小型中医经络检测仪的研制

在传统中医经络理论的基础上，结合先进的电子技术设备，设计了一种小型中医经络检测仪。此检测仪通过采集人体穴位经电流测试(给一定电流刺激)所反射出来的信息，经微控制器处理后，能够精确显示或打印出人体的健康状况。检测仪具有方便、快捷等优势，易推广普及。     

微针技术的研究进展

微针以微机电系统(m icroelectro-mechani-cal systems,MEMS)技术为基础,在近年来发展迅速。本文主要介绍微针的制备方法,插入皮肤的机制,微针给药的特点以及微针的应用,详细介绍了微针在经皮给药中的应用。由于微针给药可以避免胃肠道对药物的降解作用和肝脏的首过效应等口服给药的缺点,并可消除注射给药时引起的疼痛,随着其发展不断完善,微针给药将会有广阔的应用前景。     

感冒退热泡腾片的干法制粒工艺研究

目的 研究感冒退热泡腾片干法制粒的工艺条件.方法 考察压轮压力、压轮转速和浸膏粉含水量对颗粒得率和颗粒脆碎度的影响.结果 压轮压力、压轮转速和浸膏粉含水量对颗粒得率和颗粒脆碎度有显著性影响.结论 感冒退热泡腾片干法制粒工艺的研究为感冒退热泡腾片研究与生产提供技术参考.     

Lost in Translation (LiT)

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 (‘LiT1’), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but there were still some brilliant successes. In LiT3, the coverage of translational medicine expanded from molecular biology to drug budgets, with much greater emphasis on safety and official regulation. Compared with R&D expenditure, the number of breakthrough discoveries in LiT3 was disappointing, but monoclonal antibodies for immunity and inflammation brought in a new golden era and kinase inhibitors such as imatinib were breakthroughs in cancer. The pharmaceutical industry is trying to revive the LiT1 approach by using phenotypic assays and closer links with academia. LiT4 faces a data explosion generated by the genome project, GWAS, ENCODE and the ‘omics’ that is in danger of leaving LiT4 in a computerized cloud. Industrial laboratories are filled with masses of automated machinery while the scientists sit in a separate room viewing the results on their computers. Big Data will need Big Thinking in LiT4 but with so many unmet medical needs and so many new opportunities being revealed there are high hopes that the roller coaster will ride high again.     

双列球面滚子轴承力学分析及滚子受载计算方法

以球面滚子轴承为研究对象,运用切片法,综合考虑了滚子 滚道凸度以及轴承内圈倾斜角的影响,建立了滚子并排和滚子错排的球面滚子轴承滚子载荷的计算模型。数值计算了内圈倾斜角、径向游隙、滚子错排角、以及外载荷等参数对球面滚子轴承滚子载荷和轴承内圈径向位移量的影响。计算结果表明,在一定的外载荷作用下,轴承内圈倾斜角度与滚子最大载荷呈线性变化规律;错排滚子的球面滚子轴承最大滚子载荷比并排略小,内圈径向位移量也略小。     

Time Course of Acute Hip Adduction Range of Motion Changes Following Foam Rolling

BackgroundWith the increased popularity of foam rolling (FR), it is important to establish the exact manner in which the practice is useful.PurposeThe purpose of this study was to examine the impact of FR the iliotibial (IT) band on hip adduction range of motion (ROM) and the short-term time course of any ROM changes that may occur.MethodIn a within-subject design, 34 subjects (21 female, 13 male) (female mean age 24.67 ± 8.6 yrs, height 161.4 ± 9.8 cm, mass 67.3 ± 12.3 kg; male mean age 22 ± 2.5 yrs, height 170.2 ± 8.2 cm, mass 76.3 ± 21.9 kg) underwent a baseline Ober’s test to measure hip adduction ROM prior to the FR and control conditions. Subjects rolled the lateral portion of each thigh for 3 bouts of 20 seconds. A tempo of 3 seconds down and 3 seconds up the leg was maintained across FR bouts. A 5-minute walk served as the control condition. The Ober’s test was repeated at less than 1 minute, 3 minutes, 10 minutes, 15 minutes, and 20 minutes following the FR bouts and the control to assess changes in hip adduction ROM over time. A blinded clinician conducted the Ober’s test. A two-way analysis of variance was used to assess differences by condition and time.ResultsNo differences in hip adduction ROM were found at baseline between FR and CON within subjects (27.9 cm ± 7.5 vs. 27.7 cm ± 6.6, p > .05). Ober’s test ROM was significantly greater in FR compared to CON immediately post-treatment (24.2 cm ± 6.3 vs. 28.2 cm ± 6.3, p = .00, d = .59), and 3 minutes post (24.6 cm ± 7.6 vs. 28.3 cm ± 5.9, p = .00, d = .56). No differences were observed 10 minutes post, 15 minutes post, or 20 minutes post FR or CON (p > .05).DiscussionCompared to walking, FR the IT band significantly increased hip adduction ROM as measured by the Ober’s test. These increases appear to dissipate between 3 and 10 minutes post-FR.ConclusionAn acute bout of 3 sets of 20 seconds of FR may be effective for transiently increasing ROM. Whether these short-term increases have implications for chronic flexibility changes is unclear.Level of evidence2     

改装滚轮微针促进人增生性瘢痕皮肤对醋酸曲安奈德的吸收

目的考察改装滚轮微针在人增生性瘢痕皮肤中对醋酸曲安奈德的促透作用。方法采用亚甲蓝和H-E染色法观察不同针长的微针刺入人增生性瘢痕皮肤的形态;建立高效液相色谱法测定醋酸曲安奈德含量;采用洗脱法、匀浆法分别考察给药1、12h时增生性瘢痕皮肤醋酸曲安奈德在体吸收特性;采用经皮水分流失(TEWL)测量法、激光多普勒血流量法考察其皮肤刺激性。结果所优选的针长500μm滚轮微针能有效穿透角质层,形成的微孔分布相对均匀;微针处理1、12h后,分别有27.42%、60.64%药物吸收进入皮肤。给药12h,皮内注射醋酸曲安奈德皮肤中滞留药量较给药1h下降至45.98%,而微针、直接涂布醋酸曲安奈德乳膏分别增加到2.73、4.18倍,微针组皮肤中滞留药量是直接涂布乳膏组的3.56倍(P<0.05)。皮内注射12h皮肤药量分布并不均匀,均值为(4.83±5.51)μg,微针组均值为(0.93±0.14)μg,分布相对均匀。TEWL法显示微针处理与皮内注射的皮肤刺激性差异无统计学意义,但激光多普勒血流量法显示皮内注射的皮肤刺激性是微针处理的8.40倍。结论改装滚轮微针处理后涂布醋酸曲安奈德乳膏较皮内注射醋酸曲安奈德在人增生性瘢痕中吸收均匀、皮肤刺激性较小,但其瘢痕治疗效果尚有待进一步验证。     

The Wear on Roller Press Rollers Made of 20Cr4/1.7027 Steel under Conditions of Copper Concentrate Briquetting

This paper defines the wear process of rollers made of 20Cr4. Rollers with a diameter of 1000 mm were installed in a roller press used for the production of drop-shaped briquettes and the copper concentrate was briquetted for 1100 h. Three-dimensional (3D) geometry analysis, metallographic analysis, macroscopy, scanning electron microscopy, as well as hardness measurements were performed. It was observed that the working surface was non-uniformly worn. The smallest wear affects the molding cavities situated on the outermost edges of the ring. The wear increases as the center of the ring is approximated, and it reaches its maximum at the middle of the ring. The molding cavities also wear asymmetrically. For the shape considered in this study, the lower part of a cavity is subject to a higher wear rate. We found that the material of the working ring was carburized, but its hardness was significantly lower than required. The roller ring microstructure changes depended on the distance from the cavity’s face. An investigation of the wear mechanisms showed different types of abrasive wear, corrosive processes, and plastic deformation. The exact type and course of wear were described, depending on the location on the working surface.     

Design,Development, and Evaluation of a Novel Microneedle Array-based Continuous Glucose Monitor

The development of accurate, minimally invasive continuous glucose monitoring (CGM) devices has been the subject of much work by several groups, as it is believed that a less invasive and more user-friendly device will result in greater adoption of CGM by persons with insulin-dependent diabetes. This article presents the results of preliminary clinical studies in subjects with diabetes of a novel prototype microneedle-based continuous glucose monitor. In this device, an array of tiny hollow microneedles is applied into the epidermis from where glucose in interstitial fluid (ISF) is transported via passive diffusion to an amperometric glucose sensor external to the body. Comparison of 1396 paired device glucose measurements and fingerstick blood glucose readings for up to 72-hour wear in 10 diabetic subjects shows the device to be accurate and well tolerated by the subjects. Overall mean absolute relative difference (MARD) is 15% with 98.4% of paired points in the A+B region of the Clarke error grid. The prototype device has demonstrated clinically accurate glucose readings over 72 hours, the first time a microneedle-based device has achieved such performance.