思密达治疗婴幼儿腹泻86例临床实验

目的 评价思密达治疗婴幼儿腹泻的疗效。方法 思密达口服治疗婴幼儿腹泻。病例为儿科门诊病人,年龄２－６０个月,疗程在３天内,症状为排稀水样便。就诊前未服用过本组实验组物的腹泻病人１７３人,随机分二组,分别给予服思密达或黄连素片。结果 治疗组平均疗程２．９３天,对照组４．４７天,ｘ＾２＝４．３９,ｐ〈０．０５。思密达总有效率９４．１％,对照组７９．３％,ｘ＾２＝１３．８,ｐ〈０．０１。两组结果比较,差     

思密达治疗小儿轮状病毒肠炎临床观察

目的　为了研究思密达治疗小儿轮状病毒肠炎的效果。 方法　 我们于 2 0 0 1年 5月～ 2 0 0 2年 3月在儿科门诊及住院病人中选择了 14 5例 ,随机分为治疗组和对照组 ,6天总有效率分别为 98%和 90 % ,有显著性差异 (P <0 0 5 )。治疗组平均恢复时间为 3d ,对照组为 4d(P <0 0 1) ,同时在主要观察指标治疗组均明显优于对照组 ,两者差异有显著性 (P <0 0 5 )。 结果　提示口服思密达治疗小儿轮状病毒肠炎与对照组疗效相比 ,差异有显著性。 结论　 思密达治疗小儿轮状病毒性肠炎能缩短病程安全有效。     

思密达联合左氧氟沙星治疗成人急性感染性腹泻60例临床观察

目的：观察恩密达联合左氧氟沙星治疗成人急性感染性腹泻的疗效。方法：所选病例分成A组(60例)、B组(27例)和C组(30例)。给予A组患者恩密达每次1袋(3g)，每日3次，左氧氟沙星每次0.2g，每日2次；给予B组患者恩密达每次一袋(3g)，每日3次；给予C组患者左氧氟沙星，每次0.2g，每日2次。3组疗程均为3天。结果：A组显效51例，有效8例，总有效率达98．30％；B组显效19例，有效3例，总有效率达81．48％；C组显效20例，有效5例，总有效率达86．66％。结论：思密达联合左氧氟沙星治疗成人急性腹泻，疗效高，安全，且不影响抗生素吸收。     

Comparative efficacy of dioctahedral smectite (Smecta) and a probiotic preparation in chronic functional diarrhoea

The present study was designed to investigate the clinical efficacy and safety of dioctahedral smectite in Chinese patients with chronic functional diarrhoea and to compare this activity to a probiotic preparation.

Patients diagnosed with chronic functional diarrhoea (Rome II criteria), exclusion of blood, ova/parasites in the stool and a normal colonoscopy were included. After a 1-week period of baseline without any medication, they were prescribed three sachets of dioctahedral smectite 3 g, administered 1 h after the meals (Group A), or two capsules of Bifico 210 mg (Group B) for 28 consecutive days. Efficacy of the treatments was assessed on frequency of bowel movements and consistency of stool, as compared to baseline.

Four hundred and ten patients were included (258 males, 152 females; mean age 43.8 ± 13.9 years): 208 in Group A and 202 in Group B. In Group A, the mean number of stool per day decreased from 3.5 ± 1.0 at baseline to 2.0 ± 0.9 and from 3.3 ± 1.0 to 2.2 ± 0.9 in Group B (z = 2.699; P = 0.007). Decrease in stool number was significant with both treatments but more important with smectite at week 2 and remained significant throughout the treatment period. Stool consistency, assessed by the Bristol scale, also improved significantly over the treatment period, as compared to baseline (z = 3.310, P = 0.001).

Dioctahedral smectite appeared in this study to be an effective and safe treatment of chronic functional diarrhoea, its effect starting during the first week of treatment and consisting in a decrease in the frequency of daily bowel movements and improvement of stool consistency. Moreover, dioctahedral smectite displays a prolonged action after disruption of the treatment that may interfere with the natural course of the disease.     

家兔体内思密达对左氧氟沙星药动学的影响

目的:探讨口服思密达和左氧氟沙星后左氧氟沙星的药动学有无改变。方法:取家兔6只随机交叉(间隔1周)经口灌胃左氧氟沙星(A组)、左氧氟沙星+思密达(B组)、左氧氟沙星2h后+思密达(C组)。采用高效液相色谱法测定不同时间血样中左氧氟沙星浓度,计算并比较药动学参数。结果:A组与C组比较,Cmax、tmax、AUC、t1/2均无显著性差异(P>0.05);B组除tmax与其它组无差异外(P>0.05),t1/2延长,AUC、Cmax值降低(P<0.05)。结论:同时使用左氧氟沙星和思密达,可明显改变前者的药动学参数;使用左氧氟沙星2h后再用思密达,此用药方案较为合理。     

儿泻康贴膜治疗婴幼儿腹泻的临床研究

为观察儿泻康贴膜治疗婴幼儿腹泻的临床疗效,以思密达为对照随机分组各治疗30例轻型腹泻病患儿,比较两组的疗效以及疗效与辨证分型的关系。结果显示儿泻康贴膜在有效率和对脾虚泻的疗效方面作用与思密达相似,在治愈率和对风寒泻的疗效方面作用显著优于思密达。     

六味木香胶囊加思密达治疗腹泻型肠易激综合征的临床研究

目的：研究六昧木香胶囊加思密达对腹泻型肠易激综合征的疗效。方法：将87例腹泻型肠易激综合征患者随机分为2组。对照组43例口服思密达，治疗组44例口服思密达加六昧木香胶囊。均治疗4N，随访3个月并比较两组的疗效。结果：治疗组的显效率（52．3％）和有效率（88.6％）均高于对照组（27．9％，60．5％），差异有显著性（P〈0．05）。对照组复发率明显高于治疗组，差异有显著性（P〈0．05）。结论：六昧木香胶囊加思密达是治疗肠易激综合征的一种有效方法。     

山东蒙脱石与思密达止泻作用的比较研究

目的:比较山东产蒙脱石与思密达(smecta)的止泻作用功效。方法:实验对用硫酸镁、大黄粉、蓖麻油制成小鼠腹泻模型分别给予15.6％、31.2％蒙脱石、31.2％思密达,观察蒙脱石和思密达对模型小鼠胃肠推进速度及腹泻次数的影响;给予家兔空肠局部0.2％乙酰胆碱50 μl,观察国产蒙脱石和思密达对其所致空肠过度收缩的影响。结果:实验结果表明,山东蒙脱石和思密达均能显著地降低硫酸镁和大黄粉所致的胃肠过度运动的推进速度,降低腹泻次数;抑制乙酰胆碱所致的小肠过度收缩。结论:山东蒙脱石在相同剂量下,其止泻药效作用与法国进口药思密达相同,可有效地吸附肠内有害物质,是一具有较好前景的止泻中药。     

腭裂术后患者回访及语音治疗效果分析

目的通过腭裂术后患者腭咽闭合功能检查及进行相应语音治疗，观察腭裂术后语音改善情况，从而进行针对性治疗，提高腭裂治疗水平。方法通过对31例腭裂术后患者跟踪回访，集中语音训练，了解腭裂术后腭咽闭合功能恢复情况，并对语音清晰度进行评估。结果通过语音治疗，多数患者腭咽闭合功能恢复并不理想，发音清晰度不能明显提高。结论腭裂术后腭咽闭合功能不一定得到完全恢复，定期回访及语音治疗，对了解患者发音改善情况及确定进一步针对性治疗，提高腭裂治疗水平有很大的意义。     

羧甲淀粉钠应用于小儿口腔炎患者74例的临床疗效观察与探讨

目的探讨羧甲淀粉钠治疗小儿口腔炎的临床效果。方法74例患者被随机分为实验组(n=38)和对照组(n=36),对照组给予思密达治疗,实验组给予羧甲淀粉钠和利多卡因治疗。结果两组在总有效方面无显著性差异(P>0.05),但在痊愈率方面有显著性差异(P<0.05)。对照组为66.7%,实验组达到86.8%,实验组显著优于对照组。结论羧甲淀粉钠联合利多卡因治疗小儿口腔炎安全有效,且能显著提高治疗效果,值得在临床上应用和推广。