老鹳草鞣质类化合物的抗腹泻作用研究

对老鹳草总鞣质(HGT)的抗腹泻作用研究表明：HGT有较好的治疗腹泻作用，可减少番泻叶或蓖麻油所引起腹泻次数；并可显著抑制正常及推进功能亢进小鼠的墨水胃肠推进率。结果提示抑制胃肠推进运动是HGT止泻机理之一。     

苍苓止泻口服液治疗婴幼儿轮状病毒肠炎疗效观察

目的 :评价苍苓止泻口服液治疗婴幼儿轮状病毒肠炎的临床疗效。方法 :5 8例轮状病毒肠炎患儿随机分成苍苓止泻口服液治疗组和对照组。结果 :治疗组和对照组显效率分别为 34 48%、10 34 % ,两组比较有显著性差异 (P <0 0 5 ) ,治疗组在缩短病程和排毒时间等指标优于对照组 ,两组间有显著差异。结论 :苍苓止泻口服液治疗婴幼儿轮状病毒肠炎见效快 ,疗效肯定 ,不良反应少。     

无毒棉籽液抗腹泻作用机理

小鼠灌胃给予无毒棉籽３，６ｇ／ｋｇ对蓖麻油、硫酸钠致腹泻有拮抗作用，对正常小鼠及生大黄泻下鼠的肠腔水分无影响；对新斯的明、酚妥拉明所致小肠运动亢进有明显抑制作用，对阿托品致小肠运动减弱有协同作用．无毒棉籽抗泻下的机制可能与抑制副交感神经的兴奋有关     

葛根芩连汤配伍规律的研究

目的研究葛根芩连汤不同配伍对主要化学成分、药理效应变化的影响,综合分析该方的配伍规律。方法采用HPLC法测定各主要成分,考察HPCE指纹图谱的变化,药理指标采用体外抑菌、体内抑菌、解热试验、抗腹泻试验和病理损害模型。结果葛根和黄连降低黄芩苷的含量,黄连降低甘草酸的含量,葛根、黄芩、甘草使小檗碱的含量降低。配伍产生的沉淀,经分析含有黄芩苷、小檗碱、葛根素、甘草酸。各药配伍组合中,以黄连的体内外抑菌活性最强,不同的菌株强度有差异;解热试验中,最佳组合为葛根和黄芩;在抗腹泻试验中,最佳组合为黄连和炙甘草。结论从治疗“协热下利”证来说,全方4味药组合最佳。     

肠泻停胶囊止泻作用研究

目的 观察肠泻停胶囊的止泻作用。方法 采用新斯的明负荷肠推进亢进以及番泻叶、蓖麻油诱导的腹泻模型，通过测定肠推进百分率、腹泻潜伏期以及腹泻次数等指标来评价肠泻停胶囊的止泻作用，通过离体豚鼠回肠试验，观察其可能的作用机制。结果 肠泻停胶囊明显降低正常小鼠以及新斯的明负荷小鼠的小肠推进百分率；对口服番泻叶浸荆或蓖麻油所致的腹泻模型小鼠均有明显的保护作用；对豚鼠离体回肠的收缩幅度和张力有明显的抑制作用。结论 肠泻停胶囊具有明显的止泻作用。     

次水杨酸铋止泻作用的研究

目的通过动物实验研究次水杨酸铋的止泻作用。方法采用番泻叶致泻法、肠推进炭末排出时间、在体回肠运动和对全肠水分的影响等试验观察受试物的作用。结果次水杨酸铋可以对抗由番泻叶引起的腹泻，减少肠腔内水分的含量，减少肠内容积，但不影响肠蠕动。结论次水杨酸铋具有止泻作用，可防治多种病因引起的腹泻。     

阿是止泻胶囊治疗甲状腺功能亢进性腹泻的临床观察

目的通过对中药阿是止泻胶囊治疗甲状腺功能亢进(甲亢)性腹泻的临床观察,对该药有效性做出客观评价。方法临床治疗组用自拟方中药阿是止泻胶囊,对照组用复方苯乙哌啶片。结果阿是止泻胶囊治疗甲亢性腹泻总有效率为86．9％。结论阿是止泻胶囊具有较强的止泻作用。     

阿是止泻胶囊止泻的药效学及急性毒性实验研究

目的 :评价阿是止泻胶囊止泻的有效性和安全性。方法 :治疗组用自拟方阿是止泻胶囊 ,对照组用复方苯乙呱啶片。观察其对番泻叶所致小鼠腹泻的作用、对新斯的明所致小鼠小肠运动亢进的影响及急性毒性实验研究。结果 :阿是止泻胶囊可使小鼠湿粪数明显减少 ,使炭末在肠管的推进率降低 ,未测定出小鼠 1次灌胃给药L D50 ,其最大给药量 >2 0 g/ kg。结论 :该药有较强的止泻作用 ,临床应用安全可靠。     

Pharmacology and Toxicology of Extract from Arcangelisia gusanlung

Objective To study the pharmacology and toxicology of the extracts from Arcangelisia gusanlung (EAG). Methods The anti-inflammatory activities were investigated using various inflammatory models including ear edema induced by xylene in mice, paw edema induced by carrageenan, and cotton pellet granuloma in rats. The analgesic effect was observed in hot-plate test and writhing test in mice and the antipyretic effect was observed in rat fever model induced by yeast. The antitussive action was tested in mice by sequential method and expectorant action was evaluated by tracheal excretion of phenol red. The antidiarrhea function was observed on normal intestinal propulsion of mouse model of diarrhea induced by decoction of Sennae Folium. The toxicity was measured by toxicological experiment. Results Each dose of EAG could significantly inhibit the paw edema, cotton pellet granuloma, and intestinal propulsion. EAG significantly reduced writhing times and amount of wet manure. Obvious antipyretic action to fevered rat was observed. EAG obviously increased the tracheal excretion of phenol red and prolonged the latency of cough. No toxic reaction was shown in the observed period, and the maximum tolerance dose of mice was equivalent to 1360 times of common-used dose in human. Conclusion The clinical dosage of EAG is safe, and its anti-inflammatory, analgesia, antipyresis, antitussive, expectorant, and antidiarrhea effects are significant