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1.
Hiroaki YOSHIDA Tetsuya KAWAMURA Iekuni ICHIKAWA Osamu SAKAI 《Nephrology (Carlton, Vic.)》1997,3(S2):s719-s723
Summary: Clinical studies revealed that angiotensin converting enzyme (ACE) inhibitor reduces proteinuria and attenuates progressive decline in renal function in IgA nephropathy. Recent studies by us and others have demonstrated that the homozygote of the D allele (DD) of the ACE insertion/deletion (I/D) polymorphism is a potential risk factor for poor prognosis in IgA nephropathy, and that this deletion polymorphism predicts the therapeutic efficacy of ACE inhibition on proteinuria and, potentially, on progressive deterioration of renal function in patients with the nephropathy. 相似文献
2.
Schmidt S.; Giessel R.; Bergis K. H.; Strojek K.; Grzeszczak W.; Ganten D.; Ritz E.; the Diabetic Nephropathy Study Group 《Nephrology, dialysis, transplantation》1996,11(9):1755-1761
BACKGROUND.: There is agreement that a family history of hypertension (HT),is a predictor for the risk of diabetic nephropathy (DN) inpatients with type 2 diabetes, and possibly also type 1 diabetes.It follows that genes related to the risk of hypertension mustalso be considered candidate genes for DN. The 235T allele ofthe angiotensinogen gene was found to be related to primaryHT. METHODS.: To examine whether it is predictive for DN as well, we examinedthe angiotensinogen gene polymorphism in 230 healthy local controls,423 patients with type 1 diabetes (n=180 with DN; n=243 withoutDN) and 663 patients with type 2 diabetes (n=310 with DN; n=353without DN). The angiotensinogen gene M235T polymorphism wasdetermined using PCR amplification. RESULTS.: The following results were obtained (i) no significant differenceof genotype distribution (type 1: MM/MT/TT(%) 27.6/57.2/15.2vs. 27.2/56.1/16.7 (P=0.92); type 2: MM/MT/TT (%) 31.7/48.2/20.1vs. 32.9/46.8/20.3 (P=0.93)) or allele frequencies (type 1:M 0.56 vs. 0.55 (P=0.795); type 2: M 0.56 vs. 0.56 (P=0.86))was found, between diabetic patients with or without DN, (ii)no difference was found between normotensive and hypertensivediabetic patients. CONCLUSION.: The data argue against a role of the angiotensinogen gene M235Tpolymorphism in the manifestation of diabetic nephropathy orhypertension in diabetic patients. 相似文献
3.
血管紧张素原基因的六种单核苷酸多态与原发性高血压的相关性 总被引:7,自引:1,他引:7
目的 研究血管紧张素原 (angiotensinogen,AGT)基因 6个位点的单核苷酸多态及其构成的单倍型与中国汉族人原发性高血压的相关性。方法 采用多重SNa Pshot反应 ,在 185例原发性高血压患者和185名健康对照者中 ,对 AGT基因启动子区域的 G- 2 17A、G- 15 2 A、A- 2 0 C、G- 6 A及第 2外显子的T174 M和 M2 35 T多态进行基因分型。结果 6种单核苷酸多态的基因型分布及其等位基因频率在原发性高血压组和对照组中差异无显著性 (P>0 .0 5 )。单倍型分析提示由 - 15 2 A,- 2 0 C,- 6 A和 2 35 T等位基因构成的 H4单倍型在原发性高血压组中明显增加 ,与对照组相比差异有显著性 (P<0 .0 5 )。结论 AGT基因G- 15 2 A,A- 2 0 C,G- 6 A和 M2 35 T多态可能对中国汉族人原发性高血压的发病起了重要作用。 相似文献
4.
Relationship of polymorphisms in the renin-angiotensin system and in E-selectin of patients with early severe coronary heart disease 总被引:8,自引:0,他引:8
K. Wenzel A. Blackburn M. Ernst M. Affeldt R. Hanke G. Baumann S. B. Felix F. X. Kleber K. Rohde C. Gläser A. Speer 《Journal of molecular medicine (Berlin, Germany)》1997,75(1):57-61
Previous association studies between angiotensin-converting enzyme (ACE) and angiotensinogen (AGT) polymorphisms and several
cardiovascular diseases have reported variable results. Therefore we examined the association of the DNA variants of ACE and
AGT with early, severe coronary heart disease (CHD). In addition, we compared the genotypes of both polymorphisms and the
recently discovered polymorphism in the E-selectin gene in both patients and an unselected population. This study included
113 patients with severe CHD (50 years old or less) and up to 197 control subjects. The frequencies of the ACE I/D variants
were 48% I and 52% D in the controls and 46% I and 54% D in the patients. The frequencies of the AGT-M235T polymorphism were
60.8% M and 39.2% T in controls and 49.1% M and 50.9% T in the patients. The frequencies of the S128R polymorphism of the
E-selectin were 91.3% S and 8.7% R in controls and 84.5% S and 15.5% R in the patients. In our studies the DD genotype of
ACE was not associated with early severe CHD. We found a correlation between the M235T molecular variant of AGT and the S128R
variant of E-selectin to early severe CHD.
Received: 15 February 1996 / Accepted: 2 October 1996 相似文献
5.
Renin- angiotensin system( RAS) candidat-ing gene,such as angiotensinogen( Ag T) as wellas angiotensin- converting enzyme( ACE) genepolymorphism were thought to have positive association with various cardiovasculardiseases.In1 992 ,Jeunemaitre[1] detected a microsatellitepolymorphism in the region of the an-giotensinogen gene which has linked to occur-rence of essential hypertension.Further analysisled to detection of several mutations in the cod-ing region of angiotensinogen gene[2 ] . Ma… 相似文献
6.
[目的]探讨中国南方汉族人群中,血管紧张素转换酶(ACE)及血管紧张素原(AGT)双基因多态性与慢性心力衰竭发病的关系.[方法]用聚合酶链反应及限制性片段长度多态性技术检测111例慢性心力衰竭患者和110例健康者的ACE基因I/D及AGT基因M235T的多态性.[结果]①慢性心力衰竭组DD基因型与D等位基因的频率均高于对照组.DD基因型0.468比0.227,P<0.01;D等位基因0.667比0.436,P<0.01.②AGT基因M235T多态性在慢性心力衰竭组及对照组的分布无统计学差异.③ACE及AGT双位点多态性联合分析显示慢性心力衰竭组DD+TT基因型频率显著高于对照组(0.351比0.117,P<0.01),与Ⅱ+MM型者相比,具有该联合基因型者发生慢性心力衰竭的风险优势比(OR)为6.799,高于单基因分析的ACE-DD型者(OR=3.948).[结论]ACE基因I/D多态性与中国南方汉族人群慢性心力衰竭的发生有关,ACE基因DD型可能是该地区慢性心力衰竭发病的遗传危险因素;单独AGT基因M235T多态性与慢性心力衰竭的发生似无明显关系,但AGT及ACE基因在慢性心力衰竭的发生中具有交互作用,DD型者若同时携带TT基因型,发生慢性心力衰竭的危险性增高. 相似文献
7.
[目的]探讨中国南方汉族人群中,血管紧张素转换酶(ACE)及血管紧张素原(AGT)双基因多态性与慢性心力衰竭发病的关系.[方法]用聚合酶链反应及限制性片段长度多态性技术检测111例慢性心力衰竭患者和110例健康者的ACE基因I/D及AGT基因M235T的多态性.[结果]①慢性心力衰竭组DD基因型与D等位基因的频率均高于对照组.DD基因型0.468比0.227,P<0.01;D等位基因0.667比0.436,P<0.01.②AGT基因M235T多态性在慢性心力衰竭组及对照组的分布无统计学差异.③ACE及AGT双位点多态性联合分析显示慢性心力衰竭组DD+TT基因型频率显著高于对照组(0.351比0.117,P<0.01),与Ⅱ+MM型者相比,具有该联合基因型者发生慢性心力衰竭的风险优势比(OR)为6.799,高于单基因分析的ACE-DD型者(OR=3.948).[结论]ACE基因I/D多态性与中国南方汉族人群慢性心力衰竭的发生有关,ACE基因DD型可能是该地区慢性心力衰竭发病的遗传危险因素;单独AGT基因M235T多态性与慢性心力衰竭的发生似无明显关系,但AGT及ACE基因在慢性心力衰竭的发生中具有交互作用,DD型者若同时携带TT基因型,发生慢性心力衰竭的危险性增高. 相似文献
8.
目的探讨血管紧张素原(AGT)基因M235T和血管紧张素受体1(AT1R)基因A1166C多态性与飞行员原发性高血压的相关性,为飞行员原发性高血压的预防提供依据。方法用聚合酶链反应(PCR)和限制性酶切检测48例飞行员原发性高血压患者和50例飞行员健康对照者的AGT M235T和AT1R A1166C多态性。结果飞行员高血压组AGT M235基因型和等位基因频率与健康对照组有明显差异,而AT1R A1166C两组间差异无统计学意义。结论 AGT M235T基因多态性与飞行员原发性高血压相关。 相似文献
9.
肾素血管紧张素系统基因多态性与冠心病关系的研究 总被引:5,自引:0,他引:5
目的:探讨中国苏皖地区人群血管紧张素转换酶(ACE)和血管紧张素原(AGT)基因型的分布及其与冠心病的关系。方法:应用聚合酶链反应技术,对106例冠心病患者、56例冠状动脉造影正常者以及30名健康献血员ACE插入/缺失(I/D)多态性及AGTM235T多态性进行检测。结果:ACE基因型分布及等位基因频率在病例组及对照组间差异无显著性。病例组和对照组AGT基因型总体分布差异亦无显著性,而病例组T等位基因频率(0.778)显著高于对照组(0.698,P<0.05)。联合分析ACEDD型及AGT TT型罹患冠心病的相对风险,其比数比(OR)为3.61,高于单基因ACEDD型(1.23)及AGT TT型(1.77)。结论:AGTM235T基因多态性中T等位基因是中国苏皖地区人群冠心病发病的危险因素之一。同时具有ACE DD型及AGT TT型发生冠心病的相对风险显著高于单基因ACE DD型及单基因AGT TT型。 相似文献
10.
《Clinical and experimental hypertension (New York, N.Y. : 1993)》2013,35(5-6):713-726
Pre-eclampsia is characterised physiologically by plasma volume contraction, intravascular coagulation and intense vasoconstriction. It was originally thought that the renin-angiotensin-aldosterone (RAA) system would be overactive but studies have shown a more complex picture.Plasma renin activity (PRA) and concentration (PRC) and plasma angiotensin II (AII) and aldosterone concentrations (PAC) are reduced compared to normal pregnancy. Total renin concentration is normal and plasma concentrations of high molecular weight angiotensinogen are increased in pre-eclampsia though total angiotensinogen is normal.PRA and PRC respond appropriately to physiologic stimuli in pre-eclampsia except for impaired renin release following frusemide, possibly due to prostacyclin deficiency. Although plasma AII concentrations are reduced there is heightened pressor sensitivity to infused AII — the mechanism(s) for this are unknown. PAC is reduced but the ratio PAC:PRC is twofold greater in pre-eclampsia than normal pregnancy. This does not appear to be due to changes in potassium, atrial natriuretic peptide, dopamine or ACTH, and may be another manifestation of increased (adrenal) sensitivity to AII in pre-eclampsia.There is an inverse relationship between the plasma active renin to prorenin ratio and the clinical severity of pre-eclampsia. Understanding the mechanisms producing these changes in the RAA system in pre-eclampsia will give strong clues to the overall pathogenesis of this disorder. 相似文献