性别对罗库溴铵药效的影响

目的探讨性别对罗库溴铵起效时间、无反应期和恢复指数的影响。方法择期行全身麻醉手术患者60例,根据性别将患者分为男性组和女性组,各30例。5s内静脉推注罗库溴铵0．9mg／kg,记录从推药到T1达0％的时间（起效时间）、无反应期（T1为0％的时间）和恢复指数（T1由25％至75％的时间）。结果男性组和女性组的起效时间分别为（69±20）和（70±17）s,无反应期分别为（40±12）和（45±11）min,恢复指数分别为（22q-6）和（23±4）rain,2组的起效时间、无反应期和恢复指数的组间比较差异无统计学意义（P〉0．05）。结论按0．9mg／kg罗库溴铵给药,性别对其起效时间、无反应期和恢复指数无影响。     

罗库溴铵联合高频控制通气用于婴幼儿气管异物取出术

目的 研究罗库溴铵联合高频控制通气用于婴幼儿气管异物取出术的麻醉效果.方法 42例ASA I～Ⅱ级行气管异物取出术的患儿,随机分为罗库溴铵组(R组)和对照组(C组),每组21例.R组静脉注射咪唑安定、氯胺酮、罗库溴铵麻醉,消除自主呼吸,插入支气管镜后经侧孔高频控制通气;C组静脉注射咪唑安定、氯胺酮、芬太尼、丙泊酚麻醉,保留自主呼吸,插入支气管镜后经侧孔辅助通气.术中连续监测心电图(ECG)、心率(HR)、呼吸(RR)、脉搏血氧饱和度(SpO2),记录低氧血症、呛咳、气道痉挛等不良反应的发生次数、手术时间、苏醒时间及苏醒期并发症.结果 R组术中不良反应及苏醒期并发症发生率较C组明显降低(P<0.05),手术及苏醒时间较C组明显缩短(P<0.05).结论 在婴幼儿气管异物取出术中,采用罗库溴铵联合高频控制通气较保留自主呼吸更能减少术中缺氧等不良反应的发生,缩短手术时间,苏醒更快且平稳. Abstract： Objective To investigate the efficacy of rocuronium combined with high-frequency ventilation for anaesthesia of airway foreign bodies removal in children.Methods Forty-two ASA Ⅰ-Ⅱ children undergoing airway foreign bodies removal were randomly divided into rocuronium group(R)and control group(C),there were 21 cases in each group. In group R,the children were anesthetized with intravenous midazolam,ketamine,rocuronium and high-frequency mechanically ventilated after bronchoscope intubation. In group C, the children were anesthetized with midazolam,ketamine,fentanyl and assistantly ventilated after bronchoscope intubation. ECG, HR,MAP,RR,SpO2 were continuously monitored. Adverse events(hypoxia, bradycardia,cough,airway convulsion), duration of operation, the time of recovery, postoperative complications (nausea,vomiting,agitated,airway convulsion)were recorded.Results The incidence of adverse events during operation and postoperative complications were significantly lower in group R than that in group C. The duration of operation and the time of recovery were significantly shorter in group R than that in group C.Conclusions Rocuronium combined with high-frequency ventilation can reduce adverse events during operation and result in shorter duration of operation,rapid recovery and fewer postoperative complications.