全文获取类型
收费全文 | 582篇 |
免费 | 32篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 32篇 |
口腔科学 | 4篇 |
临床医学 | 22篇 |
内科学 | 33篇 |
皮肤病学 | 4篇 |
神经病学 | 2篇 |
特种医学 | 6篇 |
外科学 | 18篇 |
综合类 | 109篇 |
预防医学 | 102篇 |
眼科学 | 5篇 |
药学 | 155篇 |
中国医学 | 124篇 |
肿瘤学 | 8篇 |
出版年
2024年 | 1篇 |
2023年 | 9篇 |
2022年 | 11篇 |
2021年 | 17篇 |
2020年 | 15篇 |
2019年 | 18篇 |
2018年 | 10篇 |
2017年 | 14篇 |
2016年 | 12篇 |
2015年 | 18篇 |
2014年 | 44篇 |
2013年 | 62篇 |
2012年 | 40篇 |
2011年 | 55篇 |
2010年 | 39篇 |
2009年 | 20篇 |
2008年 | 32篇 |
2007年 | 35篇 |
2006年 | 18篇 |
2005年 | 25篇 |
2004年 | 16篇 |
2003年 | 9篇 |
2002年 | 14篇 |
2001年 | 7篇 |
2000年 | 11篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 8篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 8篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1983年 | 5篇 |
1982年 | 1篇 |
1979年 | 1篇 |
1977年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有630条查询结果,搜索用时 15 毫秒
1.
微乳对难溶性药物增溶机理的研究 总被引:17,自引:1,他引:16
目的:初步探讨微乳对难溶性药物的增溶机理.方法:经处方筛选及相图研究确定(BL-9/正丁醇3∶1)/油/水比例为9∶1∶40的微乳处方;以二氢吡啶类药物为模型药物,测定其在微乳、胶束和油相中的溶解度及油/水分配系数;根据化学结构,采用计算机软件计算药物的特性参数,并结合模型药物的特性分析微乳增溶难溶性药物的机理.结果:微乳对药物的增溶效果远大于油相和胶束,并随药物的脂溶性和空间结构的改变而变化.结论:微乳可用于增溶难溶性药物,且脂溶性越大,空间位阻越小,增溶效果越明显. 相似文献
2.
S. Savi M. Savi S. Tamburi G. Vuleta S. Vesi C.C. Müller-Goymann 《European journal of pharmaceutical sciences》2007,30(5):441-450
There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline phases. The aim of this study was to relate some physicochemical properties (characterised by polarisation and transmission electron microscopy, thermal analysis and rheology) of the three formulations based on cetearyl glucoside and cetearyl alcohol, to the results of in vitro and in vivo bioavailability of hydrocortisone (HC). The three formulations contained oils of different polarity (medium chain triglycerides: MG, isopropyl myristate: IPM and light liquid paraffin: LP), respectively. In vitro permeation was followed through the artificial skin constructs (ASC), while the parameters measured in vivo were erythema index: EI (using instrumental human skin blanching assay), transepidermal water loss (TEWL) and stratum corneum hydration (SCH). The vehicles based on cetearyl glucoside and cetearyl alcohol showed a complex colloidal structure of lamellar liquid-crystalline and lamellar gel-crystalline type, depending on oil polarity. Rheological profile of the vehicle was directly related to the in vitro profile of the HC permeation. In vivo results suggested that the vehicle with MG retarded the HC permeation, whereas less polar IPM and non-polar LP enhanced it. It is suggested that the enhancement is achieved either by a direct interaction with lipid lamellae of the SC or indirectly by improving skin hydration.
There were no adverse effects during in vivo study, which indicates a good safety profile of this alkylpolyglucoside surfactant. 相似文献
3.
Kaisa M. Heiskanen Silvia Münzing Fritz Krombach Kai M. Savolainen 《Archives of toxicology》1997,71(10):627-632
The effects of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of CD11b/CD18, CD11c/CD18 integrins
and l-selectin on human neutrophils were studied by flow cytometry in a whole blood assay. None of these compounds had any effect
on the basal expression of CD11b, CD11c, or l-selectin in the concentration range of 20–100 μM. However, linoleic acid at a concentration of 1000 μM slightly up-regulated
CD11b and CD11c by a factor of 2.1 and 1.7, respectively. Linoleic acid, linoleic acid anilide, and arachidonic acid did not
affect the formyl-methionyl-leucyl-phenylalanine induced up-regulation of CD11b or CD11c. However, linoleic acid and linoleic
acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27
and 21% at concentrations of 100 and 1000 μM, respectively. Likewise, arachidonic acid at 40 μM inhibited the PMA-induced
expression of CD11b by 19%. Our results suggest that linoleic acid, linoleic acid anilide, and arachidonic acid do not dramatically
affect the expression of leukocyte adhesion molecules in a whole blood assay.
Received: 17 February 1997 / Accepted: 5 May 1997 相似文献
4.
目的应用超临界CO2萃取技术提取薏苡仁中的薏苡仁油,优化工艺条件。方法利用1L与600L的超临界萃取装置,考察原料水份、压力、时间与温度等参数对薏苡仁油提取得率的影响。结果优化得到用超临界CO2萃取技术从薏苡仁中提取薏苡仁油的工艺参数。结论超临界CO2萃取技术可用于薏苡仁油的提取,适用于工业化生产。 相似文献
5.
6.
Genetic trace metal disturbances can be at three levels. Trace metals play an important role in the metabolism of genetic macromolecules and the information transfer system. Deficiency or excess of trace metals caused either by dietary or genetic factors will affect the normal functioning of the whole organism. The roles of trace metals in carcinogenesis/mutagenesis and ageing are typical of this category. The second level of genetic trace metal disturbances affect the metabolic pathway of the trace metal itself. Biochemical derangement resulting from genetic defects cause aberrant metabolism of the element and thus disease symptoms. Diseases caused by abnormal metabolism of copper, zinc, iron, and molybdenum are discussed. Trace metal disturbances can also be the result of other genetic diseases. This aspect of genetic trace metal disturbances is least investigated. However, information should be important for improving the existing treatment protocol for the more common inborn errors of metabolism, such as phenylketonuria. 相似文献
7.
8.
AimTo critically appraise and evaluate the evidence from randomized clinical trials (RCTs) examining the effectiveness of oil pulling on oro dental hygiene.MethodsWe conducted electronic searches in Medline, Embase, Amed, The Cochrane Library and Cinahl databases from inception to February 2015, and assessed reporting quality using the Cochrane risk of bias criteria. We included RCTs that compared oil pulling using conventional cooking oils with a control intervention. Our primary outcomes were measures of oro dental hygiene using validated scales.ResultsElectronic searches yielded 26 eligible studies, of which five RCTs comprising a total of 160 participants were included. The studies varied in reporting quality, lasted between 10 and 45 days, and compared oil pulling with chlorhexidine, placebo or routine dental hygiene practice. Three studies reported no significant differences in post intervention plaque index scores between oil pulling and control groups (Chlorhexidine mouthwash +/− Placebo): p = 0.28, 0.94, and 0.38, respectively. Two studies reported no significant difference in post-intervention modified gingival index score between oil pulling and Chlorhexidine mouthwash groups (p = 0.32 and 0.64).ConclusionThe limited evidence to date from clinical trials suggests that oil pulling may have beneficial effects on oro dental hygiene as seen for the short period of time investigated. Given that this is a potentially cost-effective intervention, this practice might be of particular benefit. Future clinical trials should be more rigorous and better reported. 相似文献
9.
目的:揭示大果木姜子油治疗心力衰竭的作用机制。方法:首先从动物药理学实验验证疗效,采用异丙肾上腺素(ISO)诱导复制心力衰竭大鼠模型,造模成功后应用大果木姜子油治疗4周,监测血流动力学指标,分析血清BNP水平和心肌组织形态学变化;然后基于文献检索和TCMSP数据库获取大果木姜子油活性成分及作用靶点,从CTD和Drugbank数据库筛选心力衰竭的已知治疗靶点,将疾病治疗靶点与大果木姜子油活性成分作用靶点进行Venn分析,运用SYBYL软件进行分子对接验证,运用STRING数据库分析蛋白互作关系,再利用DAVID数据库进行GO分子功能和KEGG通路富集分析。结果:大果木姜子油可显著升高ISO诱导的心衰大鼠LVSP、±dp/dtmax,降低LVEDP和BNP水平,改善心肌组织形态学变化;获得大果木姜子油20个活性成分,其中7个活性成分(沉香螺旋醇、芳樟醇、萜品烯-4-醇等)可能通过调控一个蛋白互作网络治疗心力衰竭,该网络中的靶点有PTGS1、PTGS2、NOS2、NOS3、GSK3B;由蛋白富集分析发现,这些靶点与前列腺素内过氧化物合酶活性和一氧化氮合酶活性有关。结论:大果木姜子油可改善心衰大鼠的血流动力学紊乱及心肌组织形态学变化;其治疗心力衰竭的机制可能与调控前列腺素内过氧化物合酶活性和一氧化氮合酶活性有关。 相似文献
10.
目的 建立清热解肌颗粒中挥发油成分的质量标准.方法 采用薄层色谱法(TLC)对清热解肌颗粒中挥发油进行定性鉴别;采用气—质联用色谱仪(GC-MS)对挥发油提取物的成分进行鉴定;采用气相色谱法(GC)测定制剂中挥发油的含量.结果 薄层色谱斑点清晰,重现性好,阴性对照无干扰.GC-MS共检出13个色谱峰并鉴定出12个化合物.α-蒎烯、β-蒎烯、桉油精线性范围分别为1.89~605.00mg·L-1(r=1.000),1.25 ~99.60mg· L-1(r=1.000),2.32 ~185.81 mg·L-1(r=1.000),平均加样回收率分别为92.82%(RSD =4.83%)、94.29%(RSD=3.10%)和104.23% (RSD =3.14%) (n =9).结论 所建立的方法准确、可靠、专属性强,可用于该制剂的质量控制. 相似文献