长期生存癌症患者的述情障碍

目的：探讨长期生存癌症患者的述情障碍及其相关因素，方法：采用多伦多述情障碍量表及症状自评量表，对36例长期生存癌存患者测评，并与45例正常人进行对照比较，结果：（1）癌症组与对照组在SCL－90评价中无显著性差异（P＞0．05）。（2）癌症组TAS总分值明显高于对照组，其中以Ⅱ、Ⅲ、Ⅳ因子尤为明显（P＜0．05－0．01）。（3）Ⅰ因子与躯体化、焦虑、恐怖焦虑及精神病症呈显著性正相关（P＜0．05）。Ⅲ因子与强迫性，人际关系敏感，敌意及精神病症呈显著性负相关（P＜0．05）。Ⅳ因子与偏执化呈显著性负相关（P＜0．05）。结论：长期生存癌症患者虽然SCL－90测评可正常，但存在较明显的述情障碍。     

Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method,in patients undergoing peritoneal dialysis,hemodialysis, and kidney transplantation

Background: The level and activity of indoleamine 2,3-dioxygenase (IDO) and the concentrations of L-tryptophan and its metabolite L-kynurenine were determined in association with various renal diseases. However, there have been no data regarding these parameters in patients on peritoneal dialysis compared to those undergoing hemodialysis or kidney transplantation.

Methods: This study investigated the level and activity of IDO and determined oxidative balance by calculating the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI). We enrolled 60 kidney disease patients, including 20 on peritoneal dialysis (PD group), 19 on hemodialysis (HD group), and 21 with kidney transplantation (KT group), as well as 21 control group.

Results: IDO levels were increased in the PD, HD, and KT groups compared to the control group. The concentration of kynurenine was significantly increased in the PD group compared to the other groups (p?p?TAS levels in the PD and HD groups were significantly decreased compared to the control group (both p?TAS levels in the PD group were significantly decreased compared to the KT group. TOS levels in the PD group were higher than in the HD and KT groups.

Conclusion: The results showed that IDO levels were increased in peritoneal dialysis and hemodialysis patients and in renal transplant recipients, while oxidative stress was found to be related to IDO activity and was most increased in the patients on peritoneal dialysis.     

Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning

Several studies have used taste sensitivity to 6-n-propylthiouracil (PROP) to evaluate interindividual taste variability and its impact on food preferences, nutrition, and health. We used a supervised learning (SL) approach for the automatic identification of the PROP taster categories (super taster (ST); medium taster (MT); and non-taster (NT)) of 84 subjects (aged 18–40 years). Biological features determined from subjects were included for the training system. Results showed that SL enables the automatic identification of objective PROP taster status, with high precision (97%). The biological features were classified in order of importance in facilitating learning and as prediction factors. The ratings of perceived taste intensity for PROP paper disks (50 mM) and PROP solution (3.2 mM), along with fungiform papilla density, were the most important features, and high estimated values pushed toward ST prediction, while low values leaned toward NT prediction. Furthermore, TAS2R38 genotypes were significant features (AVI/AVI, PAV/PAV, and PAV/AVI to classify NTs, STs, and MTs, respectively). These results, in showing that the SL approach enables an automatic, immediate, scalable, and high-precision classification of PROP taster status, suggest that it may represent an objective and reliable tool in taste physiology studies, with applications ranging from basic science and medicine to food sciences.     

Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals

Diet and salivary proteins influence the composition of the oral microbiome, and recent data suggest that TAS2R38 bitter taste genetics may also play a role. We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota. 6-n-Propylthiouracil (PROP) super-tasters (ST, n = 10) and non-tasters (NT, n = 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (p = 0.012) but not after the intervention (p = 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (p = 0.023) but not in STs (p = 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health.     

腹部超声与阴道超声在异位妊娠诊断中的价值

目的:探讨经腹部超声(TAS),经阴道超声(TVS),以及两者联合检查诊断异位妊娠的优缺点,以提高异位妊娠的早期诊断率。方法:对本院5年来收治的197例异位妊娠患者进行回顾性分析,对比两种超声检查方法的阳性确诊率。结果:197例中75例经TAS检查诊断62例,阳性确诊率82.3%;72例经TVS检查诊断65例,阳性确诊率90.3%,50例经TAS和TAS联合诊断49例,阳性确诊率98%。结论:TVS在急诊型异位妊娠诊断中有优势,TVS在相对稳定型异位妊娠诊断中有明显优势,两者联合应用能取长补短,有效提高阳性确诊率。     

419名中小学生考试焦虑的调查分析

目的了解中小学生考试焦虑的状况。方法考试焦虑量表(TAS)对419名11～20岁小学生、初中生和高中生进行调查分析。结果24.1%的调查对象存在问题性考试焦虑,其中,小学、初中和高中的检出率为14.2%、32.1%和26.7%。结论中小学生均存在不少的考试焦虑的问题,应予关注。     

精神分裂症患者的述情障碍及影响因素研究

本文用多伦多述情障碍量表（ＴＡＳ）对８０例恢复期住院精神分裂症患者进行测评。结果表明，８０例患者的ＴＡＳ平均得分为７２．６±１１．９，ＴＡＳ得分与ＢＰＲＳ评分（ｒ＝０．２７，Ｐ＜０．０５）、ＳＡＮＳ评分（ｒ＝０．２２，Ｐ＜０．０５）、患者用药剂量（ｒ＝０．２３，Ｐ＜０．０５）和患者的妄想（ｒ＝０．２３，Ｐ＜０．０５）、思维贫乏（ｒ＝０．２４，Ｐ＜０．０５）、意志缺乏（ｒ＝０．２８，Ｐ＜０．０５）因子分呈显著正相关，与ＳＡＰＳ总分、患者的年龄、病程、住院次数和本次住院天数相关性不显著（Ｐ＞０．０５）。多元逐步回归分析揭示：与医生护士谈心的机会较少、用药剂量较大、与家人的感情交流较少和家庭和睦程度较差为患者述情障碍发生的主要影响因素。     

Regorafenib联合TAS102新策略治疗肝细胞癌的研究

背景 与目的:瑞格菲尼(regorafenib,REG)和TAS102是治疗消化道肿瘤的新型药物.嘧啶类药物5-氟尿嘧啶(5-fluorouracil,5-FU)联合REG可抑制多药耐药转移性结肠癌的进展.肿瘤干细胞(cancer stem cell,CSC)决定肿瘤的自我更新,异质性及治疗耐受等,靶向CSC为治愈肿瘤...     

Intrarater and interrater reliability of a hand-held dynamometric technique to quantify palmar thumb abduction strength in individuals with and without carpal tunnel syndrome

Study Design

Clinical measurement.

Effect of substrate thermal resistance on space-domain microchannel fluorescent melting curve analysis

In recent years, Fluorescent Melting Curve Analysis (FMCA) has become an almost ubiquitous feature of commercial quantitative PCR (qPCR) thermal cyclers. Here a micro-fluidic device is presented capable of performing FMCA within a microchannel. The device consists of modular thermally conductive blocks which can sandwich a microfluidic substrate. Opposing ends of the blocks are held at differing temperatures and a linear thermal gradient is generated along the microfluidic channel. Fluorescent measurements taken from a sample as it passes along the micro-fluidic channel permits fluorescent melting curves to be generated. In this study we measure DNA melting temperature from two plasmid fragments. The effects of flow velocity and ramp-rate are investigated, and measured melting curves are compared to those acquired from a commercially available PCR thermocycler.