垂黄清脉冲剂干预治疗冠心病稳定型心绞痛热毒痰瘀证患者NF-κB信号通路的研究

目的 探讨垂黄清脉冲剂对冠心病稳定型心绞痛（热毒痰瘀证）患者NF-κB信号通路的调控。方法 本试验研究方法采用单盲、随机、对照法，选取就诊于宁夏医科大学总医院临床诊断为冠心病稳定型心绞痛（热毒痰瘀证）患者94例，将其随机分入对照组48例和试验组46例。两组均给予内科常规西药治疗，对照组加服银丹心脑通软胶囊，试验组加服垂黄清脉冲剂，疗程为3个月。于治疗前、后记录患者的基本情况，并采集血清样本，用酶联免疫吸附测定法（Elisa法）检测血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1、NO浓度水平进行对比，用SPSS22.0将数据进行统计学分析。结果 与治疗前比较，两组治疗后Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平均较治疗前显著降低，NO浓度水平显著升高（P < 0.05，P < 0.01），其中试验组显著程度尤为明显（P < 0.01）。与治疗后对照组比较，试验组Gensini积分、血清中TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1、ET-1浓度水平降低，NO浓度水平升高趋势更明显（P < 0.01）。结论 垂黄清脉冲剂治疗冠心病稳定型心绞痛（热毒痰瘀证）在改善患者症状；改善冠状动脉管腔狭窄程度；通过降低炎症标志物TNF-α、NF-κB、IL-6、ICAM-1、VCAM-1的水平，减小ET-1/NO比值，从而对NF-κB信号通路进行部分调控，以有效抑制或截断血管内皮的炎症级联反应过程，清除炎症损伤因素以及保护血管内皮功能等方面均有显著优势，临床疗效确切值得肯定和推广应用。     

帕拉米韦注射液治疗儿童流感的临床疗效分析

目的探讨儿童流感应用帕拉米韦注射液治疗的临床疗效以及用药安全性。方法随机选定在2016年1月-2019年1月期间佛山市高明区人民医院儿科住院治疗并确诊流感A或B型患儿200例,通过随机数字法将其分为治疗组和对照组。治疗组100例用帕拉米韦注射液治疗,对照组100例用国产磷酸奥司他韦颗粒治疗,评价两组患儿治疗前后症状评分、治疗效果、治疗指标以及不良反应发生情况。结果两组患儿治疗前流感样症状评分无统计学意义(P>0.05),两组患儿治疗后较治疗前流感样症状评分均下降,差异有统计学意义(P<0.05);治疗组治疗后流感样症状评分略小于对照组,但是无统计学意义(P>0.05);治疗组治疗总有效率高于对照组,治疗组患儿发热症状缓解、全部症状缓解以及住院时间均小于对照组,存在统计学意义(P<0.05)。治疗组与对照组不良反应发生率较低,且无统计学意义(P>0.05)。结论帕拉米韦注射液可用于儿童流感治疗,不仅能够保证临床疗效,而且可加快症状缓解,同时存在较高用药安全性。     

Treatment of iatrogenic biliary obstruction by balloon dilatation of a biliary jejunal fistula

Biliary obstruction and multiple hepatic abscesses occurred in a patient after ligation of a segmental branch of the right hepatic duct. The patient was successfully managed by transhepatic biliary drainage and balloon dilatation of an internal fistula that developed between the ligated duct and a Roux limb of jejunum. Internal biliary fistulas may be dilated using interventioanl radiologic techniques to permit nonobstructed bile flow. Implications for the nonsurgical treatment' of biliary strictures are discussed.     

The nature of breast dense core granules: uranaffin reactivity

In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samples. Two types of breast dense core granules can be distinguished on the basis of intracellular distribution patterns and histochemical reactivity. Type I dense core granules are the most common and they were found subluminally distributed in non-pathological tissues and benign lesions as well as carcinomas. They were uranaffin-negative and are unlikely to be of endocrine nature. Type II dense core granules were found only in four carcinomas, where they occurred abundantly throughout the cytoplasm. These granules were uranaffin-positive and argyrophilic and thus exhibited characteristics consistent with neuroendocrine structure.     

Initial healing in the dog of submerged versus non‐submerged porous‐coated endosseous dental implants

It has previously been reported that porous‐coated root form endosseous dental implants, became well integrated when used in the traditional 2‐stage surgical approach. In this study, the placement of the implant in a 1‐stage (non‐submerged)technique was to be explored. Implants were placed in the mandibles of dogs, and 2 designs were used differing only in that one (experimental) had a 3mm transgingival extension, permitting it to be exposed lo the oral cavity from the outset. 12 (3 per animal) non‐submerged implants were placed on I side of 4 beagle dogs and 12 control (submerged) implants were placed contralaterally. All implants were allowed to heal for 6 weeks, after which histological preparations were made. 2 of 12 non‐submerged implants were lost due to post‐operative complications: otherwise, all implants healed uneventfully. Histomorphometric analysis revealed bone‐implant contact, as assessed by absolute bone contact (ABC) and contact length fraction (CLF). to be greater for the submerged design, suggesting that bone healing may be delayed with the non‐submerged approach. As well. at this early stage of healing, for both implant designs, ABC and CLF were significantly greater on proximal than on buccal and lingual aspects.     

大承气颗粒剂对胃肠动力影响的影像观察

目的 :探讨大承气颗粒剂对健康人群胃肠道动力的影响。 方法 :利用加入大承气颗粒剂钡餐造影技术 ,通过监视器、录像和摄片观察记录造影剂由胃排入十二指肠、十二指肠排入空肠、空肠排入空回肠、空回肠排入回肠、回肠排入回盲部的时间 ,结肠排出时间以及造影全过程总时间。受试者分三组各 3 0人。一组大承气颗粒剂组 (大承气组 ) ;二组为甘露醇组 ;三组为常规钡餐组。 结果 :大承气组除胃排入十二指肠、十二指肠排入空肠的时间与常规钡餐组比较无明显差别外 ,余各组小肠的排入时间、结肠排出时间以及造影全过程总时间与常规钡餐组比较P <0 0 5,与甘露醇组比较无明显差异。 结论 :大承气汤颗粒剂具有提高肠道张力、促进其推进作用     

小儿纵隔肠源性囊肿影像学表现及分析

目的 分析小儿纵隔肠源性囊肿及其并发症的影像学表现及诊断。资料与方法 回顾性分析经手术病理证实的8例小儿纵隔肠源性、神经肠源性囊肿及其并发畸形、感染及出血时的影像学表现。结果 小儿纵隔肠源性囊肿多位于中后纵隔，呈圆形或椭圆形，密度均匀，边缘清楚。较大时可占据一侧胸腔的大部分。并发感染时囊肿壁模糊，囊内密度增高；囊肿穿孔后可与支气管相通，引起吸入性肺炎及咯血。神经肠源性囊肿均存在脊椎畸形。25％病例同时存在腹部肠重复畸形。结论 小儿纵隔肠源性囊肿少见，除囊肿本身的特点以外，还须注意其他伴发征象，诊断应依靠临床和综合影像学分析。     

Mycetoma of the calf

 Actinomycetous infections typically involve either the head and neck or the extremities following a traumatic implantation. Classic clinical associations are draining sinus tracts. This case report describes the pathologic and MR findings of a relatively acute mycetomatous process involving the soft tissues. Pathologic findings in this case included an occasional granule composed of gram positive, thin branching elements. These and other findings were consistent with actinomycetes bacterium infection. The discussion centers around the use of MR, both with and without gadolinium, in evaluating this type of granulomatous infection. Infiltration of the adjacent subcutaneous tissues was easier to appreciate on both the T1-weighted images without gadolinium and the T1-weighted images with gadolinium when compared to the T2-weighted images. Signal characteristics as described in this case report may suggest a granulomatous process.