Clinical Effectiveness of Erlova in EGFR-Mutated Non-Small Cell Lung Cancer: An Affordable Price with Clinical Benefit

Background: Thyrosin kinase inhibitors (TKIs) is approved for the first line treatment of non-small cell lung cancer (NSCLC) patients with  epidermal growth factor receptor (EGFR) mutation. This study performed to assess clinical effectiveness and safety of Erlova (generic form of Erlotinib). Methods: Somatic mutations of EGFR gene were studied in tumor tissue by polymerase chain reaction (PCR) and bi-directional sequencing in 513 chemonaive and histologically verified lung adenocarcinoma Iranian patients. Patients  with EGFR mutation received Erlova at 150 mg/day  as first line treatment. Primary endpoint was progression free survival (PFS). Results: About 21% (n=109) cases had EGFR mutation. Most EGFR mutations were  occurred at exon 19. Among them, sixty nine patients treated with Erlova. Median PFS was 11.4 months and objective response rate (ORR) was about  88%. Most frequent treatment related adverse events was  skin rash. Conclusion: Our findings showed Erlova had remarkable effectiveness. In  mutation-positive patients with EGFR, Erlova can be used  safely instead of  other tyrosine-kinase inhibitors.     

心达康滴丸联合地尔硫卓治疗冠心病心绞痛的临床研究

目的探讨心达康滴丸联合盐酸地尔硫卓片治疗冠心病心绞痛的临床疗效。方法选择2018年7月—2019年7月在武汉市江夏区中医医院治疗的冠心病心绞痛患者94例,根据用药的差别分成对照组(47例)和治疗组(47例)。对照组口服盐酸地尔硫卓片,30mg/次,3次/d;治疗组在对照组基础上口服心达康滴丸,18粒/次,3次/d。两组患者均经4周治疗。观察两组患者临床疗效,同时比较治疗前后两组患者心绞痛发作次数和持续时间,临床症状积分、SAQ和GQOLI-74评分,血清C反应蛋白(CRP)、S100钙结合蛋白A12(S100A12)、白细胞介素-18(IL-18)、妊娠相关血清蛋白A(PAPP-A)、内皮素-1(ET-1)和肌钙蛋白I(CTnI)水平及心功能。结果治疗后,对照组和治疗组临床有效率分别为80.85%和97.87%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者心绞痛发作次数及持续时间都显著改善降低(P0.05),且治疗组比对照组改善更显著(P0.05)。治疗后,两组患者SAQ积分和GQOLI-74评分均明显升高,而临床症状积分明显降低(P0.05),且治疗组这些评分明显好于对照组(P0.05)。治疗后,两组患者血清CRP、S100A12、IL-18、PAPP-A、ET-1、CTnI水平均明显降低(P0.05),且治疗组明显低于对照组(P0.05)。治疗后,两组患者左心室射血分数(LVEF)和心排血量(CO)均升高,而左室收缩末期内径(LVESD)明显降低(P0.05),且治疗组LVEF、CO和LVESD比对照组改善更明显(P0.05)。结论心达康滴丸联合盐酸地尔硫卓片治疗冠心病心绞痛可明显改善患者临床症状,改善生活质量,具有一定的临床推广应用价值。     

克林霉素在老年患者呼吸道感染中的应用

目的:探讨克林霉素在老年呼吸道感染中的应用价值.方法:38例老年呼吸道感染惠者随机分为治疗组(克林霉素)和对照组(青霉素 丁胺卡那霉素),观察临床疗效.结果:治疗组在退热时间和治疗时间上均短于对照组,差异具有显著性意义,而副反应少而轻微.结论:克林霉素治疗老年呼吸道感染安全有效.     

盐酸丁卡因滴眼液的稳定性研究

目的 :考察 1 %盐酸丁卡因滴眼液的稳定性 ,确定其有效贮存期。方法 :采用经典恒温法预测其有效期。结果 :经典恒温法[1 ] 预测室温贮存期约为 2 0d ,冰箱贮存期约为 1 1 0d。结论 :该制剂对热不稳定 ,应冷藏。     

The depressing effect of tetracaine and ryanodine on the slow outward current correlated with that of contraction in voltage-clamped frog muscle fibres

The effects of tetracaine (10–50 M) and ryanodine (0.1–10 M) were tested on the slow outward K⁺ current (I _so) and the mechanical tension of isolated frog muscle fibres in a voltage-clamp device (double mannitol-gap) connected to a mechanoelectric transducer. In the concentration range tested, both drugs induced a simultaneous inhibition of tension and current. In all cases the effect on tension was twice that on current. The tetracaine-induced current and tension blocks were fully reversible and dose-dependent. In contrast the ryanodine effects on current and tension were not reversible and did not exhibit a dose dependence except for the delay before the onset of the response, which was shortened when the concentration was raised. Linear regression analysis of the time-dependent and dose-dependent effects of both drugs indicated a strong correlation between the decreases in tension and current. It is concluded that the slow outward current is partly under the control of the Ca²⁺ release from sarcoplasmic reticulum during contraction.     

三种药物防治胃肠肿瘤化疗所致呕吐的临床研究

目的：评价三种药物防治胃肠肿瘤化疗所致呕吐的价值。方法：９０名患者随机分成三组,灭吐灵组（Ａ组）,吗丁啉组（Ｂ组）,枢丹组（Ｃ组）。应用５－Ｆｕ＋ＬＶ方案化疗５天,观察５天内三种药物的止吐效果。结果：Ａ和Ｂ、Ｃ组比较有显著性差异（Ｐ〈０．０５）,Ｂ和Ｃ比较无显著性差异（Ｐ〉０．０５）。结论：Ｂ组副作用少,疗效高,建议临床推广使用吗丁啉。     

盐酸洛美沙星左氧氟沙星治疗泌尿生殖系感染

目的观察评价盐酸洛美沙星与左氧氟沙星治疗泌尿系感染的疗效及安全性.方法69例病人随机分成两组,治疗组38例,用盐酸洛美沙星0.2g,po,bid;对照组31例,用左氧氟沙星0.1g,po,tid,疗程均为7～14d.结果治疗组临床有效率为92.1%,细菌清除率为91.5%;对照组分别为90.3%和92.5%;两组间无显著性差异(P＞0.05).结论盐酸洛美沙星治疗泌尿生殖系感染疗效确切,安全方便,不良反应小.     

不同过滤方法对盐酸乙胺丁醇片含量测定的影响

目的：探讨盐酸乙胺丁醇片含量测定中使用不同过滤方法对测定结果的影响。方法：采用全玻璃砂芯滤器过滤可排除滤纸对主药的吸附。结果：方法平均回收率为99．0％，RSD为0．17％。结论：本法准确，可靠。     

葛根素治疗颈性眩晕临床观察

以葛根素加半夏白术天麻汤治疗颈性眩晕45例，为治疗组；以西北灵加半夏白术天麻汤治疗42例，为对照组。通过两组临床疗效观察：治疗组显效27例，有效16例，无效2例，有效率为96．0％；对照组显效8例，有效24例，无效10例，有效率为77．0％，对比有显著性差异（P＜0．01）。     

RP-HPLC法测定盐酸哌唑嗪片的含量及有关物质

目的　以HPLC法测定盐酸哌唑嗪片的含量及有关物质。方法　采用Zorbax SB-C₁₈色谱柱(250mm×4.6mm ,5μm) ,流动相为甲醇-水-冰醋酸-三乙胺(490∶460∶45∶5) ,流速为1.0ml·min^-1,柱温30℃,检测波长为247nm ,用外标法测定。结果　盐酸哌唑嗪的保留时间约为4.2min ,且与其它峰的分离度大于1.5。盐酸哌唑嗪的线性范围为5～50μg·ml^-1(r=0.9999) ,最低检测限为0.4ng·ml^-1,平均回收率和RSD分别为100.8%和0.68%。结论　该方法简便、快速,结果准确可靠,适用于盐酸哌唑嗪片的含量及有关物质的定量检测。