HPLC法测定滑膜炎颗粒中原儿茶醛的含量

目的建立滑膜炎颗粒剂中原儿茶醛的含量测定方法质量。方法采用高效液相色谱法对方中原儿茶醛进行含量测定。结果高效液相色谱法测定结果表明原儿茶醛在0．1005～1．005μg范围内呈线性关系，平均加样回收率为99．22％；RSD为0．72％。结论本法简便，重现性好、结果可靠，可作为控制滑膜炎颗粒剂的质量方法。     

粮谷尘致肺损害的实验研究

粮谷尘为混合性粉尘，含游离ＳｉＯ２９．７７％，分离培养出普通高温放线菌。染尘动物肺脏早期病变主要为小灶性肺泡炎、灶性间质性肺炎、异物肉芽肿等，大、中支气管壁脱颗粒肥大细胞增多。９０ｄ以后，上述病变明显减少，但逐渐出现少数小的细胞结节，间质轻度纤维组织增生、支气管慢性炎症和小叶中央型肺气肿样病变，观察１ａ（年）未见明显纤维化。     

维吾尔药孜尔克中总黄酮、微量元素及脂肪含量的测定

目的:对维吾尔医药孜尔克中总黄酮、微量元素及脂肪含量进行测定。方法:采用分光光度法,测定孜尔克的根和果实中总黄酮的含量。采用索氏抽提法提取并测定孜尔克的根和果实的脂肪含量。用原子吸收分光光度法测定孜尔克中根和果实中钙、铁、钠、钾、铜、锌、锰7种微量元素。结果:总黄酮在0.006~0.06mg.ml-1之间与吸光度有良好的线性关系。回归方程:C=0.0732A-0.002267(mg.ml-1)。相关系数R2=0.9916。元素测定中钙、铁含量较高。结论:本法操作简便,快速,为进一步研究和综合开发利用这一民族药材提供了依据。     

耳穴贴压治疗寻常痤疮对血清睾酮雌二醇的影响

目的:观察耳穴贴压对内分泌的调节作用,探讨其治疗痤疮的作用机理.方法:采用耳穴贴压法治疗寻常性痤疮37例,并用放射免疫分析法检测治疗前后患者血清性激素的变化.结果:经2疗程治疗,患者血清睾酮治疗前后无明显差异(P>0.05);血清雌二醇及睾酮/雌二醇值治疗前后差异均有显著性意义(P<0.05或P<0.01).结论:耳穴贴压具有调节性激素作用,使雌二醇增高,雄激素相对地降低,降低了睾酮/雌二醇值,从而达到治疗痤疮的目的.     

三黄消疕膏治疗寻常型银屑病血热证的临床疗效观察

目的:探讨三黄消疕膏用于治疗寻常型银屑病血热证的临床效果和安全性。方法:选取2017年12月-2018年11月就诊于我院的寻常型银屑病患者80例,根据随机数字表法,分为治疗组和对照组,对照组口服决银颗粒治疗,治疗组除口服决银颗粒外,外用三黄消疕膏于局部皮损处,治疗2周后,分别对两组患者进行皮损面积及严重程度(Psoriasis Area and Severity Index,PASI)评分、皮肤病生活质量指数(Dermatology Life Quality Index,DLQI)评分、有效率、不良反应发生率评分。结果:治疗后,两组患者PASI评分下降,差异有统计学意义(t=3.34,P<0.05);DLQI评分下降,差异有统计学意义(t=5.59,P<0.05);治疗组有效率为91%,对照组有效率为62%,差异有统计学意义(χ^2=30.09,P<0.01);两组患者治疗后不良反应发生率较低,差异无统计学意义(P>0.05)。结论:三黄消疕膏联合决银颗粒治疗寻常型银屑病血热证可取得较好的临床效果,且安全性较高,值得推广。     

Clinical and usability study to determine the safety and efficacy of the Silk'n Blue Device for the treatment of mild to moderate inflammatory acne vulgaris

Abstract

Introduction: Home devices for acne vulgaris have emerged as a way to utilize our current light based technology for the care of our patients suffering from acne vulgaris. Materials and methods: Patient received eight treatments with the Silk'n Blue device over a 4-week period. Follow-up visits were at 1 month and 3 months. Results: Seventeen subjects were entered into this institutional review board (IRB) approved clinical research project. There was a statistically significant decrease in mean acne counts from baseline through the follow-up visits, p = 0.002. Percent reduction was also statistically significant, p = 0.041. The study also showed that 36.4% of the patients had complete clearance with the study device. 100% of the patients showed full comprehension with the label for the device. There were no adverse events. Photos were captured. Discussion: The Silk'n Blue device has an array of 24 LEDs emitting a spectrum of light in the blue-violet range of light (405–460 nm). Subjects enrolled in this clinical trial clearly were able to understand the labeling for the device. Conclusions: The Silk'n Blue device is a safe efficacious at home device for the treatment of mild to moderate inflammatory acne vulgaris.     

狗尾草治疗寻常疣与鸡眼的临床观察

目的：为了探究狗尾草治疗寻常疣与鸡眼的临床疗效；方法：采用狗尾草新鲜茎汁治疗寻常疣，并与鸭胆子进行比较；采用鲜品狗尾草治疗鸡眼。结果：狗尾草与鸭胆子治疗寻常疣有效率都比较高，疗效基本相当；狗尾草治疗鸡眼有很好疗效。结论：狗尾草治疗寻常疣与鸡眼等方面具有独到的疗效。     

消银胶囊联合复方甘草酸苷治疗寻常型银屑病

目的观察消银胶囊联合复方甘草酸苷治疗寻常型银屑病的临床疗效。方法将本院2009年1月～2011年6月收治的63例寻常型银屑病患者随机分为两组,对照组29例,口服消银胶囊5粒,3次/d,转移因子胶囊3mg,2次/d,同时外用复方氟米松软膏。治疗组34例在此基础上加用复方甘草酸苷片50mg,3次/d,两组均治疗6周观察疗效。结果治疗组治疗后PASI评分为（3.61±2.26）分,低于对照组的（7.3±1.7）分,差异有统计学意义（P〈0.05）;两组患者治疗后的有效率分别为85.3%、65.5%,两组比较差异有统计学意义（P〈0.05）;两组患者治疗前后血、尿常规、肝肾功能等各项指标均未见异常。结论消银胶囊联合复方甘草酸苷治疗寻常型银屑病可明显提高疗效,值得临床应用。     

NB—UVB照射联合中药对寻常型银屑病血热型患者IL-17、IL-22、IL-23的影响

目的：观察窄谱中波紫外线（NB—UVB）照射联合中药对寻常型银屑病血热型患者的血清白介素（IL）-17、IL-22、IL-23的影响。方法：40例寻常型银屑病血热型患者随机分为中药组和联合组各20例。中药组采用1：2服凉血活血汤治疗,联合组在中药组治疗基础上采用NB—UVB照射治疗。采用ELISA法对40例患者治疗前后和10例对照组的健康志愿者血清中的IL-17、IL-22、IL-23水平进行检测。结果：治疗前中药组、联合组IL-17、IL-22、IL-23水平均显著高于对照组,差异均有非常显著性意义（P〈0．01）。中药组、联合组治疗前后自身IL-17、IL-22、IL-23水平比较,差异均有非常显著性意义（P〈0．01）。治疗后中药组、联合组3项指标分别与对照组比较,差异均有非常显著性意义（P〈0．01）;中药组、联合组治疗后3项指标比较,差异有非常显著性意义（P〈0．01）。结论：NB—UVB照射联合中药对寻常型银屑病血热型患者的免疫功能有一定影响,且优于单纯中药治疗。     

Lupus vulgaris with tubercular lymphadenitis and IgA nephropathy

A 14-year-old girl presented with a 10-year history of a large crusted plaque over the right thigh for 10 years and small reddish plaque over the left upper back for 3 months. On routine evaluation, she was found to have hematuria. Skin biopsy from the lesion was suggestive of skin tuberculosis (lupus vulgaris), and kidney biopsy showed features of IgA nephropathy (IgAN). Fine-needle aspiration from the inguinal lymph node was consistent with granulomatous disease. The patient has been on anti-tubercular treatment, and the hematuria has subsided.