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icv四肽Asn-Ala-Gly-Ala(NAGA)能引起大鼠痛阈持续升高,并呈剂量依赖关系(0.03—0.24μmol/rat)。这一作用可被纳洛酮(icv.0.26mg·kg~(-1))翻转。icv甲硫氨酸脑啡肽抗血清或亮氨酸脑啡肽抗血清,能抑制NAGA引起的镇痛作用;icv强啡肽A_(1-13)抗血清或β-内啡肽抗血清不影响NAGA引起的镇痛作用。结果提示NAGA的镇痛作用可能与大鼠脑内甲硫氨酸脑啡肽和亮氨酸脑啡肽的释放有关。 相似文献
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The recent detection of immunoreactive POMC derived peptides in the male reproductive tract raised the possibility that these hormones might regulate reproductive function. In addition, a variety of studies suggested that POMC derived peptides have paracrine effects in the testis. In this present study, after HCG addition to the organ culture medium, Sertoli cells cytoplasma became immunoreactive with the enkephalins antisera. 相似文献
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