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柴胡皂甙q及其甙元的结构鉴定 总被引:4,自引:0,他引:4
从小叶黑柴胡(Bupleurum smithii Wolffvar;parvifolium ShanetY.Li)的根中得到3个化合物,柴胡皂甙元A和Q及柴胡皂甙q。柴胡皂甙元Q和柴胡皂甙q为新化合物,根据理化性质和波谱分析,确定其结构分别为齐墩果烷-11,13(18)-二烯-3β,16β,23,28,30-五醇和3β,16β,23,28,3O-五羟基齐墩果烷-11,13(18)-二烯-3-O-β-D-吡喃葡萄糖基(1→6)-[α-L-吡喃鼠李糖基(1→4)]-β-D-吡喃葡萄糖甙。 相似文献
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Siqi Ren Jingjing Liu Yunwen Xue Mei Zhang Qiwei Liu Jie Xu Zunjian Zhang Rui Song 《Journal of Pharmaceutical Analysis》2021,11(4):435
Saikosaponins (SSs) are the main active components extracted from Bupleuri Radix (BR) which has been used as an important herbal drug in Asian countries for thousands of years. It has been reported that the intestinal bacteria plays an important role in the in vivo disposal of oral SSs. Although the deglycosylated derivatives (saikogenins, SGs) of SSs metabolized by the intestinal bacteria are speculated to be the main components absorbed into the blood after oral administration of SSs, no studies have been reported on the characteristics of SGs for their intestinal absorption, and those for SSs are also limited. Therefore, a rapid UHPLC-MS/MS method was developed to investigate and compare the apparent permeability of three common SSs (SSa, SSd, SSb2) and their corresponding SGs (SGF, SGG, SGD) through a bidirectional transport experiment on Caco-2 cell monolayer model. The method was validated according to the latest FDA guidelines and applied to quantify the six analytes in transport medium samples extracted via liquid-liquid extraction (LLE). The apparent permeability coefficient (Papp) determined in this study indicated that the permeability of SGs improved to the moderate class compared to the corresponding parent compounds, predicting a higher in vivo absorption. Moreover, the efflux ratio (ER) value demonstrated an active uptake of SSd and the three SGs, while a passive diffusion of SSa and SSb2. 相似文献
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自黑柴胡(Buplcurum smithii Wolff)根中分得9个三萜皂甙和1个三萜皂甙元。根据理化性质和波谱分析,其中5个皂甙和1个皂甙元分别鉴定为柴胡次皂甙A(Ⅱ,prosaikogenin A),柴胡次皂甙D(Ⅲ,prosaikogenin D),柴胡皂甙b_1(V,saikosaponin b_1),柴胡皂甙g(VI_a,saikosaponing),柴胡皂甙b_2(Ⅶ,saikosaponin b_2)和柴胡皂甙元A(I,saikogenin A),均为首次从该植物中分离得到,尚有4个新皂甙的结构鉴定将另文报道。 相似文献
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