全文获取类型
收费全文 | 19613篇 |
免费 | 1928篇 |
国内免费 | 1064篇 |
专业分类
耳鼻咽喉 | 124篇 |
儿科学 | 130篇 |
妇产科学 | 216篇 |
基础医学 | 1915篇 |
口腔科学 | 225篇 |
临床医学 | 1091篇 |
内科学 | 1864篇 |
皮肤病学 | 342篇 |
神经病学 | 600篇 |
特种医学 | 383篇 |
外国民族医学 | 2篇 |
外科学 | 683篇 |
综合类 | 3237篇 |
现状与发展 | 5篇 |
预防医学 | 850篇 |
眼科学 | 240篇 |
药学 | 7015篇 |
17篇 | |
中国医学 | 3062篇 |
肿瘤学 | 604篇 |
出版年
2024年 | 83篇 |
2023年 | 280篇 |
2022年 | 561篇 |
2021年 | 788篇 |
2020年 | 613篇 |
2019年 | 497篇 |
2018年 | 530篇 |
2017年 | 669篇 |
2016年 | 724篇 |
2015年 | 757篇 |
2014年 | 1448篇 |
2013年 | 1461篇 |
2012年 | 1519篇 |
2011年 | 1519篇 |
2010年 | 1224篇 |
2009年 | 989篇 |
2008年 | 1023篇 |
2007年 | 1081篇 |
2006年 | 941篇 |
2005年 | 842篇 |
2004年 | 680篇 |
2003年 | 573篇 |
2002年 | 504篇 |
2001年 | 434篇 |
2000年 | 377篇 |
1999年 | 321篇 |
1998年 | 265篇 |
1997年 | 198篇 |
1996年 | 207篇 |
1995年 | 206篇 |
1994年 | 185篇 |
1993年 | 112篇 |
1992年 | 121篇 |
1991年 | 114篇 |
1990年 | 86篇 |
1989年 | 100篇 |
1988年 | 82篇 |
1987年 | 77篇 |
1986年 | 70篇 |
1985年 | 85篇 |
1984年 | 59篇 |
1983年 | 52篇 |
1982年 | 43篇 |
1981年 | 28篇 |
1980年 | 21篇 |
1979年 | 19篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 4篇 |
1975年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
P. A. Hannan J. A. Khan A. Khan S. Safiullah 《Indian journal of pharmaceutical sciences》2016,78(1):2-7
Dosage form is a mean used for the delivery of drug to a living body. In order to get the desired effect the drug should be delivered to its site of action at such rate and concentration to achieve the maximum therapeutic effect and minimum adverse effect. Since oral route is still widely accepted route but having a common drawback of difficulty in swallowing of tablets and capsules. Therefore a lot of research has been done on novel drug delivery systems. This review is about oral dispersible tablets a novel approach in drug delivery systems that are now a day''s more focused in formulation world, and laid a new path that, helped the patients to build their compliance level with the therapy, also reduced the cost and ease the administration especially in case of pediatrics and geriatrics. Quick absorption, rapid onset of action and reduction in drug loss properties are the basic advantages of this dosage form. 相似文献
2.
《Drug discovery today》2022,27(6):1733-1742
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. Here, we review these assays and subject them to experimental optimization to improve their reliability. We demonstrate the usefulness of our assay cascade by assaying a library of bioactive compounds, chemical probes, and a set of approved drugs. These high-throughput assays should complement the array of wet-lab and in silico assays during the initial stages of hit discovery campaigns to pursue only hit compounds with tractable mechanisms of action. 相似文献
3.
《Anaesthesia and Intensive Care Medicine》2020,21(12):668-672
The invasive measurement of physiological pressures is a common requirement in anaesthesia and intensive care medicine. From arterial blood pressure to intracranial pressure, these calculated variables give a swift graphical and numerical representation of a patient's current physiological status. This allows us to respond rapidly to conditions outside our preferred parameters and to carefully titrate treatment to target effects. These systems are, however, not infallible. An understanding of the principles of their function will promote appropriate use and an ability to recognize and react to sources of error. This article aims to furnish the reader with this level of understanding in order to inform their academic and clinical practice. 相似文献
4.
目的:探讨美托洛尔(β1受体阻滞剂)用于老年COPD合并冠心病史治疗的临床疗效。方法:选取2018年6月—2019年6月在我院接受治疗的60岁以上(包括60岁)COPD合并冠心病史老年患者,分为对照组与观察组。对照组给予接受布地奈德福莫特罗粉吸入剂治疗,观察组在使用布地奈德福莫特罗粉吸入剂治疗的基础上口服琥珀酸美托洛尔缓释片治疗,观察对比两组治疗效果。结果:观察组临床治疗效果优于对照组,观察组住院时长以及并发症的发生率低于对照组(P<0.05),差异具有统计学意义。结论:老年COPD合并冠心病史接受美托洛尔治疗,可有效缩短住院时长、用药效果明显、有效提升用药安全性,值得临床推广。 相似文献
5.
Xin Mei Jiang Akio Ohnishi Tatsunori Yamamoto Yoshiyuki Murai Akira Awaya Masato Ikeda 《Acta neuropathologica》1995,90(2):130-134
One of the pyrimidine compounds, 2-piperadino-6-methyl-5-oxo-5,6-dihydro(7H)pyrrolo[3,4-d]pyrimidine (MS-818), has neurotropic effects in vitro. Therefore, we studied the effect of MS-818 on the regeneration of the peroneal nerve in C57BL/6J mice after a crush injury. Two test groups, which received a daily intraperitoneal injection of 5 mg/kg or 10 mg/kg MS-818, respectively, were compared with controls, which received daily intraperitoneal injections of physiological saline, over a 14-day period. The maximum foot-width ratio (crushed side/uncrushed side) was obtained on days 1, 8 and 14 after the crush injury, and the various morphometric parameters were evaluated at both 5 and 10 mm distal to the proximal portion of the crush site. The significant effects of MS-818 included a larger maximum foot width (P<0.04) and a greater number of unmyelinated axons per nerve at both levels (P<0.003) in both test groups than in controls. MS-818 had no significant effects on body weight, the increase of total transverse fascicular area after the crush injury, the total number of myelinated fibers with their size distributions, or the number of nuclei of Schwann cells and macrophages. Therefore, we conclude that MS-818 promotes axonal sprouting and elongation after a crush injury in mice. 相似文献
6.
7.
复方华蟾胶囊抗小鼠肿中瘤作用的实验研究 总被引:2,自引:0,他引:2
目的了解复方华蟾胶囊抗小鼠移植性肿瘤的作用.方法以小鼠肝癌22(H22)、小鼠肉瘤180(S180)为瘤株,应用动物移植性肿瘤的体内试验法对药物进行抗癌药效学试验.结果复方华蟾胶囊灌胃4,2 g/kg@d,连续14 d,对小鼠移植性肝癌实体型生长有明显的抑制作用,抑瘤率分别为38.09%,30.95%.对小鼠移植性S180实体型生长有明显的抑制作用,抑瘤率分别为34.7%,30.08%.复方华蟾胶囊对荷瘤小鼠的胸腺和脾脏重量无影响.结论复方华蟾胶囊在试验条件下有一定抗肿瘤作用. 相似文献
8.
Chronic intestinal pseudo-obstruction: manifestations, natural history and management 总被引:2,自引:0,他引:2
v. stanghellini r. f. cogliandro r. de giorgio g. barbara b. salvioli & r. corinaldesi 《Neurogastroenterology and motility》2007,19(6):440-452
Chronic intestinal pseudo-obstruction (CIPO) is a rare pathological condition characterized by a marked derangement of gut propulsive motility mimicking mechanical obstruction, in the absence of any lesion occluding the gut lumen. This disease is often associated with a disabling and potentially life-threatening complications and is still too often unrecognized even in referral centres. As a result, patients receive neither appropriate care nor recognition of their severe health condition. Medical and surgical therapies are often unsatisfactory and long-term outcome turns out to be poor in the vast majority of cases. This article focuses on the main clinical features, the management and long-term outcome of patients affected by CIPO, with particular emphasis on those aspects which remain a matter of debate. 相似文献
9.
目的探讨目前老年护理医院院内感染病原菌及其耐药特征。方法对2000年4月-2004年3月徐汇区两家老年护理院出院病人的病史进行统计分析。结果两家老年护理院共计发生医院感染939例次,医院感染率12.86%,检出病原菌284株,阳性率30.28%;病原菌以革兰阴性菌为主,占44.65%,其次为真菌、革兰阳性菌,分别为29.12%、25.92%,位于前3位的病原菌分别为其他真菌(14.36%)、白色念珠菌(12.23%)、铜绿假单胞菌(8.69%);除嗜麦芽寡养单胞菌外,革兰阴性菌以亚胺培南最敏感,敏感率87%,对氨苄西林、阿莫西林的耐药率〉51%,对头孢哌酮、哌拉西林的耐药率〉33%;MRSA和MRSE的检出率高达86.76%和76.32%;混合感染率34.51%。结论老年护理院医院感染率高.真菌所占的比例高;细菌对抗菌药物的耐药性相当严重。 相似文献
10.