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Effects of interleukin-1 (IL-1) blockers, CK130 and CK131, on IL-1-induced uveitis and proliferation of fibroblast-like corneal
and conjunctival cells were investigated in this study. It was found that CK130 and CK131 inhibited IL-1-induced uveitis in
rat eyes effectively at 3 mg/kg and 10 mg/kg, respectively. Further, CK130 and CK131 inhibited fibroblast-like corneal and
conjunctival cell growth effectively at 10–300 μg/ml and 30–300 μg/ml, respectively. It was also found that DNA synthesis
was markedly reduced by CK130 and CK131 at 30–100 μg/ml. RNA synthesis was also inhibited by these CK compounds but protein
synthesis was little affected or enhanced. 相似文献
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