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排序方式: 共有87条查询结果,搜索用时 15 毫秒
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Yuichi Yamada Teruhiko Kido Masao Ishizaki Ryumon Honda Ikiko Tsuritani Haruki Yamaya Kôji Nogawa 《International archives of occupational and environmental health》1988,60(1):7-14
Summary Forty-nine out of 54 male workers engaged in the production of an epoxy compound, t-methyl-3-phenylglycidate, showed skin symptoms in varing degrees that may be due to the skin-irritative effect of the compound. The exposed workers were also shown to have subjective symptoms which may be related to the irritative property of the compound on surface tissue. Laboratory examinations on the blood obtained from the exposed workers showed significantly higher values of leukocyte concentration as compared with the non-exposed controls. This was chiefly caused by the increase of neutrophilic granulocytes and T-cell lymphocytes. Serum IgA levels of the exposed workers were shown to be significantly lower than those of the control group. Hemoglobin concentration, hematocrit value and red cell count of the exposed workers remained at the same level as those of the control subjects. Liver or kidney damage was not found in biochemical analyses on the sera of exposed workers. 相似文献
3.
Human leukocyte response to an endurance race 总被引:3,自引:0,他引:3
A. Vishnu Moorthy Stephen W. Zimmerman M.D. 《European journal of applied physiology》1978,38(4):271-276
Summary The response of circulating leukocytes (WBC's) with regard to changes in number, proportion of neutrophils versus lymphocytes and changes in lymphocyte function as well as proportions of T and B cells was studied in eleven men who ran a 20-mile race. A marked leukocytosis was noted 10–15 min after the race with the predominant increase being polymorphonuclear leukocytes (P<0.001). A significant rise in mean serum cortisol levels was also noted (P<0.001) which correlated with both the increase in total WBC's (P< 0.001) and granulocytes (P<0.001), but not lymphocytes. The increase in serum cortisol was inversely correlated with miles of prior training (P<0.001). An increase in lymphocytes from 1767±112/mm3 to 2431±202/mm3 was less than that previously described in short-term exercise. As with short-term exercise the most significant increase in lymphocytes was in B lymphocytes bearing surface immunoglobulin (P<0.0025). However, in contrast to short-term exercise lymphocytes maintained good in vitro response to the mitogen phytohemagglutinin.This study demonstrates that endurance racing produces a more marked granulocytosis and less lymphocytosis than short bouts of exercise. It is suggested that the degree of leukocytosis is stress dependent in that it was positively correlated with serum cortisol and inversely correlated with prior training.Supported in part by a joint fellowship from the National and Wisconsin Kidney Foundations 相似文献
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5.
Sang-Wook Shin Woo Kyoung Jeong Sanghyeok Lim Yongsoo Kim Jinoo Kim 《Clinical and molecular hepatology》2015,21(1):71-79
Background/Aims
To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease.Methods
This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2-3 days, and 1-2 weeks after RFA. We classified the subjects into two groups: Child-Pugh A (n=41) and Child-Pugh B (n=24). The ablative margin volume (AMV) of each patient was measured. We analyzed the changes in laboratory profiles from the baseline, and investigated whether these laboratory changes were correlated with the AMV and the Child-Pugh classification.Results
Most of the laboratory values peaked at 2-3 days after RFA. AMV was significantly correlated with changes in WBC count, hemoglobin level, and serum total bilirubin level (Pearson''s correlation coefficient, 0.324-0.453; P<0.05). The alanine aminotransferase (ALT) level varied significantly over time (P=0.023).Conclusions
Most of the measured laboratory markers changed from baseline, peaking at 2-3 days. The ALT level was the only parameter for which there was a significant difference after RFA between Child-Pugh A and B patients: it increased significantly more in the Child-Pugh A patients. 相似文献6.
Kaoru Tohyama Yataro Yoshida Kensaku Ohashi Emiko Sano Hisataka Kobayashi Keigo Endo Masanobu Naruto Toru Nakamura 《Cancer science》1992,83(2):153-158
A multiple growth factor-producing tumor cell line (NIM-1) was newly established from a patient with thyroid cancer and remarkable neutrophilia. NIM-1 cells also caused severe neutrophilia in nude mice bearing tumors. NIM-1-conditioned medium (NIM-1CM) contained activities that supported not only granulocyte, macrophage and eosinophil colony formation of human bone marrow cells but also the growth of colony-stimulating factor (CSF)-dependent cell lines, NFS60-KX and TF-1. Northern blot hybridization analysis revealed the constitutive expression of granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF) and interleukin(IL)-6 mRNAs in NIM-1 cells. Enzyme-linked immunosorbent assays (ELISA) using NIM-1CM also confirmed the production of IL-la and a small amount of IL-1β besides G-CSF, GM-CSF and IL-6 in NIM-1 cells. In addition, unexpected production of IL-11 in NIM-1 cells was detected by northern blot hybridization analysis and by bioassay using an IL-11-dependent cell line. Therefore, NIM-1 cell line is shown to produce multiple cytokines including potentially megakaryopoietic growth factors such as GM-CSF, IL-6 and IL-11. 相似文献
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8.
Despite a clear role for leukocytes in modulating the pathophysiology of sickle cell disease (SCD), the mechanism by which
leukocyte numbers are increased in this disorder remains unclear. Hypothesizing that the chronic inflammatory state, elicited
by adhesive interactions involving various cell types, might underlie leukocytosis, we measured plasma levels of proinflammatory
or myeloid cytokines that play a role in leukocytosis and examined their correlations with leukocyte numbers in patients with
SCD. Our studies found that, although plasma levels of granulocyte–macrophage colony-stimulating factor (GM-CSF), interleukin
3, and macrophage colony-stimulating factor are elevated in steady-state patients with SCD, only plasma GM-CSF levels are
positively correlated with the numbers of total leukocytes, neutrophils, monocytes, and eosinophils, regardless of whether
they received hydroxyurea. GM-CSF levels were significantly decreased in patients on hydroxyurea therapy. These data suggest
a role of GM-CSF in leukocytosis of SCD. In contrast, plasma levels of granulocyte colony-stimulating factor, a major cytokine
that induces leukocytosis due to bacterial infection, were lower than those of control subjects. These results indicate that
elevated GM-CSF levels may contribute, at least in part, to high leukocyte numbers in SCD. As plasma GM-CSF levels were decreased
in patients on hydroxyurea therapy, hydroxyurea may decrease leukocyte numbers by reducing circulating GM-CSF levels.
Electronic supplementary material Supplementary material is available in the online version of this article at and is accessible for authorized users. 相似文献
9.
目的探讨高白细胞性急性白血病的临床特征及免疫表型特点。方法采用流式细胞术对48例高白细胞性白血病(HLAL)和189例非高白细胞性白血病(NHLA)患者进行免疫表型检测,并对结果及临床特征进行分析。结果 HLAL与NHLAL比较,患者起病急,进展快,完全缓解(CR)率低(P<0.05),髓外浸润明显,骨髓增生活跃(P<0.05)。高白细胞性急性淋巴细胞白血病(HLALL)可以同时表达不同系列的抗原。HLALL、高白细胞性急性髓系白血病(HLAML)、非高白细胞性急性淋巴细胞白血病(NHLALL)与非高白细胞性急性髓系白血病(NHLAML)4组CD7抗原表达比较差异无统计学意义(P>0.05)。HLAML和NHLAML,髓系抗原表达阳性率较高的均为CD33和CD13。结论 HLAL与NHLAL相比进展较快,骨髓增生更为活跃,预后不良。急性淋巴细胞白血病(ALL)的白血病细胞异质性更高,尤其是HLALL。CD7系列特异性不明显,CD33和CD13作为髓系的特异性抗原较为可靠。 相似文献
10.
Takashi Irioka Ayaka Yamanami Yohsuke Yagi Hidehiro Mizusawa 《Neurological sciences》2009,30(3):255-258
A 55-year-old man suddenly developed anterograde and retrograde amnesia. His colleagues witnessed the onset of the episode
and reported that 2 h before the onset of the amnesic attack the patient transiently became pale. Physical examination was
unremarkable and neurological examination revealed no focal neurological sign although a laboratory investigation revealed
leukocytosis. Pure transient global amnesia (TGA) was diagnosed. The anterograde amnesia resolved 20 h after onset, but the
causes of his transient paleness precedent to TGA and leukocytosis were unclear. Thirty-four hours after onset, the patient
complained of sudden back pain and radiological studies revealed aortic dissection (AD; Stanford type B). We emphasize AD
as a rare cause of pure TGA, because TGA in itself often has a benign natural history, but AD can be life-threatening if undiagnosed.
The precedent pain, transient systemic symptoms, and leukocytosis can be red flags suggesting AD as an etiology of TGA. 相似文献