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Bioactivity‐directed fractionation of the MeOH fraction of the extract of Mimulus bigelovii by means of an axenic Leishmania amastigote assay and chromatographic techniques resulted in the isolation of four C‐geranyl flavanones, diplacone (1), 3′‐O‐methyldiplacone (2), 4′‐O‐methyldiplacone (3), 3′‐O‐methyldiplacol (4), together with a geranylated flavone, cannflavin A (5). These compounds were separated from M. bigelovii for the first time. All compounds showed moderate antileishmanial activity against axenic Leishmania donovani amastigotes with IC50 values ranging from 4.8 to 14.6 μg/mL. The compounds were also tested against the related kinetoplastid parasite Trypanosoma brucei brucei and they showed activity with IC50 values ranging from 1.4 to 7.2 μg/mL. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
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海蓬子营养成分分析与急性毒性评价 总被引:1,自引:0,他引:1
目的分析种植于潮汕沿海海蓬子的营养成分,并对其安全性进行初步评价。方法采用常规生化分析方法。结果海蓬子嫩茎的含水量较低(90.99%),灰分(3.42%)、维生素C(40.66mg/100g)和β-胡萝卜素(1.74mg/100g)含量高,含有八种必需氨基酸,谷氨酸、精氨酸含量丰富、但缺乏含硫氨基酸,其他营养成分多数高于茎菜类蔬菜。种籽中蛋白质(34.01%)、油脂(23.79%)和维生素E(23.6mg/100g)含量都很高,其蛋白质质量较好。种油主要由亚油酸(70.62%),油酸(12.19%),棕榈酸(10.37%),亚麻酸(2.93%)等组成,有较高的营养和保健价值。小鼠急性毒性试验LD50464g/kg。结论海蓬子营养丰富,食用安全,有很好的开发利用前景。 相似文献
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