冬虫夏草对小鼠红系造血机能的影响

用微量甲基纤维素培养方法探讨冬虫夏草结晶制剂(CS-Cr)对小鼠骨髓红系祖细胞(CFU-E和BFU-E)增殖的影响。实验结果表明,CS-Cr明显提高骨髓CFU-E和BFU-E产率、自杀率,并能对抗三尖杉酯碱对造血机能的损害。采用液体培养技术发现CS-Cr促进骨髓成纤维祖细胞(CFU-F)增殖,其产率变化与CFU-E和BFU-E产率变化一致。     

Le syndrome de Smith-Magenis

Smith-Magenis syndrome is caused by a 17p11.2 deletion. It associates mental retardation, facial dysmorphism and brachydactyly; aberrant behavior and major sleep problems are present in 70% of the cases. It is probably under-diagnosed because the facial abnormalities are mild and the behavioral problems with hyperactivity and self-injuries are dominant, leading to the diagnosis of psychiatric pathology. However these behavioral problems are sufficiently characterized to allow the diagnosis of the syndrome and look for a 17p11.2 microdeletion. Otorhinolaryngologic, ophtalmologic, cardiac and renal abnormalities can be associated and their evaluation is necessary. Smith-Magenis syndrome is considered as a contiguous gene syndrome. Genes have been mapped and isolated to the critical region, but their participation in the pathogenesis of the syndrome remains unclear.     

The androgen receptor for the radiation oncologist

Androgen deprivation therapy is widely used in combination with radiotherapy for the treatment of prostate cancer. The knowledge of the biology of the androgen axis could help the radiation oncologist to combine both modalities in an efficient way. Moreover, new drugs have recently been approved and their role in combination with radiation needs pre-clinical and clinical studies. This review summarized the main data on the biology of androgen receptor and the potential implications for the physician. Mechanisms of interactions between androgen deprivation therapy and radiotherapy are also presented and discussed.