Homogeneous deuteriodeiodination of iodinated tyrosine in angiotensin‐I using synthesized triethyl[2H]silane and Pd(0)

In our efforts to develop new reactions for the efficient labelling of peptides and proteins with tritium, we now report the use of silane hydrides together with homogenous Pd(0) catalysis for the protio‐ and deuteriodeiodination of an o‐iodo‐tyrosine containing peptide (angiotensin‐I) performed at room temperature. Copyright © 2010 John Wiley & Sons, Ltd.     

Electrochemical hydrodehalogenation of 2,4-dichlorophenol in paraffin oil and comparison with aqueous systems

Electrochemical hydrodehalogenation (HDH) of 2,4-dichlorophenol (DCP) has been carried out in paraffin oil solutions using a solid polymer electrolyte reactor in a batch recycle mode with a dilute H₂SO₄ aqueous solution as the anode feed and source of hydrogen. The technology expands the application ranges of the electrochemical HDH from aqueous systems to non-conductive media. The influence of current density, reactant concentration and temperature is evaluated. The data are compared with those achieved in aqueous solutions. The HDH, in the paraffin oil, has been demonstrated in operation periods of up to 170 h.