全文获取类型
收费全文 | 114972篇 |
免费 | 9680篇 |
国内免费 | 4823篇 |
专业分类
耳鼻咽喉 | 617篇 |
儿科学 | 2791篇 |
妇产科学 | 2020篇 |
基础医学 | 22606篇 |
口腔科学 | 2305篇 |
临床医学 | 8946篇 |
内科学 | 23108篇 |
皮肤病学 | 2172篇 |
神经病学 | 5261篇 |
特种医学 | 1817篇 |
外国民族医学 | 33篇 |
外科学 | 6697篇 |
综合类 | 14798篇 |
现状与发展 | 41篇 |
一般理论 | 12篇 |
预防医学 | 11031篇 |
眼科学 | 1620篇 |
药学 | 12900篇 |
39篇 | |
中国医学 | 2333篇 |
肿瘤学 | 8328篇 |
出版年
2024年 | 132篇 |
2023年 | 1481篇 |
2022年 | 3359篇 |
2021年 | 4630篇 |
2020年 | 3823篇 |
2019年 | 3564篇 |
2018年 | 3529篇 |
2017年 | 3631篇 |
2016年 | 3855篇 |
2015年 | 4341篇 |
2014年 | 6448篇 |
2013年 | 8414篇 |
2012年 | 6235篇 |
2011年 | 7217篇 |
2010年 | 5933篇 |
2009年 | 5622篇 |
2008年 | 5586篇 |
2007年 | 5731篇 |
2006年 | 5302篇 |
2005年 | 4753篇 |
2004年 | 4253篇 |
2003年 | 3711篇 |
2002年 | 3035篇 |
2001年 | 2769篇 |
2000年 | 2257篇 |
1999年 | 2023篇 |
1998年 | 1861篇 |
1997年 | 1843篇 |
1996年 | 1618篇 |
1995年 | 1568篇 |
1994年 | 1402篇 |
1993年 | 1212篇 |
1992年 | 983篇 |
1991年 | 912篇 |
1990年 | 769篇 |
1989年 | 680篇 |
1988年 | 632篇 |
1987年 | 458篇 |
1986年 | 422篇 |
1985年 | 737篇 |
1984年 | 569篇 |
1983年 | 399篇 |
1982年 | 430篇 |
1981年 | 341篇 |
1980年 | 260篇 |
1979年 | 185篇 |
1978年 | 181篇 |
1977年 | 112篇 |
1976年 | 105篇 |
1975年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
The circadian rhythm in humans is determined by the central clock located in the hypothalamus’s suprachiasmatic nucleus, and it synchronizes the peripheral clocks in other tissues. Circadian clock genes and clock-controlled genes exist in almost all cell types. They have an essential role in many physiological processes, including lipid metabolism in the liver, regulation of the immune system, and the severity of infections. In addition, circadian rhythm genes can stimulate the immune response of host cells to virus infection. Hepatitis B virus (HBV) infection is the leading cause of liver disease and liver cancer globally. HBV infection depends on the host cell, and hepatocyte circadian rhythm genes are associated with HBV replication, survival, and spread. The core circadian rhythm proteins, REV-ERB and brain and muscle ARNTL-like protein 1, have a crucial role in HBV replication in hepatocytes. In addition to influencing the virus’s life cycle, the circadian rhythm also affects the pharmacokinetics and efficacy of antiviral vaccines. Therefore, it is vital to apply antiviral therapy at the appropriate time of day to reduce toxicity and improve the effectiveness of antiviral treatment. For these reasons, understanding the role of the circadian rhythm in the regulation of HBV infection and host responses to the virus provides us with a new perspective of the interplay of the circadian rhythm and anti-HBV therapy. Therefore, this review emphasizes the importance of the circadian rhythm in HBV infection and the optimization of antiviral treatment based on the circadian rhythm-dependent immune response. 相似文献
5.
Collagens are the most abundant proteins in the extracellular matrix. They provide a framework to build organs and tissues and give structural support to make them resistant to mechanical load and forces. Several intra‐ and extracellular modifications are needed to make functional collagen molecules, intracellular post‐translational modifications of proline and lysine residues having key roles in this. In this article, we provide a review on the enzymes responsible for the proline and lysine modifications, that is collagen prolyl 4‐hydroxylases, 3‐hydroxylases and lysyl hydroxylases, and discuss their biological functions and involvement in diseases. 相似文献
6.
Hannah C. Nordhues Anjali Bhagra Natya N. Stroud Jennifer A. Vencill Carol L. Kuhle 《Mayo Clinic proceedings. Mayo Clinic》2021,96(7):1907-1920
The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less susceptible to severe illness. However, sex-disaggregated data are incomplete, leaving room for misinterpretation, and focusing only on biologic sex underestimates the gendered impact of the pandemic on women. This narrative review summarizes what is known about gender disparities during the COVID-19 pandemic and the economic, domestic, and health burdens along with overlapping vulnerabilities related to the pandemic. In addition, this review outlines recommended strategies that advocacy groups, community leaders, and policymakers should implement to mitigate the widening gender disparities related to COVID-19. 相似文献
7.
Her-Shyong Shiah Nai-Jung Chiang Chia-Chi Lin Chia-Jui Yen Hui-Jen Tsai Shang-Yin Wu Wu-Chou Su Kwang-Yu Chang Ching-Chiung Wang Jang-Yang Chang Li-Tzong Chen 《The oncologist》2021,26(4):e567-e579
Lessons Learned
- SCB01A is a novel microtubule inhibitor with vascular disrupting activity.
- This first‐in‐human study demonstrated SCB01A safety, pharmacokinetics, and preliminary antitumor activity.
- SCB01A is safe and well tolerated in patients with advanced solid malignancies with manageable neurotoxicity.
8.
9.
10.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease. Fluoxetine has been shown to increase hepatic lipid accumulation in vivo and in vitro. In addition, fluoxetine has been shown to alter the production of prostaglandins which have also been implicated in the development of non-alcoholic fatty liver disease. The goal of this study was to assess the effect of fluoxetine exposure on the prostaglandin biosynthetic pathway and lipid accumulation in a hepatic cell line (H4-II-E-C3 cells). Fluoxetine treatment increased mRNA expression of prostaglandin biosynthetic enzymes (Ptgs1, Ptgs2, and Ptgds), PPAR gamma (Pparg), and PPAR gamma downstream targets involved in fatty acid uptake (Cd36, Fatp2, and Fatp5) as well as production of 15-deoxy-Δ12,14PGJ2 a PPAR gamma ligand. The effects of fluoxetine to induce lipid accumulation were attenuated with a PTGS1 specific inhibitor (SC-560), whereas inhibition of PTGS2 had no effect. Moreover, SC-560 attenuated 15-deoxy-Δ12,14PGJ2 production and expression of PPAR gamma downstream target genes. Taken together these results suggest that fluoxetine-induced lipid abnormalities appear to be mediated via PTGS1 and its downstream product 15d-PGJ2 and suggest a novel therapeutic target to prevent some of the adverse effects of fluoxetine treatment. 相似文献