。方法 以结扎左冠状动脉前降支方法建立大鼠急性心肌缺血模型,建立假手术组、心肌梗死模型组、鲁南欣康组、DMMTN低、中、高剂量(15,30,60 mg·kg-1)组,测定手术后不同时段心电图ST段和T段的抬高;并于手术3 h后硝基四氮唑蓝( NBT) 染色法测定心肌梗死面积;测定血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)、丙二醛(MDA)和超氧化物歧化酶(SOD)。结果 DMMTN能显著缩小心肌梗死面积,抑制术后心电图ST段和T段的抬高;能显著降低CK和LDH的活力,以及MDA的含量,同时能显著提高SOD的活力。结论 DMMTN对冠状动脉结扎所致大鼠急性心肌缺血具有显著的保护作用。 相似文献